Neural tube defects articles within Nature Communications

Featured

• Article
  22 February 2024 | Open Access

  Noncanonical function of folate through folate receptor 1 during neural tube formation

  Neural tube defects are common birth defects that have been shown to be reduced through periconceptional folate supplementation, though the mechanism for this effect is unclear. Here they show that FOLR1 is necessary for neural tube formation in human neural organoids and Xenopus laevis embryos, and that this role is independent of its folate transport function.

  • Olga A. Balashova
  • , Alexios A. Panoutsopoulos
  •  & Laura N. Borodinsky

• Article
  26 July 2023 | Open Access

  A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development

  The molecular mechanisms ensuring early face, brain, and skin formation are unclear. Here, the authors uncover a posttranslational pathway that controls cytoskeletal signaling circuits to coordinate ectodermal patterning and neurulation.

  • Anthony J. Asmar
  • , Shaun R. Abrams
  •  & Achim Werner

• Article
  04 March 2015 | Open Access

  Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice

  Mutations in the enzyme glycine decarboxylase (GLDC) are associated with neural tube closure defects and non-ketotic hyperglycinemia in humans. Here the authors generate a mouse model with reduced Gldc expression and activity and study the direct effect of the enzyme in these diseases and the mechanisms responsible for neural tube closure defects.

  • Yun Jin Pai
  • , Kit-Yi Leung
  •  & Nicholas D.E. Greene

• Article | 24 March 2014

  EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1

  ADAM metalloproteases cleave ephrin signalling proteins and their receptors. Here, the authors show that ADAM10-mediated cleavage of ephrinB2 is inhibited by the lipid raft protein flotillin-1 and that ephrinB2 regulates apical constriction during neural tube closure in Xenopusembryos.

  • Yon Ju Ji
  • , Yoo-Seok Hwang
  •  & Ira O. Daar