Neurotransmitters articles from across Nature Portfolio

The relationship between striatal vascular and neural activity is not fully understood. Here the authors found neuronal activity inadequately explains striatal hemodynamic polarity, challenging classic fMRI interpretations.

LAR-RPTPs are presynaptic cell-adhesion proteins that regulate the synaptic properties. Here, LAR-RPTP microexon expression is profiled in region-, cell-type- and circuit-specific contexts and its physiological significance in encoding synaptic architecture is demonstrated.

Mohebi et al. report that dopamine (DA) pulses in different rat striatal subregions signal prediction errors across different timescales. In this way, one learning process may achieve a range of adaptive behaviors.

Compartments of neurons can sometimes act as independent computational units. Here the authors show that retinal bipolar cells, some of the smallest mammalian neurons, send different signals to downstream ganglion cells via different synapses.

The G-protein-coupled receptor GPR158 acts as a metabotropic glycine receptor in mice.

Seung-Hee Lee describes findings published in 2000 that gave us insight into the principles by which different types of GABAergic synapses are organized in cortical networks.

Until now, the BDNF–TrkB signalling pathway was thought to be exclusively regulated by neurons. Ameroso et al. show that astrocytic TrkB.T1 is a critical substrate of BDNF in the regulation of energy balance and that its defective signalling in hypothalamic circuits leads to obesity.

Schneider et al. show that peripheral serotonin augments colorectal and pancreatic tumour growth in mice by increasing PDL1 expression on cancer cells, and in turn inhibiting the accumulation of functional CD8⁺ T cells within tumours.