Nephrology

  • Article
    | Open Access

    Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network.

    • Ji Young Kim
    • , Yuntao Bai
    • , Laura A. Jayne
    • , Ralph D. Hector
    • , Avinash K. Persaud
    • , Su Sien Ong
    • , Shreshtha Rojesh
    • , Radhika Raj
    • , Mei Ji He Ho Feng
    • , Sangwoon Chung
    • , Rachel E. Cianciolo
    • , John W. Christman
    • , Moray J. Campbell
    • , David S. Gardner
    • , Sharyn D. Baker
    • , Alex Sparreboom
    • , Rajgopal Govindarajan
    • , Harpreet Singh
    • , Taosheng Chen
    • , Ming Poi
    • , Katalin Susztak
    • , Stuart R. Cobb
    •  & Navjot Singh Pabla
  • Article
    | Open Access

    Membranous nephropathy (MN) is a rare autoimmune disease of podocyte-directed antibodies, such as anti-phospholipase A2 receptor. Here, the authors report a genome-wide association study for MN and identify two previously unreported loci encompassing the NFKB1 and IRF4 genes and additional ancestry-specific effects.

    • Jingyuan Xie
    • , Lili Liu
    • , Nikol Mladkova
    • , Yifu Li
    • , Hong Ren
    • , Weiming Wang
    • , Zhao Cui
    • , Li Lin
    • , Xiaofan Hu
    • , Xialian Yu
    • , Jing Xu
    • , Gang Liu
    • , Yasar Caliskan
    • , Carlo Sidore
    • , Olivia Balderes
    • , Raphael J. Rosen
    • , Monica Bodria
    • , Francesca Zanoni
    • , Jun Y. Zhang
    • , Priya Krithivasan
    • , Karla Mehl
    • , Maddalena Marasa
    • , Atlas Khan
    • , Fatih Ozay
    • , Pietro A. Canetta
    • , Andrew S. Bomback
    • , Gerald B. Appel
    • , Simone Sanna-Cherchi
    • , Matthew G. Sampson
    • , Laura H. Mariani
    • , Agnieszka Perkowska-Ptasinska
    • , Magdalena Durlik
    • , Krzysztof Mucha
    • , Barbara Moszczuk
    • , Bartosz Foroncewicz
    • , Leszek Pączek
    • , Ireneusz Habura
    • , Elisabet Ars
    • , Jose Ballarin
    • , Laila-Yasmin Mani
    • , Bruno Vogt
    • , Savas Ozturk
    • , Abdülmecit Yildiz
    • , Nurhan Seyahi
    • , Hakki Arikan
    • , Mehmet Koc
    • , Taner Basturk
    • , Gonca Karahan
    • , Sebahat Usta Akgul
    • , Mehmet Sukru Sever
    • , Dan Zhang
    • , Domenico Santoro
    • , Mario Bonomini
    • , Francesco Londrino
    • , Loreto Gesualdo
    • , Jana Reiterova
    • , Vladimir Tesar
    • , Claudia Izzi
    • , Silvana Savoldi
    • , Donatella Spotti
    • , Carmelita Marcantoni
    • , Piergiorgio Messa
    • , Marco Galliani
    • , Dario Roccatello
    • , Simona Granata
    • , Gianluigi Zaza
    • , Francesca Lugani
    • , GianMarco Ghiggeri
    • , Isabella Pisani
    • , Landino Allegri
    • , Ben Sprangers
    • , Jin-Ho Park
    • , BeLong Cho
    • , Yon Su Kim
    • , Dong Ki Kim
    • , Hitoshi Suzuki
    • , Antonio Amoroso
    • , Daniel C. Cattran
    • , Fernando C. Fervenza
    • , Antonello Pani
    • , Patrick Hamilton
    • , Shelly Harris
    • , Sanjana Gupta
    • , Chris Cheshire
    • , Stephanie Dufek
    • , Naomi Issler
    • , Ruth J. Pepper
    • , John Connolly
    • , Stephen Powis
    • , Detlef Bockenhauer
    • , Horia C. Stanescu
    • , Neil Ashman
    • , Ruth J. F. Loos
    • , Eimear E. Kenny
    • , Matthias Wuttke
    • , Kai-Uwe Eckardt
    • , Anna Köttgen
    • , Julia M. Hofstra
    • , Marieke J. H. Coenen
    • , Lambertus A. Kiemeney
    • , Shreeram Akilesh
    • , Matthias Kretzler
    • , Lawrence H. Beck
    • , Benedicte Stengel
    • , Hanna Debiec
    • , Pierre Ronco
    • , Jack F. M. Wetzels
    • , Magdalena Zoledziewska
    • , Francesco Cucca
    • , Iuliana Ionita-Laza
    • , Hajeong Lee
    • , Elion Hoxha
    • , Rolf A. K. Stahl
    • , Paul Brenchley
    • , Francesco Scolari
    • , Ming-hui Zhao
    • , Ali G. Gharavi
    • , Robert Kleta
    • , Nan Chen
    •  & Krzysztof Kiryluk
  • Article
    | Open Access

    Methylmalonic acidemia is an inherited metabolic disease caused by loss or mutation of the enzyme MMUT. Here the authors use cell and animal models to show that MMUT mutations lead to defective mitophagy and stress in kidney cells, contributing to the pathogenesis in methylmalonic acidemia patients.

    • Alessandro Luciani
    • , Anke Schumann
    • , Marine Berquez
    • , Zhiyong Chen
    • , Daniela Nieri
    • , Mario Failli
    • , Huguette Debaix
    • , Beatrice Paola Festa
    • , Natsuko Tokonami
    • , Andrea Raimondi
    • , Alessio Cremonesi
    • , Diego Carrella
    • , Patrick Forny
    • , Stefan Kölker
    • , Francesca Diomedi Camassei
    • , Francisca Diaz
    • , Carlos T. Moraes
    • , Diego Di Bernardo
    • , Matthias R. Baumgartner
    •  & Olivier Devuyst
  • Article
    | Open Access

    Urinary tract infections (UTIs) are associated with changes in the gut microbiome. Here, the authors evaluate the relationship between the gut microbiome and development of UTI in kidney transplant patients and show that uropathogenic gut abundance might represent a risk factor for development of bacteriuria and UTI.

