Neurodevelopmental disorders articles from across Nature Portfolio

In a large multinational cohort study, maternal, gestational or pregestational diabetes was associated with only a small-to-moderate risk of ADHD in offspring, contrary to previous estimates that showed stronger effect sizes, attributing the differences in findings to confounding by shared genetic and familial factors.

Understanding clinical heterogeneity in attention deficit hyperactivity disorder (ADHD) is important for improving personalized care and long-term outcomes. A study exploits the large scale and breadth of phenotyping of the iPSYCH cohort to link clinical heterogeneity to genetic heterogeneity in ADHD.

Repetitive DNA sequences known as tandem repeats (TRs) are linked to dozens of monogenic diseases and to cancer. We developed a computational method to characterize TRs using PacBio HiFi sequencing. This software can be used to discover and profile pathogenic repeat expansions and to catalog genetic and epigenetic variation in TR regions.