Neuroscience

  • Article
    | Open Access

    Tau plays an important role in tauopathies and undergoes liquid-liquid phase separation (LLPS). The authors show that disease-related P301L mutant and phosphomimic (S199E/S202E/T205E) tau enhance LLPS in vitro at physiological levels, and using specific antibodies, that tau LLPS leads to pathological conformations such as N-terminal exposure and oligomeric species.

    • Nicholas M. Kanaan
    • , Chelsey Hamel
    • , Tessa Grabinski
    •  & Benjamin Combs
  • Article
    | Open Access

    The orbitofrontal cortex (OFC) encodes expected outcomes and plays a key role in outcome-guided behavior. The authors show here that the top-down projection from the OFC to the visual cortex drives visual associative learning by modulating the response gain of V1 neurons to non-relevant stimuli.

    • Dechen Liu
    • , Juan Deng
    • , Zhewei Zhang
    • , Zhi-Yu Zhang
    • , Yan-Gang Sun
    • , Tianming Yang
    •  & Haishan Yao
  • Article
    | Open Access

    Small molecule polyamines participate in diverse aspects of cell growth and differentiation and are known to regulate ion channel gating. Here authors reveal that cellular polyamines control nicotinic acetylcholine receptor (nAChR) biogenesis, and either catabolic degradation or inhibition of polyamine production augments nAChR assembly.

    • Madhurima Dhara
    • , Jose A. Matta
    • , Min Lei
    • , Daniel Knowland
    • , Hong Yu
    • , Shenyan Gu
    •  & David S. Bredt
  • Article
    | Open Access

    Music varies across cultures, but some features are widespread, consistent with biological constraints. Here, the authors report that both Western and native Amazonian listeners perceptually fuse concurrent notes related by simple-integer ratios, suggestive of one such biological constraint.

    • Malinda J. McPherson
    • , Sophia E. Dolan
    • , Alex Durango
    • , Tomas Ossandon
    • , Joaquín Valdés
    • , Eduardo A. Undurraga
    • , Nori Jacoby
    • , Ricardo A. Godoy
    •  & Josh H. McDermott
  • Article
    | Open Access

    Here, the authors show that rats’ performance on olfactory decision tasks is best explained by a Bayesian model that combines reinforcement-based learning with accumulation of uncertain sensory evidence. The results suggest that learning is a critical factor contributing to speed-accuracy tradeoffs.

    • André G. Mendonça
    • , Jan Drugowitsch
    • , M. Inês Vicente
    • , Eric E. J. DeWitt
    • , Alexandre Pouget
    •  & Zachary F. Mainen
  • Article
    | Open Access

    Dorsal raphe 5HT(DRSert) neurons regulate arousal from hypercapnia by their projections to the neurons in the external lateral parabrachial nucleus (PBel) that are glutamatergic and also express calcitonin gene related peptide (PBelCGRP). The DRSert input to the PBel modulates the arousal system to rising levels of blood CO2, and may be mediated by 5HT2a receptors on the PBelCGRP neurons.

    • Satvinder Kaur
    • , Roberto De Luca
    • , Mudasir A. Khanday
    • , Sathyajit S. Bandaru
    • , Renner C. Thomas
    • , Rebecca Y. Broadhurst
    • , Anne Venner
    • , William D. Todd
    • , Patrick M. Fuller
    • , Elda Arrigoni
    •  & Clifford B. Saper
  • Article
    | Open Access

    Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce elevated levels of activity in Fmr1 KO mice.

    • Xiaoqin Zhan
    • , Hadhimulya Asmara
    • , Ning Cheng
    • , Giriraj Sahu
    • , Eduardo Sanchez
    • , Fang-Xiong Zhang
    • , Gerald W. Zamponi
    • , Jong M. Rho
    •  & Ray W. Turner
  • Article
    | Open Access

    Brain disorders can create maladaptive attractions, such as in addiction or self-harming. Here the authors use multiple valence modes of the central amygdala to create such attractions, arbitrarily making rats into ‘sucrose addicts' or ‘cocaine addicts', or causing maladaptive attraction to shocks.

    • Shelley M. Warlow
    • , Erin E. Naffziger
    •  & Kent C. Berridge
  • Article
    | Open Access

    Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Here, the authors show that microglia-specific deletion of TSPO and chemical inhibition of TSPO prevent neuroinflammation and vascular damage in a mouse model of AMD.

    • Anne Wolf
    • , Marc Herb
    • , Michael Schramm
    •  & Thomas Langmann
  • Article
    | Open Access

    α-Syn in CSF is a biomarker of neurodegenerative diseases; however, the detection of clinically relevant species is difficult. Here, the authors create a nanobody biosensor that reveals the presence of α-Syn in cells, which allow the detection of transmittable forms of α-Syn present in human CSF.

    • Christoph Gerdes
    • , Natalia Waal
    • , Thomas Offner
    • , Eugenio F. Fornasiero
    • , Nora Wender
    • , Hannes Verbarg
    • , Ivan Manzini
    • , Claudia Trenkwalder
    • , Brit Mollenhauer
    • , Timo Strohäker
    • , Markus Zweckstetter
    • , Stefan Becker
    • , Silvio O. Rizzoli
    • , Fitnat Buket Basmanav
    •  & Felipe Opazo
  • Article
    | Open Access

    Mutations in the TRPV4 channel cause inherited neurodegeneration syndromes, but the molecular mechanisms are unknown. Here the authors reveal that TRPV4 activation causes dose-dependent, CaMKII-mediated neuronal dysfunction and axonal degeneration via disruption of mitochondrial axonal transport.