    • Matthew Magruder
    • , Adam N. Sholi
    • , Catherine Gong
    • , Lisa Zhang
    • , Emmanuel Edusei
    • , Jennifer Huang
    • , Shady Albakry
    • , Michael J. Satlin
    • , Lars F. Westblade
    • , Carl Crawford
    • , Darshana M. Dadhania
    • , Michelle Lubetzky
    • , Ying Taur
    • , Eric Littman
    • , Lilan Ling
    • , Philip Burnham
    • , Iwijn De Vlaminck
    • , Eric Pamer
    • , Manikkam Suthanthiran
    •  & John Richard Lee
  • Article
    | Open Access

    How reproducible human kidney organoids derived from different iPSC lines are, and how faithful they are to human kidney tissue remain unclear. Here, the authors use four human iPSC lines to derive kidney organoids and show how organoid composition is reproducible, comparable to human tissue and of improved quality after transplantation.

    • Ayshwarya Subramanian
    • , Eriene-Heidi Sidhom
    • , Maheswarareddy Emani
    • , Katherine Vernon
    • , Nareh Sahakian
    • , Yiming Zhou
    • , Maria Kost-Alimova
    • , Michal Slyper
    • , Julia Waldman
    • , Danielle Dionne
    • , Lan T. Nguyen
    • , Astrid Weins
    • , Jamie L. Marshall
    • , Orit Rosenblatt-Rosen
    • , Aviv Regev
    •  & Anna Greka
  • Article
    | Open Access

    Kidney stones form in the presence of overabundance of crystal-forming substances such as Ca2+ and oxalate. Here, the authors report genome-wide association analyses for kidney stone disease, report seven previously unknown loci and find that some of these loci also associate with Ca2+ concentration and excretion.

    • Sarah A. Howles
    • , Akira Wiberg
    • , Michelle Goldsworthy
    • , Asha L. Bayliss
    • , Anna K. Gluck
    • , Michael Ng
    • , Emily Grout
    • , Chizu Tanikawa
    • , Yoichiro Kamatani
    • , Chikashi Terao
    • , Atsushi Takahashi
    • , Michiaki Kubo
    • , Koichi Matsuda
    • , Rajesh V. Thakker
    • , Benjamin W. Turney
    •  & Dominic Furniss
  • Article
    | Open Access

    The use of immune checkpoint inhibitors (ICI) in cancer patients with solid organ allografts is hampered due to potential organ rejection. Here, the authors present a case report of a patient with kidney allograft and show that treatment with the mTOR inhibitor sirolimus preserves peripheral tolerance and anti-tumour efficacy of ICI therapy.

    • Khashayar Esfahani
    • , Tho-Alfakar Al-Aubodah
    • , Pamela Thebault
    • , Réjean Lapointe
    • , Marie Hudson
    • , Nathalie A. Johnson
    • , Dana Baran
    • , Najwa Bhulaiga
    • , Tomoko Takano
    • , Jean-François Cailhier
    • , Ciriaco A. Piccirillo
    •  & Wilson H. Miller
  • Article
    | Open Access

    Arctigenin (ATG) is the major active component of a Chinese herbal remedy known to reduce proteinuria in patients with diabetic kidney disease (DKD). Here, Zhong et al. identify PP2A as a pharmacological target of ATG in podocytes, and find that PP2A is responsible for some of the beneficial effects of ATG in mouse models of DKD.

    • Yifei Zhong
    • , Kyung Lee
    • , Yueyi Deng
    • , Yueming Ma
    • , Yiping Chen
    • , Xueling Li
    • , Chengguo Wei
    • , Shumin Yang
    • , Tianming Wang
    • , Nicholas J. Wong
    • , Alecia N. Muwonge
    • , Evren U. Azeloglu
    • , Weijia Zhang
    • , Bhaskar Das
    • , John Cijiang He
    •  & Ruijie Liu
  • Article
    | Open Access

    Autosomal dominant polycystic kidney disease (ADPKD) is a leading genetic cause of end-stage renal disease with limited treatment options. Here the authors discover and characterize a microRNA inhibitor as a potential treatment for ADPKD.

    • Edmund C. Lee
    • , Tania Valencia
    • , Charles Allerson
    • , Annelie Schairer
    • , Andrea Flaten
    • , Matanel Yheskel
    • , Kara Kersjes
    • , Jian Li
    • , Sole Gatto
    • , Mandeep Takhar
    • , Steven Lockton
    • , Adam Pavlicek
    • , Michael Kim
    • , Tiffany Chu
    • , Randy Soriano
    • , Scott Davis
    • , John R. Androsavich
    • , Salma Sarwary
    • , Tate Owen
    • , Julia Kaplan
    • , Kai Liu
    • , Graham Jang
    • , Steven Neben
    • , Philip Bentley
    • , Timothy Wright
    •  & Vishal Patel
  • Article
    | Open Access

    Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

    • Alexander Teumer
    • , Yong Li
    • , Sahar Ghasemi
    • , Bram P. Prins
    • , Matthias Wuttke
    • , Tobias Hermle
    • , Ayush Giri
    • , Karsten B. Sieber
    • , Chengxiang Qiu
    • , Holger Kirsten
    • , Adrienne Tin
    • , Audrey Y. Chu
    • , Nisha Bansal
    • , Mary F. Feitosa
    • , Lihua Wang
    • , Jin-Fang Chai
    • , Massimiliano Cocca
    • , Christian Fuchsberger
    • , Mathias Gorski
    • , Anselm Hoppmann
    • , Katrin Horn
    • , Man Li
    • , Jonathan Marten
    • , Damia Noce
    • , Teresa Nutile
    • , Sanaz Sedaghat
    • , Gardar Sveinbjornsson
    • , Bamidele O. Tayo
    • , Peter J. van der Most
    • , Yizhe Xu
    • , Zhi Yu
    • , Lea Gerstner
    • , Johan Ärnlöv
    • , Stephan J. L. Bakker
    • , Daniela Baptista
    • , Mary L. Biggs
    • , Eric Boerwinkle
    • , Hermann Brenner
    • , Ralph Burkhardt
    • , Robert J. Carroll
    • , Miao-Li Chee
    • , Miao-Ling Chee
    • , Mengmeng Chen
    • , Ching-Yu Cheng
    • , James P. Cook
    • , Josef Coresh
    • , Tanguy Corre
    • , John Danesh
    • , Martin H. de Borst
    • , Alessandro De Grandi
    • , Renée de Mutsert
    • , Aiko P. J. de Vries
    • , Frauke Degenhardt
    • , Katalin Dittrich
    • , Jasmin Divers
    • , Kai-Uwe Eckardt
    • , Georg Ehret
    • , Karlhans Endlich
    • , Janine F. Felix
    • , Oscar H. Franco
    • , Andre Franke
    • , Barry I. Freedman
    • , Sandra Freitag-Wolf
    • , Ron T. Gansevoort
    • , Vilmantas Giedraitis
    • , Martin Gögele
    • , Franziska Grundner-Culemann
    • , Daniel F. Gudbjartsson
    • , Vilmundur Gudnason
    • , Pavel Hamet
    • , Tamara B. Harris
    • , Andrew A. Hicks
    • , Hilma Holm
    • , Valencia Hui Xian Foo
    • , Shih-Jen Hwang
    • , M. Arfan Ikram
    • , Erik Ingelsson
    • , Vincent W. V. Jaddoe
    • , Johanna Jakobsdottir
    • , Navya Shilpa Josyula
    • , Bettina Jung
    • , Mika Kähönen
    • , Chiea-Chuen Khor
    • , Wieland Kiess
    • , Wolfgang Koenig
    • , Antje Körner
    • , Peter Kovacs
    • , Holly Kramer
    • , Bernhard K. Krämer
    • , Florian Kronenberg
    • , Leslie A. Lange
    • , Carl D. Langefeld
    • , Jeannette Jen-Mai Lee
    • , Terho Lehtimäki
    • , Wolfgang Lieb
    • , Su-Chi Lim
    • , Lars Lind
    • , Cecilia M. Lindgren
    • , Jianjun Liu
    • , Markus Loeffler
    • , Leo-Pekka Lyytikäinen
    • , Anubha Mahajan
    • , Joseph C. Maranville
    • , Deborah Mascalzoni
    • , Barbara McMullen
    • , Christa Meisinger
    • , Thomas Meitinger
    • , Kozeta Miliku
    • , Dennis O. Mook-Kanamori
    • , Martina Müller-Nurasyid
    • , Josyf C. Mychaleckyj
    • , Matthias Nauck
    • , Kjell Nikus
    • , Boting Ning
    • , Raymond Noordam
    • , Jeffrey O’ Connell
    • , Isleifur Olafsson
    • , Nicholette D. Palmer
    • , Annette Peters
    • , Anna I. Podgornaia
    • , Belen Ponte
    • , Tanja Poulain
    • , Peter P. Pramstaller
    • , Ton J. Rabelink
    • , Laura M. Raffield
    • , Dermot F. Reilly
    • , Rainer Rettig
    • , Myriam Rheinberger
    • , Kenneth M. Rice
    • , Fernando Rivadeneira
    • , Heiko Runz
    • , Kathleen A. Ryan
    • , Charumathi Sabanayagam
    • , Kai-Uwe Saum
    • , Ben Schöttker
    • , Christian M. Shaffer
    • , Yuan Shi
    • , Albert V. Smith
    • , Konstantin Strauch
    • , Michael Stumvoll
    • , Benjamin B. Sun
    • , Silke Szymczak
    • , E-Shyong Tai
    • , Nicholas Y. Q. Tan
    • , Kent D. Taylor
    • , Andrej Teren
    • , Yih-Chung Tham
    • , Joachim Thiery
    • , Chris H. L. Thio
    • , Hauke Thomsen
    • , Unnur Thorsteinsdottir
    • , Anke Tönjes
    • , Johanne Tremblay
    • , André G. Uitterlinden
    • , Pim van der Harst
    • , Niek Verweij
    • , Suzanne Vogelezang
    • , Uwe Völker
    • , Melanie Waldenberger
    • , Chaolong Wang
    • , Otis D. Wilson
    • , Charlene Wong
    • , Tien-Yin Wong
    • , Qiong Yang
    • , Masayuki Yasuda
    • , Shreeram Akilesh
    • , Murielle Bochud
    • , Carsten A. Böger
    • , Olivier Devuyst
    • , Todd L. Edwards
    • , Kevin Ho
    • , Andrew P. Morris
    • , Afshin Parsa
    • , Sarah A. Pendergrass
    • , Bruce M. Psaty
    • , Jerome I. Rotter
    • , Kari Stefansson
    • , James G. Wilson
    • , Katalin Susztak
    • , Harold Snieder
    • , Iris M. Heid
    • , Markus Scholz
    • , Adam S. Butterworth
    • , Adriana M. Hung
    • , Cristian Pattaro
    •  & Anna Köttgen
  • Article
    | Open Access

    Persistently low levels of estimated glomerular filtration rate (eGFR) are a biomarker of chronic kidney disease. Here, the authors reinterpret the genetic architecture of kidney function across ancestries, to identify not only genes, but the tissue and anatomical contexts of renal homeostasis.

    • Jacklyn N. Hellwege
    • , Digna R. Velez Edwards
    • , Ayush Giri
    • , Chengxiang Qiu
    • , Jihwan Park
    • , Eric S. Torstenson
    • , Jacob M. Keaton
    • , O. D. Wilson
    • , Cassianne Robinson-Cohen
    • , Cecilia P. Chung
    • , Christianne L. Roumie
    • , Derek Klarin
    • , Scott M. Damrauer
    • , Scott L. DuVall
    • , Edward Siew
    • , Elvis A. Akwo
    • , Matthias Wuttke
    • , Mathias Gorski
    • , Man Li
    • , Yong Li
    • , J. Michael Gaziano
    • , Peter W. F. Wilson
    • , Philip S. Tsao
    • , Christopher J. O’Donnell
    • , Csaba P. Kovesdy
    • , Cristian Pattaro
    • , Anna Köttgen
    • , Katalin Susztak
    • , Todd L. Edwards
    •  & Adriana M. Hung
  • Article
    | Open Access

    Levels of sodium and potassium in urine are associated with cardiovascular traits. Here, Pazoki et al. perform genome-wide association studies for urinary sodium and potassium secretion and identify 50 and 13 novel loci, respectively, some of which show a potential causal relationship with blood pressure based on MR analysis.

    • Raha Pazoki
    • , Evangelos Evangelou
    • , David Mosen-Ansorena
    • , Rui Climaco Pinto
    • , Ibrahim Karaman
    • , Paul Blakeley
    • , Dipender Gill
    • , Verena Zuber
    • , Paul Elliott
    • , Ioanna Tzoulaki
    •  & Abbas Dehghan
  • Article
    | Open Access

    Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.

