Nature Podcast |
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Matters Arising |
Ptbp1 deletion does not induce astrocyte-to-neuron conversion
- Thanh Hoang
- , Dong Won Kim
- & Seth Blackshaw
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Outlook |
Brain-zapping technology helps smokers to quit
Repetitive transcranial magnetic stimulation is already approved to help people overcome addiction to cigarettes, but researchers still have a lot to learn about how to deliver the treatment effectively.
- Simon Makin
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Research Briefing |
A battle between neural circuits for infanticide and maternal-care behaviours
A previously unknown neural circuit in the brains of female mice is activated during infanticidal behaviour, and reciprocally inhibits another circuit that promotes maternal-care behaviour. These circuits show opposing changes in excitability when female mice become mothers, explaining the switch in young-directed behaviours that occurs with motherhood.
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Matters Arising |
Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion
- Yajing Hao
- , Jing Hu
- & Xiang-Dong Fu
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Article |
Antagonistic circuits mediating infanticide and maternal care in female mice
ESR1-expressing cells in the principal nucleus of the bed nucleus of stria terminalis are necessary, sufficient and naturally activated during infanticide, and they form reciprocal inhibition with the maternal cells to control young-directed behaviours in female mice.
- Long Mei
- , Rongzhen Yan
- & Dayu Lin
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News |
Does shingles vaccination cut dementia risk? Large study hints at a link
Analysis of nearly 300,000 people finds an association between the shingles jab and a lower rate of dementia — but questions linger.
- Sara Reardon
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News |
Sleep loss impairs memory of smells, worm research shows
Sleeping C. elegans offers clues to the molecular changes underpinning the link between sleep and memory.
- Miryam Naddaf
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Research Briefing |
The geometry of the human brain shapes its function
Brain activity is structured in space and time. The resulting activity patterns are conventionally thought to depend on an intricate web of anatomical connections that link specialized populations of cells. This work challenges this paradigm by showing that macroscale neuronal dynamics of the human brain are fundamentally shaped by its physical geometry.
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News |
The human brain’s characteristic wrinkles help to drive how it works
A model of the brain’s geometry better explains neuronal activity than a model based on the ‘connectome’.
- Davide Castelvecchi
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Article
| Open Access
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzheimer’s disease.
- Constanze Depp
- , Ting Sun
- & Klaus-Armin Nave
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Article
| Open Access
Geometric constraints on human brain function
Cortical and subcortical activity can be parsimoniously understood as resulting from excitations of fundamental, resonant modes of the brain’s geometry rather than from modes of complex interregional connectivity.
- James C. Pang
- , Kevin M. Aquino
- & Alex Fornito
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Article |
Expertise increases planning depth in human gameplay
A computational model based on a heuristic value function and forward search algorithm predicts human choices, response times and eye movements in games of games of four-in-a-row, and shows evidence for increased planning and improved attention with increased expertise.
- Bas van Opheusden
- , Ionatan Kuperwajs
- & Wei Ji Ma
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News |
Does brain stimulation boost memory and focus? Mega study tries to settle debate
Analysis of more than 100 studies of non-invasive electrical brain stimulation probes whether the controversial technology works.
- Emily Waltz
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News |
Chronic stress can inflame the gut — now scientists know why
Signals originating in the brain make their way to gut nerve cells, leading to a release of inflammatory chemicals.
- Saima Sidik
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Article
| Open Access
Gap junctions desynchronize a neural circuit to stabilize insect flight
In the Drosophila central-pattern-generating neural network, a mechanism for network desynchronization relying on weak electrical synapses and specific excitability dynamics of the coupled neurons translates unpatterned premotor input into stereotyped neuronal firing with fixed sequences of cell activation, ensuring stable wingbeat power.
- Silvan Hürkey
- , Nelson Niemeyer
- & Carsten Duch
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Outlook |
Listening for neurological symptoms
Unusual vocal patterns can give clues that help to detect conditions such as Alzheimer’s disease.
- Michael Eisenstein
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Outlook |
Accelerating drug development with 3D neural models
A reproducible cell-culture system could help to evaluate new therapies for disorders that affect the brain.
- Christine Evans-Pughe
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Clinical Briefing |
A digital bridge between brain and spinal cord restores walking after paralysis
Spinal-cord injury interrupts communication between the brain and spinal cord, leading to paralysis. An implant that decodes the brain signals that control movements and drives electrical stimulation of the spinal cord re-establishes this communication, enabling an individual with spinal-cord injury to walk naturally.
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News |
Brain–spine interface allows paralysed man to walk using his thoughts
The device provides a connection between the brain and spinal cord, allowing thought to control movement.
- Dyani Lewis
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Article
| Open Access
Walking naturally after spinal cord injury using a brain–spine interface
A reliable digital bridge restored communication between the brain and spinal cord and enabled natural walking in a participant with spinal cord injury.
- Henri Lorach
- , Andrea Galvez
- & Grégoire Courtine
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News |
Soft ‘electronic skin’ mimics our sense of touch
A flexible, conductive membrane that can pass sensory information to the brain and muscles is a step towards artificial skin.