    • Brian M. Woolums
    • , Brett A. McCray
    • , Hyun Sung
    • , Masashi Tabuchi
    • , Jeremy M. Sullivan
    • , Kendra Takle Ruppell
    • , Yunpeng Yang
    • , Catherine Mamah
    • , William H. Aisenberg
    • , Pamela C. Saavedra-Rivera
    • , Bryan S. Larin
    • , Alexander R. Lau
    • , Douglas N. Robinson
    • , Yang Xiang
    • , Mark N. Wu
    • , Charlotte J. Sumner
    •  & Thomas E. Lloyd
  • Article
    | Open Access

    The netrin receptor UNC-40/DCC is required to recruit GABAAR at neuromuscular junctions in C. elegans. Here, the authors show that UNC-40/DCC assembles an intracellular synaptic scaffold, regulating the content of GABAAR and inhibitory neurotransmission.

    • Xin Zhou
    • , Marine Gueydan
    • , Maelle Jospin
    • , Tingting Ji
    • , Aurore Valfort
    • , Bérangère Pinan-Lucarré
    •  & Jean-Louis Bessereau
  • Article
    | Open Access

    Sensory hypersensitivity is common in autism spectrum disorders. Using functional MRI, psychophysics, and computational modeling, Schallmo et al. show that differences in visual motion perception in ASD are accompanied by weaker neural suppression in visual cortex.

    • Michael-Paul Schallmo
    • , Tamar Kolodny
    • , Alexander M. Kale
    • , Rachel Millin
    • , Anastasia V. Flevaris
    • , Richard A. E. Edden
    • , Jennifer Gerdts
    • , Raphael A. Bernier
    •  & Scott O. Murray
  • Article
    | Open Access

    Although the feeling of being stressed is ubiquitous and clinically significant, the underlying neural mechanisms are unclear. Using a novel predictive modeling approach, the authors show that functional hippocampal networks specifically and consistently predict the feeling of stress.

    • Elizabeth V. Goldfarb
    • , Monica D. Rosenberg
    • , Dongju Seo
    • , R. Todd Constable
    •  & Rajita Sinha
  • Article
    | Open Access

    Path integration abilities, important for spatial navigation, vary widely across individuals and deteriorate in old age. This work shows that path integration errors in general, as well as age-related path integration deficits, are mainly caused by accumulating noise in people’s velocity estimation.

    • Matthias Stangl
    • , Ingmar Kanitscheider
    • , Martin Riemer
    • , Ila Fiete
    •  & Thomas Wolbers
  • Article
    | Open Access