    • Joshua D. Ooi
    • , Jhih-Hang Jiang
    • , Peter J. Eggenhuizen
    • , Ling L. Chua
    • , Mirjan van Timmeren
    • , Khai L. Loh
    • , Kim M. O’Sullivan
    • , Poh Y. Gan
    • , Yong Zhong
    • , Kirill Tsyganov
    • , Lani R. Shochet
    • , Jessica Ryan
    • , Coen A. Stegeman
    • , Lars Fugger
    • , Hugh H. Reid
    • , Jamie Rossjohn
    • , Peter Heeringa
    • , Stephen R. Holdsworth
    • , Anton Y. Peleg
    •  & A. Richard Kitching
  • Article
    | Open Access

    In both focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN), kidney injury is characterised by the invasion of glomerular tufts by parietal epithelial cells (PECs). Here Lazareth et al. identify the tetraspanin CD9 as a key regulator of PEC migration, and find its upregulation in FSGS and CGN contributes to kidney injury in both diseases.

    • Hélène Lazareth
    • , Carole Henique
    • , Olivia Lenoir
    • , Victor G. Puelles
    • , Martin Flamant
    • , Guillaume Bollée
    • , Cécile Fligny
    • , Marine Camus
    • , Lea Guyonnet
    • , Corinne Millien
    • , François Gaillard
    • , Anna Chipont
    • , Blaise Robin
    • , Sylvie Fabrega
    • , Neeraj Dhaun
    • , Eric Camerer
    • , Oliver Kretz
    • , Florian Grahammer
    • , Fabian Braun
    • , Tobias B. Huber
    • , Dominique Nochy
    • , Chantal Mandet
    • , Patrick Bruneval
    • , Laurent Mesnard
    • , Eric Thervet
    • , Alexandre Karras
    • , François Le Naour
    • , Eric Rubinstein
    • , Claude Boucheix
    • , Antigoni Alexandrou
    • , Marcus J. Moeller
    • , Cédric Bouzigues
    •  & Pierre-Louis Tharaux
  • Article
    | Open Access

    Single-cell studies in solid tissues remain challenging and have benefited from the development of single-nuclei RNA sequencing strategies. Here Lake et al. apply single-nucleus RNA sequencing to human kidney tissues to provide a comprehensive molecular and cellular atlas of the human kidney, with potential implications for the understanding of kidney physiology and disease.

    • Blue B. Lake
    • , Song Chen
    • , Masato Hoshi
    • , Nongluk Plongthongkum
    • , Diane Salamon
    • , Amanda Knoten
    • , Anitha Vijayan
    • , Ramakrishna Venkatesh
    • , Eric H. Kim
    • , Derek Gao
    • , Joseph Gaut
    • , Kun Zhang
    •  & Sanjay Jain
  • Article
    | Open Access

    Patients with diabetes commonly develop diabetic kidney disease (DKD). Here Gluck et al. identify a set of probes differentially methylated in renal samples from patients with DKD, and find that inclusion of these methylation probes improves current prediction models of renal function decline.

    • Caroline Gluck
    • , Chengxiang Qiu
    • , Sang Youb Han
    • , Matthew Palmer
    • , Jihwan Park
    • , Yi-An Ko
    • , Yuting Guan
    • , Xin Sheng
    • , Robert L. Hanson
    • , Jing Huang
    • , Yong Chen
    • , Ae Seo Deok Park
    • , Maria Concepcion Izquierdo
    • , Ioannis Mantzaris
    • , Amit Verma
    • , James Pullman
    • , Hongzhe Li
    •  & Katalin Susztak
  • Article
    | Open Access

    Angiotensin II is known to cause renal inflammation and fibrosis. Here Lu et al. show that levels of circulating miR-103a-3p are elevated in hypertensive nephropathy patients and in an animal model of angiotensin II-induced renal dysfunction, and that miR-103a-3p suppresses SNRK expression leading to the activation of the pro-inflammatory NF-κB pathway in glomerular endothelial cells.

    • Qiulun Lu
    • , Zejun Ma
    • , Ye Ding
    • , Tatiana Bedarida
    • , Liming Chen
    • , Zhonglin Xie
    • , Ping Song
    •  & Ming-Hui Zou
  • Article
    | Open Access

    Kinase inhibitors used in chemotherapy are known for their adverse effects on kidney physiology. Here, Calizo et al. show that dasatinib is associated with a higher risk of glomerular toxicity compared to other kinase inhibitors, due to deleterious effects on cytoskeletal biomechanics in podocytes.

    • Rhodora C. Calizo
    • , Smiti Bhattacharya
    • , J. G. Coen van Hasselt
    • , Chengguo Wei
    • , Jenny S. Wong
    • , Robert J. Wiener
    • , Xuhua Ge
    • , Nicholas J. Wong
    • , Jia-Jye Lee
    • , Christina M. Cuttitta
    • , Gomathi Jayaraman
    • , Vivienne H. Au
    • , William Janssen
    • , Tong Liu
    • , Hong Li
    • , Fadi Salem
    • , Edgar A. Jaimes
    • , Barbara Murphy
    • , Kirk N. Campbell
    •  & Evren U. Azeloglu
  • Article
    | Open Access

    Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that deletion of TMEM33 protects mice from acute kidney injury.

    • Malika Arhatte
    • , Gihan S. Gunaratne
    • , Charbel El Boustany
    • , Ivana Y. Kuo
    • , Céline Moro
    • , Fabrice Duprat
    • , Magali Plaisant
    • , Hélène Duval
    • , Dahui Li
    • , Nicolas Picard
    • , Anais Couvreux
    • , Christophe Duranton
    • , Isabelle Rubera
    • , Sophie Pagnotta
    • , Sandra Lacas-Gervais
    • , Barbara E. Ehrlich
    • , Jonathan S. Marchant
    • , Aaron M. Savage
    • , Fredericus J. M. van Eeden
    • , Robert N. Wilkinson
    • , Sophie Demolombe
    • , Eric Honoré
    •  & Amanda Patel
  • Article
    | Open Access

    Estimated glomerular filtration rate (eGFR) is a measure of kidney function and used to characterize chronic kidney disease. Here, Graham et al. identify 53 novel loci for eGFR in a GWAS meta-analysis, a subset of which are associated with other common diseases, such as diabetes and hypertension, based on PheWAS.

    • Sarah E. Graham
    • , Jonas B. Nielsen
    • , Matthew Zawistowski
    • , Wei Zhou
    • , Lars G. Fritsche
    • , Maiken E. Gabrielsen
    • , Anne Heidi Skogholt
    • , Ida Surakka
    • , Whitney E. Hornsby
    • , Damian Fermin
    • , Daniel B. Larach
    • , Sachin Kheterpal
    • , Chad M. Brummett
    • , Seunggeun Lee
    • , Hyun Min Kang
    • , Goncalo R. Abecasis
    • , Solfrid Romundstad
    • , Stein Hallan
    • , Matthew G. Sampson
    • , Kristian Hveem
    •  & Cristen J. Willer
  • Article
    | Open Access

    Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease.