- Katharine Sanderson
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Correspondence |
Chronic pain: try new routes to more tailored treatments
- Pablo R. Brumovsky
- , Mariano Asla
- & Marcelo J. Villar
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Technology Feature |
Brain imaging: fMRI advances make scans sharper and faster
Researchers are finding ways to improve one of neuroscientists’ favourite tools: functional magnetic resonance imaging.
- Diana Kwon
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News |
How one man’s rare Alzheimer’s mutation delayed the onset of disease
Genetic resilience found in a person predisposed to early-onset dementia could potentially lead to new treatments.
- Sara Reardon
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News |
Menopause therapy: Brain-based treatment for hot flushes approved by FDA
Investigations into the impact of menopause on the brain have yielded a potential way to treat troublesome symptoms without hormones.
- Heidi Ledford
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News |
Alzheimer’s drug donanemab: what promising trial means for treatments
Results suggest that the amyloid-targeting drug candidate slows cognitive decline in some people, but questions remain over its potential side effects.
- Sara Reardon
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Nature Careers Podcast |
Unlocking the mysteries of the brain’s neocortex
Entrepreneur Jeff Hawkins explains how our knowledge of the brain can help us to better understand artificial intelligence.
- Dom Byrne
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News & Views |
How thought itself can drive tumour growth
Tumour cells can form connections with neurons in the brain. Examination of a variety of types of evidence concerning human brain cancer sheds light on how these tumour–neuron interactions affect cognition and survival times.
- George M. Ibrahim
- & Michael D. Taylor
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Research Briefing |
Brain dynamics uncovered using a machine-learning algorithm
CEBRA is a machine-learning method that can be used to compress time series in a way that reveals otherwise hidden structures in the variability of the data. It excels at processing behavioural and neural data recorded simultaneously, and it can decode activity from the visual cortex of the mouse brain to reconstruct a viewed video.
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Article
| Open Access
Cortico-cortical feedback engages active dendrites in visual cortex
Feedback influence from a higher visual area to primary visual cortex in mice engages nonlinear dendritic integration.
- Mehmet Fişek
- , Dustin Herrmann
- & Michael Häusser
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Article
| Open Access
Glioblastoma remodelling of human neural circuits decreases survival
High-grade gliomas functionally remodel neural circuits in the human brain, promoting tumour progression and impairing cognition.
- Saritha Krishna
- , Abrar Choudhury
- & Shawn L. Hervey-Jumper
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Article
| Open Access
Learnable latent embeddings for joint behavioural and neural analysis
A new encoding method, CEBRA, jointly uses behavioural and neural data in a (supervised) hypothesis- or (self-supervised) discovery-driven manner to produce both consistent and high-performance latent spaces.
- Steffen Schneider
- , Jin Hwa Lee
- & Mackenzie Weygandt Mathis
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News Explainer |
Mind-reading machines are here: is it time to worry?
Neuroethicists are split on whether a study that uses brain scans and AI to decode imagined speech poses a threat to mental privacy.
- Sara Reardon
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Nature Podcast |
Audio long read: Conquering Alzheimer’s — a look at the therapies of the future
Trial successes have raised hopes that the condition might eventually be preventable.
- Alison Abbott
- & Benjamin Thompson
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Nature Podcast |
How Rosalind Franklin’s story was rewritten
Newly discovered documents reveal more about Rosalind Franklin’s role in solving DNA’s structure, and how multisensory experiences can create stronger memories in fruit flies.
- Benjamin Thompson
- & Shamini Bundell
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Nature Careers Podcast |
How trauma’s effects can pass from generation to generation
Neuroepigenetics researcher Isabelle Mansuy investigates how life life experiences and environmental factors can shape not only us, but also our descendants.
- Dom Byrne
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Research Briefing |
How flies remember a rich experience from its individual components
Multisensory information improves subsequent memory performance. In Drosophila flies, learning re-routes activity through neuronal networks in the brain such that individual components of a multisensory experience can trigger retrieval of the memory of the whole event. As a result, memory performance for both the combined and individual components of the experience is improved.
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Article
| Open Access
Multisensory learning binds neurons into a cross-modal memory engram
Multisensory learning improves subsequent memory performance, even for individual sensory cues, in Drosophila.
- Zeynep Okray
- , Pedro F. Jacob
- & Scott Waddell
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Article
| Open Access
Long-range inhibition synchronizes and updates prefrontal task activity
Rule-shift behavioural experiments in mice demonstrate that callosal projections of parvalbumin-expressing neurons switch prefrontal circuits from maintenance mode to rule-learning mode by gating inputs from other callosal inputs that maintain previous rule representations.
- Kathleen K. A. Cho
- , Jingcheng Shi
- & Vikaas S. Sohal
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Article |
Cryptochrome–Timeless structure reveals circadian clock timing mechanisms
Structural analysis of a protein complex in the circadian clock of Drosophila reveals how a light-sensing cryptochrome recognizes and engages its target.