    The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

    • Jacob W. Vogel
    • , Yasser Iturria-Medina
    • , Olof T. Strandberg
    • , Ruben Smith
    • , Elizabeth Levitis
    • , Alan C. Evans
    • , Oskar Hansson
    • , Michael Weiner
    • , Paul Aisen
    • , Ronald Petersen
    • , Clifford R. Jack Jr.
    • , William Jagust
    • , John Q. Trojanowki
    • , Arthur W. Toga
    • , Laurel Beckett
    • , Robert C. Green
    • , Andrew J. Saykin
    • , John Morris
    • , Leslie M. Shaw
    • , Enchi Liu
    • , Tom Montine
    • , Ronald G. Thomas
    • , Michael Donohue
    • , Sarah Walter
    • , Devon Gessert
    • , Tamie Sather
    • , Gus Jiminez
    • , Danielle Harvey
    • , Michael Donohue
    • , Matthew Bernstein
    • , Nick Fox
    • , Paul Thompson
    • , Norbert Schuff
    • , Charles DeCArli
    • , Bret Borowski
    • , Jeff Gunter
    • , Matt Senjem
    • , Prashanthi Vemuri
    • , David Jones
    • , Kejal Kantarci
    • , Chad Ward
    • , Robert A. Koeppe
    • , Norm Foster
    • , Eric M. Reiman
    • , Kewei Chen
    • , Chet Mathis
    • , Susan Landau
    • , Nigel J. Cairns
    • , Erin Householder
    • , Lisa Taylor Reinwald
    • , Virginia Lee
    • , Magdalena Korecka
    • , Michal Figurski
    • , Karen Crawford
    • , Scott Neu
    • , Tatiana M. Foroud
    • , Steven Potkin
    • , Li Shen
    • , Faber Kelley
    • , Sungeun Kim
    • , Kwangsik Nho
    • , Zaven Kachaturian
    • , Richard Frank
    • , Peter J. Snyder
    • , Susan Molchan
    • , Jeffrey Kaye
    • , Joseph Quinn
    • , Betty Lind
    • , Raina Carter
    • , Sara Dolen
    • , Lon S. Schneider
    • , Sonia Pawluczyk
    • , Mauricio Beccera
    • , Liberty Teodoro
    • , Bryan M. Spann
    • , James Brewer
    • , Helen Vanderswag
    • , Adam Fleisher
    • , Judith L. Heidebrink
    • , Joanne L. Lord
    • , Ronald Petersen
    • , Sara S. Mason
    • , Colleen S. Albers
    • , David Knopman
    • , Kris Johnson
    • , Rachelle S. Doody
    • , Javier Villanueva Meyer
    • , Munir Chowdhury
    • , Susan Rountree
    • , Mimi Dang
    • , Yaakov Stern
    • , Lawrence S. Honig
    • , Karen L. Bell
    • , Beau Ances
    • , John C. Morris
    • , Maria Carroll
    • , Sue Leon
    • , Erin Householder
    • , Mark A. Mintun
    • , Stacy Schneider
    • , Angela OliverNG
    • , Randall Griffith
    • , David Clark
    • , David Geldmacher
    • , John Brockington
    • , Erik Roberson
    • , Hillel Grossman
    • , Effie Mitsis
    • , Leyla de Toledo-Morrell
    • , Raj C. Shah
    • , Ranjan Duara
    • , Daniel Varon
    • , Maria T. Greig
    • , Peggy Roberts
    • , Marilyn Albert
    • , Chiadi Onyike
    • , Daniel D’Agostino II
    • , Stephanie Kielb
    • , James E. Galvin
    • , Dana M. Pogorelec
    • , Brittany Cerbone
    • , Christina A. Michel
    • , Henry Rusinek
    • , Mony J. de Leon
    • , Lidia Glodzik
    • , Susan De Santi
    • , P. Murali Doraiswamy
    • , Jeffrey R. Petrella
    • , Terence Z. Wong
    • , Steven E. Arnold
    • , Jason H. Karlawish
    • , David Wolk
    • , Charles D. Smith
    • , Greg Jicha
    • , Peter Hardy
    • , Partha Sinha
    • , Elizabeth Oates
    • , Gary Conrad
    • , Oscar L. Lopez
    • , MaryAnn Oakley
    • , Donna M. Simpson
    • , Anton P. Porsteinsson
    • , Bonnie S. Goldstein
    • , Kim Martin
    • , Kelly M. Makino
    • , M. Saleem Ismail
    • , Connie Brand
    • , Ruth A. Mulnard
    • , Gaby Thai
    • , Catherine Mc Adams Ortiz
    • , Kyle Womack
    • , Dana Mathews
    • , Mary Quiceno
    • , Ramon Diaz Arrastia
    • , Richard King
    • , Myron Weiner
    • , Kristen Martin Cook
    • , Michael DeVous
    • , Allan I. Levey
    • , James J. Lah
    • , Janet S. Cellar
    • , Jeffrey M. Burns
    • , Heather S. Anderson
    • , Russell H. Swerdlow
    • , Liana Apostolova
    • , Kathleen Tingus
    • , Ellen Woo
    • , Daniel H. S. Silverman
    • , Po H. Lu
    • , George Bartzokis
    • , Neill R. Graff Radford
    • , Francine Parfitt
    • , Tracy Kendall
    • , Heather Johnson
    • , Martin R. Farlow
    • , Ann Marie Hake
    • , Brandy R. Matthews
    • , Scott Herring
    • , Cynthia Hunt
    • , Christopher H. van Dyck
    • , Richard E. Carson
    • , Martha G. MacAvoy
    • , Howard Chertkow
    • , Howard Bergman
    • , Chris Hosein
    • , Sandra Black
    • , Bojana Stefanovic
    • , Curtis Caldwell
    • , Ging Yuek Robin Hsiung
    • , Howard Feldman
    • , Benita Mudge
    • , Michele Assaly Past
    • , Andrew Kertesz
    • , John Rogers
    • , Dick Trost
    • , Charles Bernick
    • , Donna Munic
    • , Diana Kerwin
    • , Marek Marsel Mesulam
    • , Kristine Lipowski
    • , Chuang Kuo Wu
    • , Nancy Johnson
    • , Carl Sadowsky
    • , Walter Martinez
    • , Teresa Villena
    • , Raymond Scott Turner
    • , Kathleen Johnson
    • , Brigid Reynolds
    • , Reisa A. Sperling
    • , Keith A. Johnson
    • , Gad Marshall
    • , Meghan Frey
    • , Jerome Yesavage
    • , Joy L. Taylor
    • , Barton Lane
    • , Allyson Rosen
    • , Jared Tinklenberg
    • , Marwan N. Sabbagh
    • , Christine M. Belden
    • , Sandra A. Jacobson
    • , Sherye A. Sirrel
    • , Neil Kowall
    • , Ronald Killiany
    • , Andrew E. Budson
    • , Alexander Norbash
    • , Patricia Lynn Johnson
    • , Thomas O. Obisesan
    • , Saba Wolday
    • , Joanne Allard
    • , Alan Lerner
    • , Paula Ogrocki
    • , Leon Hudson
    • , Evan Fletcher
    • , Owen Carmichael
    • , John Olichney
    • , Charles DeCarli
    • , Smita Kittur
    • , Michael Borrie
    • , T. Y. Lee
    • , Rob Bartha
    • , Sterling Johnson
    • , Sanjay Asthana
    • , Cynthia M. Carlsson
    • , Steven G. Potkin
    • , Adrian Preda
    • , Dana Nguyen
    • , Pierre Tariot
    • , Adam Fleisher
    • , Stephanie Reeder
    • , Vernice Bates
    • , Horacio Capote
    • , Michelle Rainka
    • , Douglas W. Scharre
    • , Maria Kataki
    • , Anahita Adeli
    • , Earl A. Zimmerman
    • , Dzintra Celmins
    • , Alice D. Brown
    • , Godfrey D. Pearlson
    • , Karen Blank
    • , Karen Anderson
    • , Robert B. Santulli
    • , Tamar J. Kitzmiller
    • , Eben S. Schwartz
    • , Kaycee M. SinkS
    • , Jeff D. Williamson
    • , Pradeep Garg
    • , Franklin Watkins
    • , Brian R. Ott
    • , Henry Querfurth
    • , Geoffrey Tremont
    • , Stephen Salloway
    • , Paul Malloy
    • , Stephen Correia
    • , Howard J. Rosen
    • , Bruce L. Miller
    • , Jacobo Mintzer
    • , Kenneth Spicer
    • , David Bachman
    • , Elizabether Finger
    • , Stephen Pasternak
    • , Irina Rachinsky
    • , John Rogers
    • , Andrew Kertesz
    • , Dick Drost
    • , Nunzio Pomara
    • , Raymundo Hernando
    • , Antero Sarrael
    • , Susan K. Schultz
    • , Laura L. Boles Ponto
    • , Hyungsub Shim
    • , Karen Elizabeth Smith
    • , Norman Relkin
    • , Gloria Chaing
    • , Lisa Raudin
    • , Amanda Smith
    • , Kristin Fargher
    • , Balebail Ashok Raj
    • , Emelie Andersson
    • , David Berron
    • , Elin Byman
    • , Tone Sundberg-Brorsson
    • , Administrator
    • , Emma Borland
    • , Anna Callmer
    • , Cecilia Dahl
    • , Eske Gertje
    • , Anna-Märta Gustavsson
    • , Joanna Grzegorska
    • , Sara Hall
    • , Oskar Hansson
    • , Philip Insel
    • , Shorena Janelidze
    • , Maurits Johansson
    • , Helena Sletten
    • , Jonas Jester-Broms
    • , Elisabet Londos
    • , Niklas Mattson
    • , Lennart Minthon
    • , Maria Nilsson
    • , Rosita Nordkvist
    • , Katarina Nägga
    • , Camilla Orbjörn
    • , Rik Ossenkoppele
    • , Sebastian Palmqvist
    • , Marie Persson
    • , Alexander Santillo
    • , Nicola Spotorno
    • , Erik Stomrud
    • , Håkan Toresson
    • , Olof Strandberg
    • , Michael Schöll
    • , Ida Friberg
    • , Per Johansson
    • , Moa Wibom
    • , Katarina Johansson
    • , Emma Pettersson
    • , Christin Karremo
    • , Ruben Smith
    • , Yulia Surova
    • , Mattis Jalakas
    • , Jimmy Lätt
    • , Peter Mannfolk
    • , Markus Nilsson
    • , Freddy Ståhlberg
    • , Pia Sundgren
    • , Danielle van Westen
    • , Ulf Andreasson
    • , Kaj Blennow
    • , Henrik Zetterberg
    • , Lars-Olof Wahlund
    • , Eric Westman
    • , Joana Pereira
    • , Jonas Jögi
    • , Douglas Hägerström
    • , Tomas Olsson
    •  & Per Wollmer
  • Article
    | Open Access

