Featured
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Article |
Cortical reactivations predict future sensory responses
Offline cortical reactivations predict the gradual drift and separation in sensory cortical response patterns and may enhance sensory discrimination.
- Nghia D. Nguyen
- , Andrew Lutas
- & Mark L. Andermann
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Editorial |
Why mega brain project teams need to be talking to each other
As large-scale neuroscience projects start to yield results, sharing data standards will become increasingly important.
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Spotlight |
I study depression in the lab and advocate for mental health in academia
Annapoorna P. K. tells Nature about her work on understanding depression both in and outside the lab.
- Pratik Pawar
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News & Views Forum |
Cellular atlases of the entire mouse brain
In a huge collaborative effort, millions of cells in the mouse brain have been mapped in detail. Two scientists examine the resulting wealth of insights into gene regulation in brain cells, neuronal connections and how our own brains evolved.
- Maria Antonietta Tosches
- & Heather J. Lee
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News |
How our brains decode speech: special neurons process certain sounds
Wire-thin probes inserted into the brains of living people show the parts played by individual neurons.
- Saima Sidik
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News |
Neurons responsible for poor sleep and stress found in mice
Frightened mice sleep poorly. Researchers have identified at least some of the neurons responsible.
- Jude Coleman
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Article
| Open Access
Dynamic behaviour restructuring mediates dopamine-dependent credit assignment
Initial dopamine self-stimulations reinforced not only the stimulation-producing target action, but also actions similar to the target action and actions that occurred a few seconds before stimulation, and repeated pairings led to a gradual refinement of the behavioural repertoire to home in on the target actions.
- Jonathan C. Y. Tang
- , Vitor Paixao
- & Rui M. Costa
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Article
| Open Access
Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain
Methylome-based clustering and cross-modality integration with companion datasets from the BRAIN Initiative Cell Census Network enabled the construction of a 3D multi-omic genome atlas of the adult mouse brain featuring thousands of cell-type-specific profiles.
- Hanqing Liu
- , Qiurui Zeng
- & Joseph R. Ecker
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Article
| Open Access
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions.
- Zizhen Yao
- , Cindy T. J. van Velthoven
- & Hongkui Zeng
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Article
| Open Access
A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons
In this study, the authors develop a comprehensive taxonomy of brain-wide SPNs, identifying several novel subsets via their transcriptional signatures.
- Carla C. Winter
- , Anne Jacobi
- & Zhigang He
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Article
| Open Access
Large-scale single-neuron speech sound encoding across the depth of human cortex
High-density single-neuron recordings show diverse tuning for acoustic and phonetic features across layers in human auditory speech cortex.
- Matthew K. Leonard
- , Laura Gwilliams
- & Edward F. Chang
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Article
| Open Access
Molecularly defined and spatially resolved cell atlas of the whole mouse brain
A comprehensive cell atlas of the whole mouse brain with high molecular and spatial resolution is generated.
- Meng Zhang
- , Xingjie Pan
- & Xiaowei Zhuang
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Article
| Open Access
Conserved and divergent gene regulatory programs of the mammalian neocortex
A single-cell multiomics analysis of over 200,000 cells of the primary motor cortex of human, macaque, marmoset and mouse shows that divergence of transcription factor expression corresponds to species-specific epigenome landscapes, and conserved and divergent gene regulatory features are reflected in the evolution of the three-dimensional genome.
- Nathan R. Zemke
- , Ethan J. Armand
- & Bing Ren
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Article
| Open Access
Evolution of neuronal cell classes and types in the vertebrate retina
Single-cell and single-nucleus transcriptomic analysis of retina from 17 vertebrate species shows high conservation of retinal cell types and suggests that midget retinal ganglion cells in primates evolved from orthologous cells in ancestral mammals.
- Joshua Hahn
- , Aboozar Monavarfeshani
- & Karthik Shekhar
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Article
| Open Access
Single-cell analysis of chromatin accessibility in the adult mouse brain
An atlas of candidate cis-regulatory DNA elements (cCREs) in the adult mouse brain unravels the transcriptional regulatory programs that drive the heterogeneity and complexity of brain structure and function.
- Songpeng Zu
- , Yang Eric Li
- & Bing Ren
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Article
| Open Access
The molecular cytoarchitecture of the adult mouse brain
To construct a comprehensive atlas of cell types in each brain structure, we paired high-throughput single-nucleus RNA sequencing with Slide-seq, a recently developed spatial transcriptomics method with near-cellular resolution, across the entire mouse brain.
