Nephrons

The DNA damage response is essential to genomic stability. Here, the authors discuss DNA damage-induced nephrotoxicity and kidney cancer, and the essential role of DNA repair in kidney homeostasis, as well as its potential to contribute to kidney dysfunction, including the links between DNA damage, cell-cycle control and ciliopathies.

Any processes that impair kidney development in the developing fetus can have lifelong adverse consequences for renal health. Here, the authors discuss the effects of preterm birth and/or intrauterine growth restriction on kidney development and the impact of these exposures on the later development of chronic kidney disease.

In this Review, the authors discuss the mineral-related factors and kidney-derived molecules that regulate osteocyte FGF23 production in health and disease. They also highlight potential approaches to the treatment of FGF23-related disorders of mineral metabolism that target key bone–kidney interactions.