Neurochemistry articles from across Nature Portfolio

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ)-induced phosphorylation of the axon-stabilizing tau protein, which causes neurodegeneration. Here, Morshed et al. show that deregulated phosphorylation in AD also affects other proteins and cell types in the brain, suggesting that the tau-centric view on Aβ toxicity should be revised.

A new study reveals that a novel serotonin sensor in the spore-forming gut bacteria, Turicibacter sanguinis, might be important for host lipid and steroid metabolism. These findings support the emerging concept that bidirectional signalling pathways can influence bacterial community structure and exert effects on host physiology.

The external globus pallidus contains two populations of interconnected GABAergic neurons, one of which exclusively targets the striatum.