    • Koichi Kikuchi
    • , Daisuke Saigusa
    • , Yoshitomi Kanemitsu
    • , Yotaro Matsumoto
    • , Paxton Thanai
    • , Naoto Suzuki
    • , Koki Mise
    • , Hiroaki Yamaguchi
    • , Tomohiro Nakamura
    • , Kei Asaji
    • , Chikahisa Mukawa
    • , Hiroki Tsukamoto
    • , Toshihiro Sato
    • , Yoshitsugu Oikawa
    • , Tomoyuki Iwasaki
    • , Yuji Oe
    • , Tomoya Tsukimi
    • , Noriko N. Fukuda
    • , Hsin-Jung HO
    • , Fumika Nanto-Hara
    • , Jiro Ogura
    • , Ritsumi Saito
    • , Shizuko Nagao
    • , Yusuke Ohsaki
    • , Satoshi Shimada
    • , Takehiro Suzuki
    • , Takafumi Toyohara
    • , Eikan Mishima
    • , Hisato Shima
    • , Yasutoshi Akiyama
    • , Yukako Akiyama
    • , Mariko Ichijo
    • , Tetsuro Matsuhashi
    • , Akihiro Matsuo
    • , Yoshiaki Ogata
    • , Ching-Chin Yang
    • , Chitose Suzuki
    • , Matthew C. Breeggemann
    • , Jurgen Heymann
    • , Miho Shimizu
    • , Susumu Ogawa
    • , Nobuyuki Takahashi
    • , Takashi Suzuki
    • , Yuji Owada
    • , Shigeo Kure
    • , Nariyasu Mano
    • , Tomoyoshi Soga
    • , Takashi Wada
    • , Jeffrey B. Kopp
    • , Shinji Fukuda
    • , Atsushi Hozawa
    • , Masayuki Yamamoto
    • , Sadayoshi Ito
    • , Jun Wada
    • , Yoshihisa Tomioka
    •  & Takaaki Abe
  • Article
    | Open Access

    Accurate monitoring of chronic kidney disease (CKD) progression is essential for efficient disease management. Here Chen et al. identify five serum metabolites in patients with stage 1–5 CKD whose levels associate with disease progression, and find that 5-methoxytryptophan and its regulatory enzyme TPH-1 exert anti-fibrotic effects in mouse models of kidney injury.

    • Dan-Qian Chen
    • , Gang Cao
    • , Hua Chen
    • , Christos P. Argyopoulos
    • , Hui Yu
    • , Wei Su
    • , Lin Chen
    • , David C. Samuels
    • , Shougang Zhuang
    • , George P. Bayliss
    • , Shilin Zhao
    • , Xiao-Yong Yu
    • , Nosratola D. Vaziri
    • , Ming Wang
    • , Dan Liu
    • , Jia-Rong Mao
    • , Shi-Xing Ma
    • , Jin Zhao
    • , Yuan Zhang
    • , You-Quan Shang
    • , Huining Kang
    • , Fei Ye
    • , Xiao-Hong Cheng
    • , Xiang-Ri Li
    • , Li Zhang
    • , Mei-Xia Meng
    • , Yan Guo
    •  & Ying-Yong Zhao
  • Article
    | Open Access

    Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 signaling, thus relieving repression of the osteogenic regulator Runx2.

    • Cheng Wang
    • , Wenjing Xu
    • , Jie An
    • , Minglu Liang
    • , Yiqing Li
    • , Fengxiao Zhang
    • , Qiangsong Tong
    •  & Kai Huang
  • Article
    | Open Access

    Allograft can induces local chronic inflammation, but how this feeds back to regulating late immunity is still not clear. Here the authors show, by charactering B cell transcriptome landscape dynamic in human allografts and in mouse kidneys transitioning from acute to chronic injury, that late B cell activation is associated with renal dysfunction and inflammation.

    • Pietro E. Cippà
    • , Jing Liu
    • , Bo Sun
    • , Sanjeev Kumar
    • , Maarten Naesens
    •  & Andrew P. McMahon
  • Article
    | Open Access

    Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of function both during development and in maturity.

    • J. A. Hurcombe
    • , P. Hartley
    • , A. C. Lay
    • , L. Ni
    • , J. J. Bedford
    • , J. P. Leader
    • , S. Singh
    • , A. Murphy
    • , C. L. Scudamore
    • , E. Marquez
    • , A. F. Barrington
    • , V. Pinto
    • , M. Marchetti
    • , L.-F. Wong
    • , J. Uney
    • , M. A. Saleem
    • , P. W. Mathieson
    • , S. Patel
    • , R. J. Walker
    • , J. R. Woodgett
    • , S. E. Quaggin
    • , G. I. Welsh
    •  & R. J. M. Coward
  • Article
    | Open Access

    There are currently no effective therapies available for acute kidney injury (AKI). Here the authors generate molybdenum-based polyoxometalate nanoclusters and show that these have preferential renal uptake and can ameliorate AKI pathology in mice by scavenging reactive oxygen species.

    • Dalong Ni
    • , Dawei Jiang
    • , Christopher J. Kutyreff
    • , Jianhao Lai
    • , Yongjun Yan
    • , Todd E. Barnhart
    • , Bo Yu
    • , Hyung-Jun Im
    • , Lei Kang
    • , Steve Y. Cho
    • , Zhaofei Liu
    • , Peng Huang
    • , Jonathan W. Engle
    •  & Weibo Cai
  • Article
    | Open Access

    Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease causing mutations.

    • Casper Larsen
    • , Anders Etzerodt
    • , Mette Madsen
    • , Karsten Skjødt
    • , Søren Kragh Moestrup
    •  & Christian Brix Folsted Andersen
  • Article
    | Open Access

    The molecular mechanisms that underlie associations in GWAS, incl. chronic kidney disease (CKD), are largely unknown. Here, the authors perform an integrative analysis of genetic, transcriptomic and epigenomic data from human kidney to pinpoint plausible molecular pathways of CKD genetic associations.

