Neurodegenerative diseases

Neurodegenerative diseases are a heterogeneous group of disorders that are characterized by the progressive degeneration of the structure and function of the central nervous system or peripheral nervous system. Common neurodegenerative diseases include Alzheimer's disease and Parkinson's disease.

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Latest Research and Reviews

  • Research | | open

    There are currently no validated methods for the diagnosis of prion disease at the preclinical stage. Here the authors show that serial protein misfolding cyclic amplification and real-time quaking-induced conversion can be used to detect prions in the skin of prion-inoculated hamsters and humanized transgenic mice at early preclinical stages.

    • Zerui Wang
    • , Matteo Manca
    • , Aaron Foutz
    • , Manuel V. Camacho
    • , Gregory J. Raymond
    • , Brent Race
    • , Christina D. Orru
    • , Jue Yuan
    • , Pingping Shen
    • , Baiya Li
    • , Yue Lang
    • , Johnny Dang
    • , Alise Adornato
    • , Katie Williams
    • , Nicholas R. Maurer
    • , Pierluigi Gambetti
    • , Bin Xu
    • , Witold Surewicz
    • , Robert B. Petersen
    • , Xiaoping Dong
    • , Brian S. Appleby
    • , Byron Caughey
    • , Li Cui
    • , Qingzhong Kong
    •  & Wen-Quan Zou
  • Research |

    Neuroimaging and cerebrospinal fluid analyses in humans reveal that loss of blood–brain barrier integrity and brain capillary pericyte damage are early biomarkers of cognitive impairment that occur independently of changes in amyloid-β and tau.

    • Daniel A. Nation
    • , Melanie D. Sweeney
    • , Axel Montagne
    • , Abhay P. Sagare
    • , Lina M. D’Orazio
    • , Maricarmen Pachicano
    • , Farshid Sepehrband
    • , Amy R. Nelson
    • , David P. Buennagel
    • , Michael G. Harrington
    • , Tammie L. S. Benzinger
    • , Anne M. Fagan
    • , John M. Ringman
    • , Lon S. Schneider
    • , John C. Morris
    • , Helena C. Chui
    • , Meng Law
    • , Arthur W. Toga
    •  & Berislav V. Zlokovic
  • Research |

    Klim et al. illuminate pathomechanisms of ALS using pluripotent stem cells to identify transcripts altered in human motor neurons by perturbations to ALS protein TDP-43, finding the microtubule regulator STMN2 highly sensitive to TDP-43 malfunctions.

    • Joseph R. Klim
    • , Luis A. Williams
    • , Francesco Limone
    • , Irune Guerra San Juan
    • , Brandi N. Davis-Dusenbery
    • , Daniel A. Mordes
    • , Aaron Burberry
    • , Michael J. Steinbaugh
    • , Kanchana K. Gamage
    • , Rory Kirchner
    • , Rob Moccia
    • , Seth H. Cassel
    • , Kuchuan Chen
    • , Brian J. Wainger
    • , Clifford J. Woolf
    •  & Kevin Eggan
  • Research |

    The mRNA encoding stathmin-2, a protein implicated in axonal growth, is shown to be widely suppressed by premature polyadenylation in both sporadic and C9orf72 ALS through a mechanism directly dependent on loss of nuclear TDP-43 in motor neurons.

    • Ze’ev Melamed
    • , Jone López-Erauskin
    • , Michael W. Baughn
    • , Ouyang Zhang
    • , Kevin Drenner
    • , Ying Sun
    • , Fernande Freyermuth
    • , Moira A. McMahon
    • , Melinda S. Beccari
    • , Jon W. Artates
    • , Takuya Ohkubo
    • , Maria Rodriguez
    • , Nianwei Lin
    • , Dongmei Wu
    • , C. Frank Bennett
    • , Frank Rigo
    • , Sandrine Da Cruz
    • , John Ravits
    • , Clotilde Lagier-Tourenne
    •  & Don W. Cleveland

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