• Article |

    Analyses of single-cell whole-genome sequencing data show that somatic mutations are increased in the brain of individuals with Alzheimer’s disease compared to neurotypical individuals, with a pattern of genomic damage distinct from that of normal ageing.

    • Michael B. Miller
    • , August Yue Huang
    •  & Christopher A. Walsh
  • Article |

    The authors report the structures of glutamate-gated kainate receptors in complex with NETO2 in both the resting and the desensitized states and reveal how kainate receptors in the brain are regulated by NETO2.

    • Lingli He
    • , Jiahui Sun
    •  & Yan Zhao
  • Article |

    Aggressive cerebral cavernous malformations (CCMs) are found to grow through a three-hit cancer-like mechanism, involving gain of function of a gene that promotes vascular growth, and loss of function of genes that suppress it.

    • Aileen A. Ren
    • , Daniel A. Snellings
    •  & Mark L. Kahn
  • Article |

    Experiments in mice show that a population of neurons in the vagal ganglia respond to the presence of glucose in the gut and connect to neurons in the brainstem, revealing the circuit that underlies the neural basis for the behavioural preference for sugar.

    • Hwei-Ee Tan
    • , Alexander C. Sisti
    •  & Charles S. Zuker
  • Article |

    Single-cell RNA sequencing of cells from humans with multiple sclerosis and mice with a model of the disease identifies a population of disease-promoting astrocytes in which anti-oxidant and anti-inflammatory proteins are suppressed.

    • Michael A. Wheeler
    • , Iain C. Clark
    •  & Francisco J. Quintana
  • Article |

    The lysosomal polyamine transporter ATP13A2 controls the cellular polyamine content, and impaired lysosomal polyamine export represents a lysosome-dependent cell death pathway that may be implicated in ATP13A2-associated neurodegeneration.

    • Sarah van Veen
    • , Shaun Martin
    •  & Peter Vangheluwe
  • Article |

    The authors show that NLRP3 inflammasome is activated in microglia of patients with fronto-temporal dementia and in a mouse model of tau pathology, and that the loss of NLRP3 inflammasome function decreases tau pathology and improves cognition in mice.

    • Christina Ising
    • , Carmen Venegas
    •  & Michael T. Heneka
  • Article |

    Activated clonally expanded CD4+ T cells display specificity to the myelin peptide MOG, whereas clonally expanded CD8+ T cells depend on T cell receptor recognition of unrelated surrogate peptides and have a regulatory function.

    • Naresha Saligrama
    • , Fan Zhao
    •  & Mark M. Davis
  • Letter |

    Single-nucleus RNA sequencing analysis identifies different subclusters of oligodendroglia in white matter from individuals with multiple sclerosis compared with controls, and these differences may be important for understanding disease progression.

    • Sarah Jäkel
    • , Eneritz Agirre
    •  & Gonçalo Castelo-Branco
  • Perspective |

    This Perspective discusses developments in LED-based solid-state lighting for physiological and agricultural applications, and the anticipated benefits in terms of health and productivity.

    • P. M. Pattison
    • , J. Y. Tsao
    •  & B. Bugbee
  • Letter |

    The structure of huntingtin in complex with an interactor is determined to an overall resolution of 4 Å, paving the way for improved understanding of the cellular functions of this protein.

    • Qiang Guo
    • , Bin Huang
    •  & Stefan Kochanek
  • Letter |

    Structural differences in 40- and 42-residue-long amyloid-β fibrils seeded in vitro from the cortical tissue of patients with different clinical subtypes of Alzheimer’s disease suggest that different fibril structures form in different disease variants and with different peptide lengths.

    • Wei Qiang
    • , Wai-Ming Yau
    •  & Robert Tycko
  • Brief Communications Arising |

    • John Collinge
    • , Zane Jaunmuktane
    •  & Sebastian Brandner
  • Article |

    Sustained delivery of axon-specific growth factors not typically present in spinal cord lesions allows for robust axonal regrowth only if the astrocytic scar is present—a result that questions the prevailing dogma and suggests that astrocytic scarring aids rather than prevents central nervous system axon regeneration post injury.

    • Mark A. Anderson
    • , Joshua E. Burda
    •  & Michael V. Sofroniew
  • Letter |

    Deep brain stimulation (DBS) of the fimbria–fornix—a region that provides input to the hippocampus—is shown to restore hippocampus-dependent memory and hippocampal long-term potentiation and neurogenesis in a mouse model of Rett syndrome, suggesting that DBS, which is already used in the treatment of several neurological conditions, could be a viable approach to mitigating cognitive impairment in Rett syndrome and other disorders of childhood intellectual disability.

    • Shuang Hao
    • , Bin Tang
    •  & Jianrong Tang