Neuronal development articles from across Nature Portfolio

Mitochondria emerged as essential actors of neural circuits development. Here, the authors uncovered that the AMPK-related kinase NUAK1 controls axonal mitochondrial metabolism through the regulation of the mitochondrial microprotein BRAWNIN.

Neonatal brain dynamics are not well understood. Here, the authors characterise brain transient states in neonates, and show that preterm infants display altered whole brain dynamics and an atypical repertoire of regional transient states, which are associated with behavioural outcomes at 18 months of age.

The slow maturation of human neurons is regulated by epigenetic modification in nascent neurons, mediated by EZH2, EHMT1, EHMT2 and DOT1L.

Neurons derived from stem cells are rapidly matured with a GENtoniK cocktail.

A stream of young neurons migrating into the entorhinal cortex (EC) continues postnatally in humans, but not in macaques; these young neurons, which belong to a unique class of local circuit cells, continue to be recruited in the EC during infancy and early childhood.

The centrosome is crucial for the microtubule dynamics that underlie the radial migration of developing rodent neurons but is not required for axon growth.

Preventing transient defects in postnatal cortical circuit function limits disease progression in a mouse model of Huntington disease.

Androgen signalling during development may represent the mechanism underpinning some observed sex-differences in adult human brain size.

Study demonstrates that the ion channel KCNN2 has an important role in motor skill learning deficiencies resulting from fetal alcohol exposure in mice.

Extopic expression of the XIST RNA at one chromosome 21 in iPSCs derived from individuals with Down syndrome leads to transcriptional silencing of chromosome 21 and improves iPSC differentiation into neurons.

RHOA drives the formation of actin arcs in neuronal growth cones in mice, limiting microtubule protrusion and restricting axon growth.