    People often ignore evidence that disconfirms their prior beliefs. Here, the authors investigate the underlying cognitive, computational and neuronal mechanisms of such confirmation bias, and show that high confidence induces a selective neural processing of choice-consistent information.

    • Max Rollwage
    • , Alisa Loosen
    • , Tobias U. Hauser
    • , Rani Moran
    • , Raymond J. Dolan
    •  & Stephen M. Fleming
  • Article
    | Open Access

    Alcohol is the leading cause of preventable birth defects in the US, collectively referred to as Fetal Alcohol Spectrum Disorder. Here, the authors show that fetal alcohol exposure induces lasting neurophysiological changes in dorsal striatum that contribute to less efficient decision making.

    • Verginia C. Cuzon Carlson
    • , Christina M. Gremel
    •  & David M. Lovinger
  • Article
    | Open Access

    Semantic dementia patients present with a core semantic impairment and variations of language, behavioural and face recognition abilities. Here, the authors build a unified multidimensional model to capture all these graded symptoms and map them to the variations in the patients’ frontotemporal atrophy.

    • Junhua Ding
    • , Keliang Chen
    • , Haoming Liu
    • , Lin Huang
    • , Yan Chen
    • , Yingru Lv
    • , Qing Yang
    • , Qihao Guo
    • , Zaizhu Han
    •  & Matthew. A. Lambon Ralph
  • Article
    | Open Access

    The mechanisms by which mutant Huntington protein Htt leads to selective neurodegeneration are not fully understood. Here, using gene editing in HD140Q knock-in mice, the authors show that exon1 Htt is a critical pathological form of the protein.

    • Huiming Yang
    • , Su Yang
    • , Liang Jing
    • , Luoxiu Huang
    • , Luxiao Chen
    • , Xianxian Zhao
    • , Weili Yang
    • , Yongcheng Pan
    • , Peng Yin
    • , Zhaohui S Qin
    • , Shihua Li
    •  & Xiao-Jiang Li
  • Article
    | Open Access

    Neuronal identity maintenance is highly regulated. Here, the authors showed that CBP and p300 safeguard neuronal identity through histone acetylation at promoters and enhancers of neuronal specific genes. The loss of both CBP and p300 impairs gene expression, circuit activity, and behavior in mice.

    • Michal Lipinski
    • , Rafael Muñoz-Viana
    • , Beatriz del Blanco
    • , Angel Marquez-Galera
    • , Juan Medrano-Relinque
    • , José M. Caramés
    • , Andrzej A. Szczepankiewicz
    • , Jordi Fernandez-Albert
    • , Carmen M. Navarrón
    • , Roman Olivares
    • , Grzegorz M. Wilczyński
    • , Santiago Canals
    • , Jose P. Lopez-Atalaya
    •  & Angel Barco
  • Article
    | Open Access

    The consequences of postnatal Zika infection are not fully understood. Here, the authors show that postnatal Zika infection in infant rhesus macaques alters neurodevelopment resulting in social, cognitive and motor impairments, as well as structural and functional changes in the brain.

    • Jessica Raper
    • , Zsofia Kovacs-Balint
    • , Maud Mavigner
    • , Sanjeev Gumber
    • , Mark W. Burke
    • , Jakob Habib
    • , Cameron Mattingly
    • , Damien Fair
    • , Eric Earl
    • , Eric Feczko
    • , Martin Styner
    • , Sherrie M. Jean
    • , Joyce K. Cohen
    • , Mehul S. Suthar
    • , Mar M. Sanchez
    • , Maria C. Alvarado
    •  & Ann Chahroudi
  • Article
    | Open Access

    Thalamic head direction (HD) cells are necessary to establish spatial maps in the hippocampus. Here, the authors show that HD cells tuned to a particular direction are coupled to individual hippocampal ripple events during sleep, suggesting an influence of the replay of specific trajectories during sleep memory consolidation.

