Neuroimmunology

Neuroimmunology is a field that studies the interaction of the immune and nervous systems.

Latest Research and Reviews

  • Research | | open

    Lymphangiogenesis occurs in the context of systemic inflammation and development but has not been reported for the lymphatics that surround the CNS. Here the authors show that in the context of experimental autoimmune encephatlitis, lymphangiogenesis occurs at the cribriform plate, but not the meninges, and contributes to immune cell and antigen drainage.

    • Martin Hsu
    • , Aditya Rayasam
    • , Julie A. Kijak
    • , Yun Hwa Choi
    • , Jeffrey S. Harding
    • , Sarah A. Marcus
    • , William J. Karpus
    • , Matyas Sandor
    •  & Zsuzsanna Fabry
  • Research | | open

    Chitinase 3-like-3 (Chi3l3) is expressed in microglia, but its function is not clear. Here the authors show that Chi3l3 is expressed in the subventricular zone in mouse experimental immune encephalitis, which induces oligodendrogenesis.

    • Sarah C. Starossom
    • , Juliana Campo Garcia
    • , Tim Woelfle
    • , Silvina Romero-Suarez
    • , Marta Olah
    • , Fumihiro Watanabe
    • , Li Cao
    • , Ada Yeste
    • , John J. Tukker
    • , Francisco J. Quintana
    • , Jaime Imitola
    • , Franziska Witzel
    • , Dietmar Schmitz
    • , Markus Morkel
    • , Friedemann Paul
    • , Carmen Infante-Duarte
    •  & Samia J. Khoury
  • Research |

    In a mouse model of ischaemic stroke, regulatory T cells infiltrate the injured brain in response to the chemokines CCL1 and CCL20 and suppress excessive astrogliosis via the production of amphiregulin.

    • Minako Ito
    • , Kyoko Komai
    • , Setsuko Mise-Omata
    • , Mana Iizuka-Koga
    • , Yoshiko Noguchi
    • , Taisuke Kondo
    • , Ryota Sakai
    • , Kazuhiko Matsuo
    • , Takashi Nakayama
    • , Osamu Yoshie
    • , Hiroko Nakatsukasa
    • , Shunsuke Chikuma
    • , Takashi Shichita
    •  & Akihiko Yoshimura
    Nature 565, 246-250
  • Research |

    Single-cell mass cytometry was applied to comprehensively characterize postmortem and fresh human microglia. Using a hybrid workflow for multidimensional data analysis, a core signature and regional heterogeneity were identified.

    • Chotima Böttcher
    • , Stephan Schlickeiser
    • , Marjolein A. M. Sneeboer
    • , Desiree Kunkel
    • , Anniki Knop
    • , Evdokia Paza
    • , Pawel Fidzinski
    • , Larissa Kraus
    • , Gijsje J. L. Snijders
    • , René S Kahn
    • , Axel R Schulz
    • , Henrik E Mei
    • , Elly M. Hol
    • , Britta Siegmund
    • , Rainer Glauben
    • , Eike J Spruth
    • , Lot D de Witte
    •  & Josef Priller
  • Research | | open

    Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcriptome and gene accessibility landscape.

    • Anat Shemer
    • , Jonathan Grozovski
    • , Tuan Leng Tay
    • , Jenhan Tao
    • , Alon Volaski
    • , Patrick Süß
    • , Alberto Ardura-Fabregat
    • , Mor Gross-Vered
    • , Jung-Seok Kim
    • , Eyal David
    • , Louise Chappell-Maor
    • , Lars Thielecke
    • , Christopher K. Glass
    • , Kerstin Cornils
    • , Marco Prinz
    •  & Steffen Jung

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