Neuroscience articles within Nature Reviews Cardiology

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  • Research Highlight |

    The cardiac parasympathetic nervous system is composed of two parallel circuits with distinct functions: one selectively controls cardiac function and another coordinates cardiac and pulmonary function.

    • Irene Fernández-Ruiz

  • Comment |

    Retinal microvascular changes are strongly linked to prevalent and incident cardiovascular disease. These changes can now be mapped with unparalleled accuracy using retinal optical coherence tomography. Novel retinal imaging, combined with the power of deep learning, might soon equip clinicians with unique and precise risk-assessment tools that enable truly individualized patient management.

    • Tariq E. Farrah
    • , David J. Webb
    •  & Neeraj Dhaun

  • Review Article |

    In this Review, Kivimäki and Steptoe assess the current evidence on the association between stress and cardiovascular disease, covering the multiple roles of stress in the development and triggering of disease and as a determinant of prognosis and outcome. In addition, they discuss the clinical and public health importance of major stressors and the implications for prevention and treatment of cardiovascular disease.

    • Mika Kivimäki
    •  & Andrew Steptoe

  • Review Article |

    Abnormalities in the control of intracellular calcium are involved in several forms of inherited arrhythmias. The genetic mutations that cause these abnormalities have generated much research interest in the past decade. Here, Venetucci et al. provide an overview of the structural organization and the function of calcium-handling proteins and describe the mechanisms by which mutations determine the various clinical phenotypes of calcium channelopathies.

    • Luigi Venetucci
    • , Marco Denegri
    •  & Silvia G. Priori

  • Review Article |

    Psychological stress is thought to contribute to the cardiovascular disease process at several stages, including the long-term development of coronary heart disease and acute triggering of cardiac events. In this Review, Steptoe and Kivimäki summarize the evidence for the association between stress and cardiovascular disease, with a focus on external work-related and social stressors. They also discuss the effects of stress-management strategies on cardiovascular health.

    • Andrew Steptoe
    •  & Mika Kivimäki

  • Review Article |

    Both hypertension and hypotension have been associated with late-life cognitive decline and dementia. Novak and Hajjar discuss evidence supporting the relationship between blood pressure and cognition and its underlying pathophysiological mechanisms. The role that antihypertensive therapy may have in the prevention of cognitive decline is also explored.

    • Vera Novak
    •  & Ihab Hajjar

  • News & Views |

    Anxiety has been shown to have prognostic importance in the development of coronary heart disease in initially healthy adults. This finding highlights the need of future research that includes representative samples of women and minorities, and uses precise assessment tools and careful ascertainment of clinical end points.

    • James A. Blumenthal
    •  & Patrick J. Smith

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