    • Guillaume Viejo
    •  & Adrien Peyrache
  • Article
    | Open Access

    METTL2 methyltransferase is responsible for 3-methylcytosine modification of arginine tRNAs in mammals. Here the authors show that DALR anticodon binding domain containing 3 (DALRD3) forms a complex with METTL2 to recognize specific arginine tRNAs and find DALRD3 mutations in patients with developmental delay and early-onset epileptic encephalopathy.

    • Jenna M. Lentini
    • , Hessa S. Alsaif
    • , Eissa Faqeih
    • , Fowzan S. Alkuraya
    •  & Dragony Fu
  • Article
    | Open Access

    How does the brain represent sensory uncertainty? The authors find that neural gain variability tracks stimulus uncertainty across the visual hierarchy and explain their findings with a simple generalization of canonical models of neural computation.

    • Olivier J. Hénaff
    • , Zoe M. Boundy-Singer
    • , Kristof Meding
    • , Corey M. Ziemba
    •  & Robbe L. T. Goris
  • Article
    | Open Access

    Following ischemic insult, neovascularization and vascular remodelling play an essential part in the repair of brain damage. Here the authors show that neutrophil extracellular traps serve a detrimental role in the regeneration process, limiting the functional recovery of the brain post injury.

    • Lijing Kang
    • , Huilin Yu
    • , Xing Yang
    • , Yuanbo Zhu
    • , Xiaofei Bai
    • , Ranran Wang
    • , Yongliang Cao
    • , Haochen Xu
    • , Haiyu Luo
    • , Lu Lu
    • , Mei-Juan Shi
    • , Yujing Tian
    • , Wenying Fan
    •  & Bing-Qiao Zhao
  • Article
    | Open Access

    Chronic pain usually induces anxiety. Here, the authors report that vmPFC nNOS-expressing neurons are activated by excitatory inputs from pPVT during chronic pain and subsequently induce anxiety-like behaviors in mice through promoting AMPAR trafficking.

    • Hai-Ying Liang
    • , Zhi-Jin Chen
    • , Hui Xiao
    • , Yu-Hui Lin
    • , Ying-Yi Hu
    • , Lei Chang
    • , Hai-Yin Wu
    • , Peng Wang
    • , Wei Lu
    • , Dong-Ya Zhu
    •  & Chun-Xia Luo
  • Article
    | Open Access

    Defects in DNA repair have been linked to brain aging and neurodegenerative disorders. Here the authors reveal a role for HDAC1 in stimulating OGG1 activity to alleviate 8-oxoG lesions with implications in the aging brain and neurodegenerative diseases.

    • Ping-Chieh Pao
    • , Debasis Patnaik
    • , L. Ashley Watson
    • , Fan Gao
    • , Ling Pan
    • , Jun Wang
    • , Chinnakkaruppan Adaikkan
    • , Jay Penney
    • , Hugh P. Cam
    • , Wen-Chin Huang
    • , Lorena Pantano
    • , Audrey Lee
    • , Alexi Nott
    • , Trongha X. Phan
    • , Elizabeta Gjoneska
    • , Sara Elmsaouri
    • , Stephen J. Haggarty
    •  & Li-Huei Tsai
  • Article
    | Open Access

    We show that the human hippocampus exhibits two distinct theta oscillations during spatial navigation with the faster oscillation in posterior regions showing movement modulation. This result suggests a distinct feature of the human hippocampus compared to rodents, which generally show a single 8 Hz rhythm.

    • Abhinav Goyal
    • , Jonathan Miller
    • , Salman E. Qasim
    • , Andrew J. Watrous
    • , Honghui Zhang
    • , Joel M. Stein
    • , Cory S. Inman
    • , Robert E. Gross
    • , Jon T. Willie
    • , Bradley Lega
    • , Jui-Jui Lin
    • , Ashwini Sharan
    • , Chengyuan Wu
    • , Michael R. Sperling
    • , Sameer A. Sheth
    • , Guy M. McKhann
    • , Elliot H. Smith
    • , Catherine Schevon
    •  & Joshua Jacobs
  • Article
    | Open Access

    Calcium imaging has been used to visualize the activity of individual synapses, but cannot be scaled up to monitor thousands of synapses in tissue. Here, the authors present genetic tools that can be photoconverted from green to red to create a map of active synapses.

    • Alberto Perez-Alvarez
    • , Brenna C. Fearey
    • , Ryan J. O’Toole
    • , Wei Yang
    • , Ignacio Arganda-Carreras
    • , Paul J. Lamothe-Molina
    • , Benjamien Moeyaert
    • , Manuel A. Mohr
    • , Lauren C. Panzera
    • , Christian Schulze
    • , Eric R. Schreiter
    • , J. Simon Wiegert
    • , Christine E. Gee
    • , Michael B. Hoppa
    •  & Thomas G. Oertner
  • Article
    | Open Access

    Goal directed behavior requires the sequential retrieval and evaluation of the multiple choices for action and their deterministic outcomes. Here, the authors report sequential, decodable probabilistic outcome representations in magnetoencephalography (MEG) signals during a risky foraging task.

    • Giuseppe Castegnetti
    • , Athina Tzovara
    • , Saurabh Khemka
    • , Filip Melinščak
    • , Gareth R. Barnes
    • , Raymond J. Dolan
    •  & Dominik R. Bach
  • Article
    | Open Access

    Trajectory-coding neurons in the hippocampus convey important information for performing memory tasks. Here, Kinsky et al. track long-term neural activity in the hippocampus to find that trajectory-coding emerges rapidly and remains stable across long time-scales.

