Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The neuromuscular junction is a specialized synapse between motor neurons and the muscle fibre they innervate. In vertebrates, the postsynaptic side is referred to as the endplate and contains a high-density of cholinergic receptors that facilitate synaptic transmission.
Mechanoneural interfaces combine surgically modified soft tissues and artificial components to enhance peripheral neural signalling for the reconstruction of bionic limbs. This Review discusses different mechanoneural interface architectures and presents preclinical and clinical evidence of their afferent and efferent properties.
Here, Urzi et al. pioneered a 2D self-organizing neuromuscular junction (soNMJ) model from human pluripotent stem cells, with implications for neuromuscular disease modeling and drug screening approaches.
New findings indicate a role for SMN protein in assembly of the synaptic SNARE complex at neuromuscular junctions, providing insight into mechanisms of pathology in spinal muscular atrophy.
Murine β-adducin, and its fly homologue HTS, have key roles in synapse assembly and disassembly, and mediate the improvement of learning and memory induced by environmental enrichment.
