Nuclear organization

Nuclear organization refers to the spatial distribution of nuclear contents and components in a way that reflects or facilitates their activities. For example, chromatin or nucleoli may become more condensed or expanded in response to changes in gene expression or cellular growth rate.

Latest Research and Reviews

  • Research
    | Open Access

    Mandibuloacral dysplasias (MADs) are rare progeroid syndromes characterized by nuclear morphological and functional abnormalities. Here the authors report that loss of mitochondrial membrane protein MTX2 causes a progeroid MAD sharing clinical features with lamin-associated progeroid syndromes.

    • Sahar Elouej
    • , Karim Harhouri
    • , Morgane Le Mao
    • , Genevieve Baujat
    • , Sheela Nampoothiri
    • , Hϋlya Kayserili
    • , Nihal Al Menabawy
    • , Laila Selim
    • , Arianne Llamos Paneque
    • , Christian Kubisch
    • , Davor Lessel
    • , Robert Rubinsztajn
    • , Chayki Charar
    • , Catherine Bartoli
    • , Coraline Airault
    • , Jean-François Deleuze
    • , Agnes Rötig
    • , Peter Bauer
    • , Catarina Pereira
    • , Abigail Loh
    • , Nathalie Escande-Beillard
    • , Antoine Muchir
    • , Lisa Martino
    • , Yosef Gruenbaum
    • , Song-Hua Lee
    • , Philippe Manivet
    • , Guy Lenaers
    • , Bruno Reversade
    • , Nicolas Lévy
    •  & Annachiara De Sandre-Giovannoli
  • Research
    | Open Access

    mRNAs export from the nucleus is thought to be regulated in part by three nucleoporins that comprise the nuclear basket, but whether and how distinct basket nucleoporins interact with the RNA export machinery is unclear. Here, the authors use rapid auxin-mediated degradation of basket nucleoporins Nup153, Nup50, and Tpr, and see that Tpr interacts with the TREX-2 mRNA export complex.

    • Vasilisa Aksenova
    • , Alexandra Smith
    • , Hangnoh Lee
    • , Prasanna Bhat
    • , Caroline Esnault
    • , Shane Chen
    • , James Iben
    • , Ross Kaufhold
    • , Ka Chun Yau
    • , Carlos Echeverria
    • , Beatriz Fontoura
    • , Alexei Arnaoutov
    •  & Mary Dasso
  • Research |

    The surfactant-like protein Ki-67 mediates the clustering of chromosomes during mitotic exit, which displaces large cytoplasmic molecules from the future nuclear space and thus enables the separation of cytoplasmic and nuclear components before the nuclear envelope reforms.

    • Sara Cuylen-Haering
    • , Mina Petrovic
    • , Alberto Hernandez-Armendariz
    • , Maximilian W. G. Schneider
    • , Matthias Samwer
    • , Claudia Blaukopf
    • , Liam J. Holt
    •  & Daniel W. Gerlich
    Nature, 1-6

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