- Jonah Langlieb
- , Nina S. Sachdev
- & Evan Z. Macosko
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Article
| Open Access
Brain-wide correspondence of neuronal epigenomics and distant projections
This study uses epi-retro-seq to link single-cell epigenomes and cell types to long-distance projections for neurons dissected from different regions projecting to different targets across the whole mouse brain.
- Jingtian Zhou
- , Zhuzhu Zhang
- & Edward M. Callaway
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Article |
A molecular switch for neuroprotective astrocyte reactivity
The authors identify a molecular switch that regulates the balance between neurotoxic and neuroprotective astrocyte populations, with potential application in the treatment of glaucoma and other optic neuropathies.
- Evan G. Cameron
- , Michael Nahmou
- & Jeffrey L. Goldberg
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Research Highlight |
Wee VR googles give mice a true immersive experience
Headset could make it easier to study reactions in the animals’ brains to simulated situations.
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Book Review |
The unsung geniuses who uncovered why we sleep and dream
Just 100 years ago, we understood astoundingly little about sleep and dreaming. A tight-knit band of researchers changed things, against sometimes considerable odds.
- Jennifer L. Martin
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News Feature |
Is cannabis bad for teens? Here’s what the data say
Ten years after cannabis was first legalized for casual use in adults, scientists are struggling to provide evidence-based recommendations about the risks to young people.
- Anil Oza
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News |
How CRISPR gene editing could help treat Alzheimer’s
Some researchers hoping that gene-editing technology can conquer forms of Alzheimer’s caused by genetic mutations.
- Tosin Thompson
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Article
| Open Access
TAF15 amyloid filaments in frontotemporal lobar degeneration
Cryogenic electron microscopy structures of amyloid filaments extracted from patient brains reveal that the protein TAF15 forms filaments that characterize certain cases of frontotemporal lobar degeneration.
- Stephan Tetter
- , Diana Arseni
- & Benjamin Ryskeldi-Falcon
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News |
Brain implants help people to recover after severe head injury
Electrodes placed inside the brains of five people with traumatic injuries improved recipients’ performance in attention and memory tests.
- Miryam Naddaf
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Article
| Open Access
Cellular development and evolution of the mammalian cerebellum
Single-nucleus RNA-sequencing data from the cerebellum of human, mouse and opossum is used to analyse the developmental dynamics of cell types and states in mammalian cerebellum and provide evolutionary insights.
- Mari Sepp
- , Kevin Leiss
- & Henrik Kaessmann
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Article
| Open Access
Disease-specific tau filaments assemble via polymorphic intermediates
A time-resolved cryogenic electron microscopy analysis provides structural information on the processes of primary and secondary nucleation of tau amyloid formation, with implications for the development of new therapies.
- Sofia Lövestam
- , David Li
- & Sjors H. W. Scheres
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News |
This sparrow massively expands part of its brain in preparation for mating
The trick baffles researchers — but they are getting closer to understanding how the songbird does it.
- Anil Oza
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News |
These brain cells could influence how fast you eat — and when you stop
Scientists found the cells in mice — and say they could lead to a better understanding of human appetite.
- Carissa Wong
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News & Views |
Ancient DNA uncovers past migrations in California
Genomic data from ancient humans who lived up to 7,400 years ago, sampled from across California and Mexico, unveil patterns of migration that could explain how some Indigenous languages spread in parts of North America.
- Alan Izarraras-Gomez
- & Diego Ortega-Del Vecchyo
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Article
| Open Access
Sequential appetite suppression by oral and visceral feedback to the brainstem
Genetically distinct neural circuits in the caudal brainstem receive feedback from the mouth and gut to regulate feeding behaviour on short and long timescales.
- Truong Ly
- , Jun Y. Oh
- & Zachary A. Knight
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World View |
Only 0.5% of neuroscience studies look at women’s health. Here’s how to change that
A new initiative challenges the severe neglect of women’s brain health from puberty through to pregnancy and menopause.
- Emily G. Jacobs
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News |
Wi-Fi for neurons: first map of wireless nerve signals unveiled in worms
Studies find a densely connected network of neurons that communicate over long distances, rather than across synapses.