    • Xiaoguang Xu
    • , James M. Eales
    • , Artur Akbarov
    • , Hui Guo
    • , Lorenz Becker
    • , David Talavera
    • , Fehzan Ashraf
    • , Jabran Nawaz
    • , Sanjeev Pramanik
    • , John Bowes
    • , Xiao Jiang
    • , John Dormer
    • , Matthew Denniff
    • , Andrzej Antczak
    • , Monika Szulinska
    • , Ingrid Wise
    • , Priscilla R. Prestes
    • , Maciej Glyda
    • , Pawel Bogdanski
    • , Ewa Zukowska-Szczechowska
    • , Carlo Berzuini
    • , Adrian S. Woolf
    • , Nilesh J. Samani
    • , Fadi J. Charchar
    •  & Maciej Tomaszewski
  • Article
    | Open Access

    Injuries in the embryonal kidney can be repaired by a cell migratory response but how this is regulated at a molecular level is unclear. Here, the authors show in mice that deletion of Cxcl12 and Myc delays pronephros injury repair by changing mitochondrial metabolism and glycolysis.

    • Toma A. Yakulov
    • , Abhijeet P. Todkar
    • , Krasimir Slanchev
    • , Johannes Wiegel
    • , Alexandra Bona
    • , Martin Groß
    • , Alexander Scholz
    • , Isabell Hess
    • , Anne Wurditsch
    • , Florian Grahammer
    • , Tobias B. Huber
    • , Virginie Lecaudey
    • , Tillmann Bork
    • , Jochen Hochrein
    • , Melanie Boerries
    • , Justine Leenders
    • , Pascal de Tullio
    • , François Jouret
    • , Albrecht Kramer-Zucker
    •  & Gerd Walz
  • Article
    | Open Access

    Suppression of gene expression due to aberrant promoter methylation contributes to organ fibrosis. Here, the authors couple a deactivated Cas9 to the TET3 catalytic domain to induce expression of four antifibrotic genes, and show that lentiviral-mediated delivery is effective in reducing kidney fibrosis in mouse models.

    • Xingbo Xu
    • , Xiaoying Tan
    • , Björn Tampe
    • , Tim Wilhelmi
    • , Melanie S. Hulshoff
    • , Shoji Saito
    • , Tobias Moser
    • , Raghu Kalluri
    • , Gerd Hasenfuss
    • , Elisabeth M. Zeisberg
    •  & Michael Zeisberg
  • Article
    | Open Access

    Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2.

    • Wang Zheng
    • , Xiaoyong Yang
    • , Ruikun Hu
    • , Ruiqi Cai
    • , Laura Hofmann
    • , Zhifei Wang
    • , Qiaolin Hu
    • , Xiong Liu
    • , David Bulkley
    • , Yong Yu
    • , Jingfeng Tang
    • , Veit Flockerzi
    • , Ying Cao
    • , Erhu Cao
    •  & Xing-Zhen Chen
  • Article
    | Open Access

    The recovery of function upon acute kidney injury is thought to involve tubular cell dedifferentiation and proliferation. Here the authors show that Pax2+ progenitors regenerate tubules via cell division while other tubular cells support function recovery by undergoing hypertrophy through endoreplication.

    • Elena Lazzeri
    • , Maria Lucia Angelotti
    • , Anna Peired
    • , Carolina Conte
    • , Julian A. Marschner
    • , Laura Maggi
    • , Benedetta Mazzinghi
    • , Duccio Lombardi
    • , Maria Elena Melica
    • , Sara Nardi
    • , Elisa Ronconi
    • , Alessandro Sisti
    • , Giulia Antonelli
    • , Francesca Becherucci
    • , Letizia De Chiara
    • , Ricardo Romero Guevara
    • , Alexa Burger
    • , Beat Schaefer
    • , Francesco Annunziato
    • , Hans-Joachim Anders
    • , Laura Lasagni
    •  & Paola Romagnani
  • Article
    | Open Access

    Intu is a planar cell polarity protein known to regulate ciliogenesis during embryonic development. Here, Wang et al. identify a role for Intu in adult kidneys, where they find it promotes degradation of STAT1 and thus prevents cilia loss and cell death upon ischemia-reperfusion injury.

    • Shixuan Wang
    • , Aimin Liu
    • , Guangyu Wu
    • , Han-Fei Ding
    • , Shuang Huang
    • , Stanley Nahman
    •  & Zheng Dong
  • Article
    | Open Access

    Polycystic kidney disease (PKD) is characterized by the formation of large fluid-filled cysts. Here Flowers and colleagues show that loss of Lkb1, downregulated in PKD, renders kidney cells dependent on glutamine for growth, and suggest that inhibition of glutamine metabolism may prevent cyst development in PKD.

    • Ebony M. Flowers
    • , Jessica Sudderth
    • , Lauren Zacharias
    • , Glenda Mernaugh
    • , Roy Zent
    • , Ralph J. DeBerardinis
    •  & Thomas J. Carroll
  • Article
    | Open Access

    Nephropathic cystinosis is a lysosomal storage disease characterized by proximal tubular cell dysfunction. Here Festa and colleagues show that these lysosomal alterations lead to defective autophagic clearance of mitochondria and increased oxidative stress that, in turn, activates the transcription factor ZONAB leading to impaired cell differentiation.

    • Beatrice Paola Festa
    • , Zhiyong Chen
    • , Marine Berquez
    • , Huguette Debaix
    • , Natsuko Tokonami
    • , Jenny Ann Prange
    • , Glenn van de Hoek
    • , Cremonesi Alessio
    • , Andrea Raimondi
    • , Nathalie Nevo
    • , Rachel H. Giles
    • , Olivier Devuyst
    •  & Alessandro Luciani
  • Article
    | Open Access

    Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and internalization of the ion channels, ORAI1-3.

    • Bo Zeng
    • , Gui-Lan Chen
    • , Eliana Garcia-Vaz
    • , Sunil Bhandari
    • , Nikoleta Daskoulidou
    • , Lisa M. Berglund
    • , Hongni Jiang
    • , Thomas Hallett
    • , Lu-Ping Zhou
    • , Li Huang
    • , Zi-Hao Xu
    • , Viji Nair
    • , Robert G. Nelson
    • , Wenjun Ju
    • , Matthias Kretzler
    • , Stephen L. Atkin
    • , Maria F. Gomez
    •  & Shang-Zhong Xu
  • Article
    | Open Access

    Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle.

    • Carole Henique
    • , Guillaume Bollée
    • , Xavier Loyer
    • , Florian Grahammer
    • , Neeraj Dhaun
    • , Marine Camus
    • , Julien Vernerey
    • , Léa Guyonnet
    • , François Gaillard
    • , Hélène Lazareth
    • , Charlotte Meyer
    • , Imane Bensaada
    • , Luc Legrès
    • , Takashi Satoh
    • , Shizuo Akira
    • , Patrick Bruneval
    • , Stefanie Dimmeler
    • , Alain Tedgui
    • , Alexandre Karras
    • , Eric Thervet
    • , Dominique Nochy
    • , Tobias B. Huber
    • , Laurent Mesnard
    • , Olivia Lenoir
    •  & Pierre-Louis Tharaux
  • Article
    | Open Access

    Progressive tubule cell damage results in defects in mitochondrial metabolism and exercise seems to be beneficial during chronic kidney disease. Here Peng et al. show that irisin, an exercise-induced myokine, improves kidney energy metabolism by inhibiting TGF-β type 1 receptors and ameliorates fibrosis.

