Neuroscience

Definition

Neuroscience is a multidisciplinary science that is concerned with the study of the structure and function of the nervous system. It encompasses the evolution, development, cellular and molecular biology, physiology, anatomy and pharmacology of the nervous system, as well as computational, behavioural and cognitive neuroscience.

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Latest Research and Reviews

  • Reviews |

    Recent studies that combine cell biology, structural and proteomic approaches have unravelled how ubiquitin is conjugated to damaged mitochondria through the PINK1–parkin pathway to promote mitophagy. The findings have revealed links between PINK1–parkin, antigen presentation and neuronal survival and have implications for the understanding of neurological disorders.

    • J. Wade Harper
    • , Alban Ordureau
    •  & Jin-Mi Heo
  • Research |

    The authors show that inhibitory interneurons in cortical layer 1 integrate topographically organized thalamic and neuromodulatory inputs to sculpt sound frequency maps in primary auditory cortex during a developmental critical period.

    • Anne E. Takesian
    • , Luke J. Bogart
    • , Jeff W. Lichtman
    •  & Takao K. Hensch
  • Research |

    Analysis of Pax7 dynamics during pituitary lineage specification shows that Pax7 binds rapidly at uniquely marked heterochromatin pioneer sites and initiates chromatin opening that remains stable after Pax7 withdrawal, with loss of DNA hypermethylation at pioneered enhancers.

    • Alexandre Mayran
    • , Konstantin Khetchoumian
    • , Fadi Hariri
    • , Tomi Pastinen
    • , Yves Gauthier
    • , Aurelio Balsalobre
    •  & Jacques Drouin
  • Research | | open

    Abnormal cytoplasmic aggregates of FUS are a hallmark of some forms of amyotrophic lateral sclerosis (ALS). Here, using neurons derived from patients with FUS-ALS, the authors demonstrate that impairment of PARP-dependent DNA damage signaling is an event that occurs upstream of neurodegeneration and cytoplasmic aggregate formation in FUS-ALS.

    • Marcel Naumann
    • , Arun Pal
    • , Anand Goswami
    • , Xenia Lojewski
    • , Julia Japtok
    • , Anne Vehlow
    • , Maximilian Naujock
    • , René Günther
    • , Mengmeng Jin
    • , Nancy Stanslowsky
    • , Peter Reinhardt
    • , Jared Sterneckert
    • , Marie Frickenhaus
    • , Francisco Pan-Montojo
    • , Erik Storkebaum
    • , Ina Poser
    • , Axel Freischmidt
    • , Jochen H. Weishaupt
    • , Karlheinz Holzmann
    • , Dirk Troost
    • , Albert C. Ludolph
    • , Tobias M. Boeckers
    • , Stefan Liebau
    • , Susanne Petri
    • , Nils Cordes
    • , Anthony A. Hyman
    • , Florian Wegner
    • , Stephan W. Grill
    • , Joachim Weis
    • , Alexander Storch
    •  & Andreas Hermann
  • Research | | open

    Reciprocal connectivity enables tightly coupled information processing across cortical areas. Here the authors develop a visual oculomotor task in mice, identify a small motor area required for it, and demonstrate selective exchange of sensory and motor information between the motor and sensory areas.

    • Takahide Itokazu
    • , Masashi Hasegawa
    • , Rui Kimura
    • , Hironobu Osaki
    • , Urban-Raphael Albrecht
    • , Kazuhiro Sohya
    • , Shubhodeep Chakrabarti
    • , Hideaki Itoh
    • , Tetsufumi Ito
    • , Tatsuo K. Sato
    •  & Takashi R. Sato

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