- Claudia López Lloreda
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News |
CRISPR and ‘e-ink’: new tools could reveal the secrets of cuttlefish camouflage
Technology moves scientists closer than ever to understanding how colour-blind cuttlefish pull off their kaleidoscopic patterns.
- Max Kozlov
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Article |
Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema
Acute oedema after traumatic brain injury is accompanied by the suppression of glymphatic and lymphatic fluid flow due to excessive systemic release of noradrenaline.
- Rashad Hussain
- , Jeffrey Tithof
- & Maiken Nedergaard
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News |
AI that reads brain scans shows promise for finding Alzheimer’s genes
Machine-learning approach detects Alzheimer’s disease with an accuracy of more than 90% — a potential boon for clinicians and scientists developing treatments.
- Max Kozlov
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Research Highlight |
One brain area helps you to enjoy a joke — but another helps you to get it
Seinfeld episodes help scientists to distinguish between the brain regions involved in understanding and appreciating humour.
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Perspective |
Functional neuroimaging as a catalyst for integrated neuroscience
This Perspective reviews successful applications of functional magnetic resonance imaging (fMRI) and presents a case for fMRI as a central hub on which to integrate the dispersed subfields of systems, cognitive, computational and clinical neuroscience.
- Emily S. Finn
- , Russell A. Poldrack
- & James M. Shine
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Editorial |
Brain and body are more intertwined than we knew
A host of disorders once thought to be nothing to do with the brain are, in fact, tightly coupled to nervous-system activity.
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Article
| Open Access
Preserved neural dynamics across animals performing similar behaviour
Recordings of neural populations from motor cortex and striatum spanning monkeys and mice demonstrate that neural dynamics in individuals from the same species are preserved when they perform similar behaviour.
- Mostafa Safaie
- , Joanna C. Chang
- & Juan A. Gallego
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News Feature |
The rise of brain-reading technology: what you need to know
As implanted devices and commercial headsets advance, what will the real-world impacts be?
- Liam Drew
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Article
| Open Access
Neural landscape diffusion resolves conflicts between needs across time
Behavioural and electrophysiological studies in simultaneously thirsty and hungry mice reveal a neural basis for resolving conflicts between needs, in which choices are guided by a persistent and distributed neural goal state that undergoes spontaneous transitions between goals.
- Ethan B. Richman
- , Nicole Ticea
- & Liqun Luo
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Perspective |
Functional genomics and systems biology in human neuroscience
Technical developments and large collaborative research networks in neurogenomics promise rapid progress in neuroscience, but translation of results from model systems to human brains is limited by sample availability, technical challenges and ethical issues.
- Genevieve Konopka
- & Aparna Bhaduri
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Article
| Open Access
m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration
TDP-43 binds to N1-methyladenosine on CAG repeat RNA, resulting in the formation of gel-like TDP-43 aggregates in the cytoplasm that resemble those observed in neurological disease pathology.
- Yuxiang Sun
- , Hui Dai
- & Yinsheng Wang
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Comment |
How AI could lead to a better understanding of the brain
Early machine-learning systems were inspired by neural networks — now AI might allow neuroscientists to get to grips with the brain’s unique complexities.
- Viren Jain
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News |
Spinal implant helps man with advanced Parkinson’s to walk without falling
Electrical stimulation improved his mobility, although researchers say that a larger study is needed to assess the device.
- Emily Waltz
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News & Views |
Brain cancer thrives by hijacking mechanisms to boost synapse strength
Synaptic connections between cancer cells and neurons can boost tumour growth. Analyses of brain tumours reveal how cancer cells enhance the strength of synapses with neurons to promote tumour survival.
- Matthew B. Dalva
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News |
Coffee in stereo: your brain records an odour’s spatial information
Scent information from the two nostrils leads to two types of neural activity.
- Saima Sidik
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Research Briefing |
Identification of neuronal connections between heart and brain that trigger fainting
The neural pathways involved in syncope, or fainting, are not well understood. Studies in mice have identified a defined subset of vagal sensory neurons that connect the heart and brain. Stimulation of these neurons causes reduced heart rate, blood pressure, breathing and neuronal activity in the brain, resulting in syncope.
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News |
What causes fainting? Scientists finally have an answer
Mouse experiments reveal the brain–heart connections that cause us to lose consciousness rapidly — and wake up moments later.
- Miryam Naddaf
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