    • Hui Peng
    • , Qianqian Wang
    • , Tanqi Lou
    • , Jun Qin
    • , Sungyun Jung
    • , Vivekananda Shetty
    • , Feng Li
    • , Yanlin Wang
    • , Xin-hua Feng
    • , William E. Mitch
    • , Brett H. Graham
    •  & Zhaoyong Hu
  • Article
    | Open Access

    Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells.

    • Ana Filipa Gonçalves
    • , Mojca Adlesic
    • , Simone Brandt
    • , Tomas Hejhal
    • , Sabine Harlander
    • , Lukas Sommer
    • , Olga Shakhova
    • , Peter J. Wild
    •  & Ian J. Frew
  • Article
    | Open Access

    Genome-wide association studies of kidney function show enrichment of associated genetic variants in regulatory regions. Here, the authors perform epigenome-wide association studies of kidney function and disease, identifying 19 CpG sites significantly associated with these.

    • Audrey Y. Chu
    • , Adrienne Tin
    • , Pascal Schlosser
    • , Yi-An Ko
    • , Chengxiang Qiu
    • , Chen Yao
    • , Roby Joehanes
    • , Morgan E. Grams
    • , Liming Liang
    • , Caroline A. Gluck
    • , Chunyu Liu
    • , Josef Coresh
    • , Shih-Jen Hwang
    • , Daniel Levy
    • , Eric Boerwinkle
    • , James S. Pankow
    • , Qiong Yang
    • , Myriam Fornage
    • , Caroline S. Fox
    • , Katalin Susztak
    •  & Anna Köttgen
  • Article
    | Open Access

    The formation mechanism of abundant calcium oxalate biomaterials is unresolved. Here the authors show the early stages of calcium oxalate formation in pure and citrate-bearing solutions by using a titration set-up in conjunction with solution quenching, transmission electron microscopy and analytical ultracentrifugation.

    • Encarnación Ruiz-Agudo
    • , Alejandro Burgos-Cara
    • , Cristina Ruiz-Agudo
    • , Aurelia Ibañez-Velasco
    • , Helmut Cölfen
    •  & Carlos Rodriguez-Navarro
  • Article
    | Open Access

    Podocytes are essential components of the renal glomerular filtration barrier and podocyte dysfunction leads to proteinuric kidney disease. Here Liu et al. show that Sirt6 protects podocytes from apoptosis and inflammation by increasing autophagic flux through inhibition of the Notch pathway.

    • Min Liu
    • , Kaili Liang
    • , Junhui Zhen
    • , Meng Zhou
    • , Xiaojie Wang
    • , Ziying Wang
    • , Xinbing Wei
    • , Yan Zhang
    • , Yu Sun
    • , Zhuanli Zhou
    • , Hua Su
    • , Chun Zhang
    • , Ningjun Li
    • , Chengjiang Gao
    • , Jun Peng
    •  & Fan Yi
  • Article
    | Open Access

    Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening genetic disease that leads to renal failure. Here Hajarniset al. show that miR-17 modulates cyst progression in ADPKD through metabolic reprogramming of mitochondria and its inhibition slows cyst development and improves renal functions.

    • Sachin Hajarnis
    • , Ronak Lakhia
    • , Matanel Yheskel
    • , Darren Williams
    • , Mehran Sorourian
    • , Xueqing Liu
    • , Karam Aboudehen
    • , Shanrong Zhang
    • , Kara Kersjes
    • , Ryan Galasso
    • , Jian Li
    • , Vivek Kaimal
    • , Steven Lockton
    • , Scott Davis
    • , Andrea Flaten
    • , Joshua A. Johnson
    • , William L. Holland
    • , Christine M. Kusminski
    • , Philipp E. Scherer
    • , Peter C. Harris
    • , Marie Trudel
    • , Darren P. Wallace
    • , Peter Igarashi
    • , Edmund C. Lee
    • , John R. Androsavich
    •  & Vishal Patel
  • Article
    | Open Access

    The polyol pathway, which converts glucose into sorbitol and fructose, is active in chronic conditions like hepatic steatosis and chronic kidney disease. Here, Andres-Hernandoet al. show that fructose production promotes renal injury and fructokinase inhibition protects against kidney damage during ischaemic acute kidney disease.

    • Ana Andres-Hernando
    • , Nanxing Li
    • , Christina Cicerchi
    • , Shinichiro Inaba
    • , Wei Chen
    • , Carlos Roncal-Jimenez
    • , Myphuong T. Le
    • , Michael F. Wempe
    • , Tamara Milagres
    • , Takuji Ishimoto
    • , Mehdi Fini
    • , Takahiko Nakagawa
    • , Richard J. Johnson
    •  & Miguel A. Lanaspa
  • Article
    | Open Access

    Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demonstrate therapeutic efficacy in iron overload mouse models.

    • Jonathan Barasch
    • , Maria Hollmen
    • , Rong Deng
    • , Eldad A. Hod
    • , Peter B. Rupert
    • , Rebecca J. Abergel
    • , Benjamin E. Allred
    • , Katherine Xu
    • , Shaun F. Darrah
    • , Yared Tekabe
    • , Alan Perlstein
    • , Rebecca Wax
    • , Efrat Bruck
    • , Jacob Stauber
    • , Kaitlyn A. Corbin
    • , Charles Buchen
    • , Vesna Slavkovich
    • , Joseph Graziano
    • , Steven L. Spitalnik
    • , Guanhu Bao
    • , Roland K. Strong
    •  & Andong Qiu
  • Article
    | Open Access

    Nephropathy is a common and hard-to-treat consequence of diabetes. Here Kato et al. show that a megacluster of microRNAs regulates early development of diabetic nephropathy in mice, and that inhibition of the cluster's host long non-coding RNA transcript attenuates disease symptoms, suggesting a new therapy for diabetic nephropathy.