    • Nathaniel R. Kinsky
    • , William Mau
    • , David W. Sullivan
    • , Samuel J. Levy
    • , Evan A. Ruesch
    •  & Michael E. Hasselmo
  • Article
    | Open Access

    Kinesins regulate intracellular transport and microtubule dynamics. Here, the authors show that KIF21B variants in humans associate with corpus callosum agenesis and microcephaly. Using mice and zebrafish, they showed the cellular mechanisms altered by the missense KIF21B variants.

    • Laure Asselin
    • , José Rivera Alvarez
    • , Solveig Heide
    • , Camille S. Bonnet
    • , Peggy Tilly
    • , Hélène Vitet
    • , Chantal Weber
    • , Carlos A. Bacino
    • , Kristin Baranaño
    • , Anna Chassevent
    • , Amy Dameron
    • , Laurence Faivre
    • , Neil A. Hanchard
    • , Sonal Mahida
    • , Kirsty McWalter
    • , Cyril Mignot
    • , Caroline Nava
    • , Agnès Rastetter
    • , Haley Streff
    • , Christel Thauvin-Robinet
    • , Marjan M. Weiss
    • , Gladys Zapata
    • , Petra J. G. Zwijnenburg
    • , Frédéric Saudou
    • , Christel Depienne
    • , Christelle Golzio
    • , Delphine Héron
    •  & Juliette D. Godin
  • Article
    | Open Access

    Working memory training reshapes the brain functional network reorganization. Here, the authors demonstrate an increase of the whole-brain network segregation during the n-back task, accompanied by alterations in dynamic communication between the default mode system and task-positive systems.

    • Karolina Finc
    • , Kamil Bonna
    • , Xiaosong He
    • , David M. Lydon-Staley
    • , Simone Kühn
    • , Włodzisław Duch
    •  & Danielle S. Bassett
  • Article
    | Open Access

    Deep brain stimulation (DBS) is a symptomatic treatment of Parkinson’s disease (PD) that benefits only a minority of patients. Here, the authors show that activation of cortical somatostatin interneurons alleviates motor symptoms in a mouse model of PD and may constitute a less invasive alternative than DBS.

    • Sébastien Valverde
    • , Marie Vandecasteele
    • , Charlotte Piette
    • , Willy Derousseaux
    • , Giuseppe Gangarossa
    • , Asier Aristieta Arbelaiz
    • , Jonathan Touboul
    • , Bertrand Degos
    •  & Laurent Venance
  • Article
    | Open Access

    How the development of the cochlear epithelium is regulated is unclear. Here, the authors use single cell RNAseq analysis to provide insight into the transcriptional changes arising during development of the murine cochlear inner and outer hair cells.

    • Likhitha Kolla
    • , Michael C. Kelly
    • , Zoe F. Mann
    • , Alejandro Anaya-Rocha
    • , Kathryn Ellis
    • , Abigail Lemons
    • , Adam T. Palermo
    • , Kathy S. So
    • , Joseph C. Mays
    • , Joshua Orvis
    • , Joseph C. Burns
    • , Ronna Hertzano
    • , Elizabeth C. Driver
    •  & Matthew W. Kelley
  • Article
    | Open Access

    Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity and higher plasma CRP.

    • Shivani Bhatt
    • , Ansel T. Hillmer
    • , Matthew J. Girgenti
    • , Aleksandra Rusowicz
    • , Michael Kapinos
    • , Nabeel Nabulsi
    • , Yiyun Huang
    • , David Matuskey
    • , Gustavo A. Angarita
    • , Irina Esterlis
    • , Margaret T. Davis
    • , Steven M. Southwick
    • , Matthew J. Friedman
    • , Matthew J. Girgenti
    • , Matthew J. Friedman
    • , Ronald S. Duman
    • , John H. Krystal
    • , Ronald S. Duman
    • , Richard E. Carson
    • , John H. Krystal
    • , Robert H. Pietrzak
    •  & Kelly P. Cosgrove
  • Article
    | Open Access

    Neuronal sphingosine kinase 1 (SphK1) acetylates COX2 which is needed for microglial phagocytosis activity, and release of pro-resolving mediators (SPMs) from neurons. Here the authors examine how SphK1-mediates COX2 acetylation, and how this leads to increased secretion of SPMs from neurons in the context of Alzheimer’s disease models.

    • Ju Youn Lee
    • , Seung Hoon Han
    • , Min Hee Park
    • , Im-Sook Song
    • , Min-Koo Choi
    • , Eunsoo Yu
    • , Cheol-Min Park
    • , Hee-Jin Kim
    • , Seung Hyun Kim
    • , Edward H. Schuchman
    • , Hee Kyung Jin
    •  & Jae-sung Bae
  • Article
    | Open Access

    Humans explore the world by optimistically directing choices to less familiar options and by choosing more randomly when options are uncertain. Here, the authors show that these two exploration strategies rely on distinct uncertainty estimates represented in different parts of the prefrontal cortex.

    • Momchil S. Tomov
    • , Van Q. Truong
    • , Rohan A. Hundia
    •  & Samuel J. Gershman
  • Article
    | Open Access

    The cognitive computational mechanisms underlying the antidepressant treatment response of SSRIs is not well understood. Here the authors show that SSRI treatment in healthy subjects for a week manifests as an amplification of the perception of positive outcomes when learning occurs in a positive mood setting.

