Neurotransmitters articles from across Nature Portfolio

Serotonin is involved in aversive processing, but how serotonin shapes behavior remains unclear. Here, the authors show that directly enhancing synaptic serotonin in humans reduces outcome sensitivity and increases behavioral inhibition in aversive contexts.

Dong et al. developed and validated κLight, δLight and µLight, a suite of genetically encoded opioid peptide sensors for probing opioid drugs and brain-region/circuit-specific opioid release in behaving animals.

Cerebellar nuclei (CN) neurons receive synapses from Purkinje cells, yet how these are spatially organized has been unknown. Here, authors show inputs are clustered along transverse zones with many CN cells receiving multi-zonal input, suggesting multimodal integration occurs in the CN.

The G-protein-coupled receptor GPR158 acts as a metabotropic glycine receptor in mice.

Seung-Hee Lee describes findings published in 2000 that gave us insight into the principles by which different types of GABAergic synapses are organized in cortical networks.

Until now, the BDNF–TrkB signalling pathway was thought to be exclusively regulated by neurons. Ameroso et al. show that astrocytic TrkB.T1 is a critical substrate of BDNF in the regulation of energy balance and that its defective signalling in hypothalamic circuits leads to obesity.

Schneider et al. show that peripheral serotonin augments colorectal and pancreatic tumour growth in mice by increasing PDL1 expression on cancer cells, and in turn inhibiting the accumulation of functional CD8⁺ T cells within tumours.