    • Mitsuo Kato
    • , Mei Wang
    • , Zhuo Chen
    • , Kirti Bhatt
    • , Hyung Jung Oh
    • , Linda Lanting
    • , Supriya Deshpande
    • , Ye Jia
    • , Jennifer Y.C. Lai
    • , Christopher L. O’Connor
    • , YiFan Wu
    • , Jeffrey B. Hodgin
    • , Robert G. Nelson
    • , Markus Bitzer
    •  & Rama Natarajan
  • Article
    | Open Access

    In Drosophila, Fasciclin 2 (Fas2) has been mainly studied in the nervous system, yet this adhesion protein is more abundant in the adult renal tubule. Here the authors show that Fas2 is essential for brush border maintenance in renal tubules through regulation of microvilli length and organization.

    • Kenneth A. Halberg
    • , Stephanie M. Rainey
    • , Iben R. Veland
    • , Helen Neuert
    • , Anthony J. Dornan
    • , Christian Klämbt
    • , Shireen-Anne Davies
    •  & Julian A. T. Dow
  • Article
    | Open Access

    Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.

    • Cristian Pattaro
    • , Alexander Teumer
    • , Mathias Gorski
    • , Audrey Y. Chu
    • , Man Li
    • , Vladan Mijatovic
    • , Maija Garnaas
    • , Adrienne Tin
    • , Rossella Sorice
    • , Yong Li
    • , Daniel Taliun
    • , Matthias Olden
    • , Meredith Foster
    • , Qiong Yang
    • , Ming-Huei Chen
    • , Tune H. Pers
    • , Andrew D. Johnson
    • , Yi-An Ko
    • , Christian Fuchsberger
    • , Bamidele Tayo
    • , Michael Nalls
    • , Mary F. Feitosa
    • , Aaron Isaacs
    • , Abbas Dehghan
    • , Pio d’Adamo
    • , Adebowale Adeyemo
    • , Aida Karina Dieffenbach
    • , Alan B. Zonderman
    • , Ilja M. Nolte
    • , Peter J. van der Most
    • , Alan F. Wright
    • , Alan R. Shuldiner
    • , Alanna C. Morrison
    • , Albert Hofman
    • , Albert V. Smith
    • , Albert W. Dreisbach
    • , Andre Franke
    • , Andre G. Uitterlinden
    • , Andres Metspalu
    • , Anke Tonjes
    • , Antonio Lupo
    • , Antonietta Robino
    • , Åsa Johansson
    • , Ayse Demirkan
    • , Barbara Kollerits
    • , Barry I. Freedman
    • , Belen Ponte
    • , Ben A. Oostra
    • , Bernhard Paulweber
    • , Bernhard K. Krämer
    • , Braxton D. Mitchell
    • , Brendan M. Buckley
    • , Carmen A. Peralta
    • , Caroline Hayward
    • , Catherine Helmer
    • , Charles N. Rotimi
    • , Christian M. Shaffer
    • , Christian Müller
    • , Cinzia Sala
    • , Cornelia M. van Duijn
    • , Aude Saint-Pierre
    • , Daniel Ackermann
    • , Daniel Shriner
    • , Daniela Ruggiero
    • , Daniela Toniolo
    • , Yingchang Lu
    • , Daniele Cusi
    • , Darina Czamara
    • , David Ellinghaus
    • , David S. Siscovick
    • , Douglas Ruderfer
    • , Christian Gieger
    • , Harald Grallert
    • , Elena Rochtchina
    • , Elizabeth J. Atkinson
    • , Elizabeth G. Holliday
    • , Eric Boerwinkle
    • , Erika Salvi
    • , Erwin P. Bottinger
    • , Federico Murgia
    • , Fernando Rivadeneira
    • , Florian Ernst
    • , Florian Kronenberg
    • , Frank B. Hu
    • , Gerjan J. Navis
    • , Gary C. Curhan
    • , George B. Ehret
    • , Georg Homuth
    • , Stefan Coassin
    • , Gian-Andri Thun
    • , Giorgio Pistis
    • , Giovanni Gambaro
    • , Giovanni Malerba
    • , Grant W. Montgomery
    • , Gudny Eiriksdottir
    • , Gunnar Jacobs
    • , Guo Li
    • , H-Erich Wichmann
    • , Harry Campbell
    • , Helena Schmidt
    • , Henri Wallaschofski
    • , Henry Völzke
    • , Hermann Brenner
    • , Heyo K. Kroemer
    • , Holly Kramer
    • , Honghuang Lin
    • , I. Mateo Leach
    • , Ian Ford
    • , Idris Guessous
    • , Igor Rudan
    • , Inga Prokopenko
    • , Ingrid Borecki
    • , Iris M. Heid
    • , Ivana Kolcic
    • , Ivana Persico
    • , J. Wouter Jukema
    • , James F. Wilson
    • , Janine F. Felix
    • , Jasmin Divers
    • , Jean-Charles Lambert
    • , Jeanette M. Stafford
    • , Jean-Michel Gaspoz
    • , Jennifer A. Smith
    • , Jessica D. Faul
    • , Jie Jin Wang
    • , Jingzhong Ding
    • , Joel N. Hirschhorn
    • , John Attia
    • , John B. Whitfield
    • , John Chalmers
    • , Jorma Viikari
    • , Josef Coresh
    • , Joshua C. Denny
    • , Juha Karjalainen
    • , Jyotika K. Fernandes
    • , Karlhans Endlich
    • , Katja Butterbach
    • , Keith L. Keene
    • , Kurt Lohman
    • , Laura Portas
    • , Lenore J. Launer
    • , Leo-Pekka Lyytikäinen
    • , Loic Yengo
    • , Lude Franke
    • , Luigi Ferrucci
    • , Lynda M. Rose
    • , Lyudmyla Kedenko
    • , Madhumathi Rao
    • , Maksim Struchalin
    • , Marcus E. Kleber
    • , Margherita Cavalieri
    • , Margot Haun
    • , Marilyn C. Cornelis
    • , Marina Ciullo
    • , Mario Pirastu
    • , Mariza de Andrade
    • , Mark A. McEvoy
    • , Mark Woodward
    • , Martin Adam
    • , Massimiliano Cocca
    • , Matthias Nauck
    • , Medea Imboden
    • , Melanie Waldenberger
    • , Menno Pruijm
    • , Marie Metzger
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  • Article
    | Open Access

    The growth factors BMP and FGF both stimulate the self-renewal of nephron progenitor cells (NPCs), but how these signals overlap is unclear. Here in the mouse, Muthukrishnan et al. find BMP7 and FGF9 coordinately regulate AP-1 transcriptional activity, promoting G1-S cell cycle progression and NPC proliferation.

    • Sree Deepthi Muthukrishnan
    • , Xuehui Yang
    • , Robert Friesel
    •  & Leif Oxburgh