    • Jochen Michely
    • , Eran Eldar
    • , Ingrid M. Martin
    •  & Raymond J. Dolan
  • Article
    | Open Access

    Dysfunction of GABAergic neurons in the prefrontal cortex has been reported in schizophrenia. Here, the authors use the apomorphine-susceptible rat, which displays some schizophrenia-like behaviors, and show that interneurons in the medial prefrontal cortex are hypomyelinated, which may contribute to this behavioral phenotype.

    • Dorien A. Maas
    • , Vivian D. Eijsink
    • , Marcia Spoelder
    • , Josephus A. van Hulten
    • , Peter De Weerd
    • , Judith R. Homberg
    • , Astrid Vallès
    • , Brahim Nait-Oumesmar
    •  & Gerard J. M. Martens
  • Article
    | Open Access

    Loss of function of Nav1.7 leads to congenital insensitivity to pain in humans. Here the authors found that activation of Nav1.9 can restore nociception in Nav1.7 knockout mice, revealed by a venom-derived peptide as a probe.

    • Xi Zhou
    • , Tingbin Ma
    • , Luyao Yang
    • , Shuijiao Peng
    • , Lulu Li
    • , Zhouquan Wang
    • , Zhen Xiao
    • , Qingfeng Zhang
    • , Li Wang
    • , Yazhou Huang
    • , Minzhi Chen
    • , Songping Liang
    • , Xianwei Zhang
    • , Jing Yu Liu
    •  & Zhonghua Liu
  • Article
    | Open Access

    Self-grooming is a frequently observed repetitive behaviour in rodents that is believed to contribute to post-stress de-arousal. The authors identified a previously unknown limbic circuit that includes the ventral lateral septum in rats and is involved in regulating stress-induced self-grooming.

    • Ming-Dao Mu
    • , Hong-Yan Geng
    • , Kang-Lin Rong
    • , Rong-Chao Peng
    • , Shu-Ting Wang
    • , Lin-Ting Geng
    • , Zhong-Ming Qian
    • , Wing-Ho Yung
    •  & Ya Ke
  • Article
    | Open Access

    Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

    • Xueyi Shen
    • , David M. Howard
    • , Mark J. Adams
    • , W. David Hill
    • , Toni-Kim Clarke
    • , Mark J. Adams
    • , Toni-Kim Clarke
    • , Andrew M. McIntosh
    • , Ian J. Deary
    • , Naomi R. Wray
    • , Stephan Ripke
    • , Manuel Mattheisen
    • , Maciej Trzaskowski
    • , Enda M. Byrne
    • , Abdel Abdellaoui
    • , Esben Agerbo
    • , Tracy M. Air
    • , Till F. M. Andlauer
    • , Silviu-Alin Bacanu
    • , Marie Bækvad-Hansen
    • , Aartjan T. F. Beekman
    • , Tim B. Bigdeli
    • , Elisabeth B. Binder
    • , Julien Bryois
    • , Henriette N. Buttenschøn
    • , Jonas Bybjerg-Grauholm
    • , Na Cai
    • , Enrique Castelao
    • , Jane Hvarregaard Christensen
    • , Jonathan R. I. Coleman
    • , Lucía Colodro-Conde
    • , Baptiste Couvy-Duchesne
    • , Nick Craddock
    • , Gregory E. Crawford
    • , Gail Davies
    • , Franziska Degenhardt
    • , Eske M. Derks
    • , Nese Direk
    • , Conor V. Dolan
    • , Erin C. Dunn
    • , Thalia C. Eley
    • , Valentina Escott-Price
    • , Farnush Farhadi Hassan Kiadeh
    • , Hilary K. Finucane
    • , Jerome C. Foo
    • , Andreas J. Forstner
    • , Josef Frank
    • , Héléna A. Gaspar
    • , Michael Gill
    • , Fernando S. Goes
    • , Scott D. Gordon
    • , Jakob Grove
    • , Lynsey S. Hall
    • , Christine Søholm Hansen
    • , Thomas F. Hansen
    • , Stefan Herms
    • , Ian B. Hickie
    • , Per Hoffmann
    • , Georg Homuth
    • , Carsten Horn
    • , Jouke-Jan Hottenga
    • , David M. Hougaard
    • , David M. Howard
    • , Marcus Ising
    • , Rick Jansen
    • , Ian Jones
    • , Lisa A. Jones
    • , Eric Jorgenson
    • , James A. Knowles
    • , Isaac S. Kohane
    • , Julia Kraft
    • , Warren W. Kretzschmar
    • , Zoltán Kutalik
    • , Yihan Li
    • , Penelope A. Lind
    • , Donald J. MacIntyre
    • , Dean F. MacKinnon
    • , Robert M. Maier
    • , Wolfgang Maier
    • , Jonathan Marchini
    • , Hamdi Mbarek
    • , Patrick McGrath
    • , Peter McGuffin
    • , Sarah E. Medland
    • , Divya Mehta
    • , Christel M. Middeldorp
    • , Evelin Mihailov
    • , Yuri Milaneschi
    • , Lili Milani
    • , Francis M. Mondimore
    • , Grant W. Montgomery
    • , Sara Mostafavi
    • , Niamh Mullins
    • , Matthias Nauck
    • , Bernard Ng
    • , Michel G. Nivard
    • , Dale R. Nyholt
    • , Paul F. O’Reilly
    • , Hogni Oskarsson
    • , Michael J. Owen
    • , Jodie N. Painter
    • , Carsten Bøcker Pedersen
    • , Marianne Giørtz Pedersen
    • , Roseann E. Peterson
    • , Erik Pettersson
    • , Wouter J. Peyrot
    • , Giorgio Pistis
    • , Danielle Posthuma
    • , Jorge A. Quiroz
    • , Per Qvist
    • , John P. Rice
    • , Brien P. Riley
    • , Margarita Rivera
    • , Saira Saeed Mirza
    • , Robert Schoevers
    • , Eva C. Schulte
    • , Ling Shen
    • , Jianxin Shi
    • , Stanley I. Shyn
    • , Engilbert Sigurdsson
    • , Grant C. B. Sinnamon
    • , Johannes H. Smit
    • , Daniel J. Smith
    • , Hreinn Stefansson
    • , Stacy Steinberg
    • , Fabian Streit
    • , Jana Strohmaier
    • , Katherine E. Tansey
    • , Henning Teismann
    • , Alexander Teumer
    • , Wesley Thompson
    • , Pippa A. Thomson
    • , Thorgeir E. Thorgeirsson
    • , Matthew Traylor
    • , Jens Treutlein
    • , Vassily Trubetskoy
    • , Andrés G. Uitterlinden
    • , Daniel Umbricht
    • , Sandra Van der Auwera
    • , Albert M. van Hemert
    • , Alexander Viktorin
    • , Peter M. Visscher
    • , Yunpeng Wang
    • , Bradley T. Webb
    • , Shantel Marie Weinsheimer
    • , Jürgen Wellmann
    • , Gonneke Willemsen
    • , Stephanie H. Witt
    • , Yang Wu
    • , Hualin S. Xi
    • , Jian Yang
    • , Futao Zhang
    • , Volker Arolt
    • , Bernhard T. Baune
    • , Klaus Berger
    • , Dorret I. Boomsma
    • , Sven Cichon
    • , Udo Dannlowski
    • , E. J. C. de Geus
    • , J. Raymond DePaulo
    • , Enrico Domenici
    • , Katharina Domschke
    • , Tõnu Esko
    • , Hans J. Grabe
    • , Steven P. Hamilton
    • , Caroline Hayward
    • , Andrew C. Heath
    • , Kenneth S. Kendler
    • , Stefan Kloiber
    • , Glyn Lewis
    • , Qingqin S. Li
    • , Susanne Lucae
    • , Pamela A. F. Madden
    • , Patrik K. Magnusson
    • , Nicholas G. Martin
    • , Andres Metspalu
    • , Ole Mors
    • , Preben Bo Mortensen
    • , Bertram Müller-Myhsok
    • , Merete Nordentoft
    • , Markus M. Nöthen
    • , Michael C. O’Donovan
    • , Sara A. Paciga
    • , Nancy L. Pedersen
    • , Brenda W. J. H. Penninx
    • , Roy H. Perlis
    • , David J. Porteous
    • , James B. Potash
    • , Martin Preisig
    • , Marcella Rietschel
    • , Catherine Schaefer
    • , Thomas G. Schulze
    • , Jordan W. Smoller
    • , Kari Stefansson
    • , Henning Tiemeier
    • , Rudolf Uher
    • , Henry Völzke
    • , Myrna M. Weissman
    • , Thomas Werge
    • , Cathryn M. Lewis
    • , Douglas F. Levinson
    • , Gerome Breen
    • , Anders D. Børglum
    • , Patrick F. Sullivan
    • , Ian J. Deary
    • , Heather C. Whalley
    •  & Andrew M. McIntosh
  • Article
    | Open Access