- Changfan Lin
- , Shi Feng
- & Brian R. Crane
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Article |
Inhibitory input directs astrocyte morphogenesis through glial GABABR
Inhibitory neuron activity is necessary and sufficient for astrocyte morphogenesis.
- Yi-Ting Cheng
- , Estefania Luna-Figueroa
- & Benjamin Deneen
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Research Highlight |
Goldfish headgear reveals secrets of fish navigation
Unprecedented pattern of brain activity is recorded in freely swimming fish.
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News |
Drugs give biology’s favourite worms the munchies too
Experiments with C. elegans suggest that the mechanism by which cannabis affects appetite evolved 500 million years ago.
- Elissa Welle
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Article
| Open Access
A somato-cognitive action network alternates with effector regions in motor cortex
Functional MRI studies across ages show that the classic homunculus of the motor cortex in humans is in fact discontinuous, alternating with action control-linked regions termed the somato-cognitive action network.
- Evan M. Gordon
- , Roselyne J. Chauvin
- & Nico U. F. Dosenbach
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News & Views |
A redrawn map for the human motor cortex
The human brain’s motor cortex is often regarded as a linear map with discrete sections, each controlling different parts of the body. The discovery that portions of the motor cortex have other functions points to a different type of map.
- David A. Leopold
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News |
Famous ‘homunculus’ brain map redrawn to include complex movements
Textbook homunculus diagram depicts how the brain controls individual body parts — the revamp could improve treatments for brain injury.
- Max Kozlov
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News Explainer |
Hotly anticipated ALS drug could pave way for more brain treatments
A thumbs-up for tofersen from the US Food and Drug Administration would reinforce the agency’s shifting approach to neurological drugs.
- Asher Mullard
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Article
| Open Access
Dynamic synchronization between hippocampal representations and stepping
Experiments in rats show that spatial representations in the hippocampus are closely coordinated with the forelimb stepping cycle, particularly when spatial decisions are approaching, and provide insight into how this synchronization supports information processing.
- Abhilasha Joshi
- , Eric L. Denovellis
- & Loren M. Frank
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Article
| Open Access
Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms
Analyses of the proteomes of astrocytes and neurons in a cell-specific and subcompartment-specific manner reveal distinct roles for these cell types that are relevant to obsessive–compulsive disorder and perhaps other brain disorders.
- Joselyn S. Soto
- , Yasaman Jami-Alahmadi
- & Baljit S. Khakh
A brain circuit for infanticide, in mice
Ptbp1 deletion does not induce astrocyte-to-neuron conversion
Brain-zapping technology helps smokers to quit
A battle between neural circuits for infanticide and maternal-care behaviours
Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion
Antagonistic circuits mediating infanticide and maternal care in female mice
Does shingles vaccination cut dementia risk? Large study hints at a link
Sleep loss impairs memory of smells, worm research shows
The geometry of the human brain shapes its function
The human brain’s characteristic wrinkles help to drive how it works
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Geometric constraints on human brain function
Expertise increases planning depth in human gameplay
Does brain stimulation boost memory and focus? Mega study tries to settle debate
Chronic stress can inflame the gut — now scientists know why
Gap junctions desynchronize a neural circuit to stabilize insect flight
Listening for neurological symptoms
Accelerating drug development with 3D neural models
A digital bridge between brain and spinal cord restores walking after paralysis
Brain–spine interface allows paralysed man to walk using his thoughts
Walking naturally after spinal cord injury using a brain–spine interface
Soft ‘electronic skin’ mimics our sense of touch
Brain imaging: fMRI advances make scans sharper and faster
How one man’s rare Alzheimer’s mutation delayed the onset of disease
Menopause therapy: Brain-based treatment for hot flushes approved by FDA
Alzheimer’s drug donanemab: what promising trial means for treatments
Unlocking the mysteries of the brain’s neocortex
How thought itself can drive tumour growth
Brain dynamics uncovered using a machine-learning algorithm
Cortico-cortical feedback engages active dendrites in visual cortex
Glioblastoma remodelling of human neural circuits decreases survival
Learnable latent embeddings for joint behavioural and neural analysis
Mind-reading machines are here: is it time to worry?
Audio long read: Conquering Alzheimer’s — a look at the therapies of the future
How Rosalind Franklin’s story was rewritten
How trauma’s effects can pass from generation to generation
How flies remember a rich experience from its individual components
Multisensory learning binds neurons into a cross-modal memory engram
Long-range inhibition synchronizes and updates prefrontal task activity
Cryptochrome–Timeless structure reveals circadian clock timing mechanisms
Inhibitory input directs astrocyte morphogenesis through glial GABABR
Goldfish headgear reveals secrets of fish navigation
Drugs give biology’s favourite worms the munchies too
A somato-cognitive action network alternates with effector regions in motor cortex
A redrawn map for the human motor cortex
Famous ‘homunculus’ brain map redrawn to include complex movements
Hotly anticipated ALS drug could pave way for more brain treatments
Dynamic synchronization between hippocampal representations and stepping
Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanismsBrowse broader subjects
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