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Letter |
The pluripotent genome in three dimensions is shaped around pluripotency factors
Using 4C technology, higher-order topological features of the pluripotent genome are identified; in pluripotent stem cells, Nanog clusters specifically with other pluripotency genes and this clustering is centred around Nanog-binding sites, suggesting that Nanog helps to shape the three-dimensional structure of the pluripotent genome and thereby contributes to the robustness of the pluripotent state.
- Elzo de Wit
- , Britta A. M. Bouwman
- & Wouter de Laat
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Letter |
Determinants of nucleosome organization in primary human cells
- Anton Valouev
- , Steven M. Johnson
- & Arend Sidow
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Research Highlights |
Genomics: DNA packaging unravelled
Chromatin connectivity maps reveal dynamic promoter–enhancer long-range associations
The pluripotent genome in three dimensions is shaped around pluripotency factors
Determinants of nucleosome organization in primary human cells