    Dysregulated prefrontal control over amygdala has been implicated in the etiology of stress-related psychiatric disorders. Here, the authors show that the dysregulation preferentially occurs in amygdala neurons that are mono- but not bi-directionally connected with dorsomedial prefrontal cortex.

    • Wei-Zhu Liu
    • , Wen-Hua Zhang
    • , Zhi-Heng Zheng
    • , Jia-Xin Zou
    • , Xiao-Xuan Liu
    • , Shou-He Huang
    • , Wen-Jie You
    • , Ye He
    • , Jun-Yu Zhang
    • , Xiao-Dong Wang
    •  & Bing-Xing Pan
  • Article
    | Open Access

    Theta oscillations have been implicated in hippocampal processing but mechanisms constraining phase timing of specific cell types are unknown. Here, the authors combine single-cell and multisite recordings with evolutionary computational models to evaluate mechanisms of phase preference of deep and superficial CA1 pyramidal cells.

    • Andrea Navas-Olive
    • , Manuel Valero
    • , Teresa Jurado-Parras
    • , Adan de Salas-Quiroga
    • , Robert G. Averkin
    • , Giuditta Gambino
    • , Elena Cid
    •  & Liset M. de la Prida
  • Article
    | Open Access

    Exercise promotes motor skill learning via unclear mechanisms. Here, the authors show that running wheel training results in neurotransmitter switching in caudal pedunculopontine nucleus neurons of mice. These neurons project to several brain regions, regulating the acquisition of motor skills.

    • Hui-quan Li
    •  & Nicholas C. Spitzer
  • Article
    | Open Access

    The physiological role of the olfactory marker protein (OMP) has been elusive. Here, the authors demonstrate that OMP buffers cAMP and modulates cAMP-gated channel activity upon sensory stimulation, maintaining neuronal firing during odour-source searching.

    • Noriyuki Nakashima
    • , Kie Nakashima
    • , Akiko Taura
    • , Akiko Takaku-Nakashima
    • , Harunori Ohmori
    •  & Makoto Takano
  • Article
    | Open Access

    The regeneration dynamics following peripheral nerve injury differs among species. Here, the authors compared transcriptomic and lipid metabolism changes in murine and human Schwann cells in vivo and ex vivo sural nerves, underlying their switch from myelinating to repair state following injury.

    • Sofia Meyer zu Reckendorf
    • , Christine Brand
    • , Maria T. Pedro
    • , Jutta Hegler
    • , Corinna S. Schilling
    • , Raissa Lerner
    • , Laura Bindila
    • , Gregor Antoniadis
    •  & Bernd Knöll