Neonatal sepsis articles within Nature Communications

Featured

• Article
  23 January 2024 | Open Access

  An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life

  Neutrophils play critical roles in response to infection, and the limit of available neutrophils in neonates and young infants can impact responses to infections, including sepsis. Here the authors identify that the IL-10/DEL-1 axis is involved in emergency granulopoiesis in neonates and suggest a link to sepsis survival in early life.

  • Eleni Vergadi
  • , Ourania Kolliniati
  •  & Christos Tsatsanis

• Perspective
  27 April 2023 | Open Access

  Less is more: Antibiotics at the beginning of life

  Fear of missing neonatal sepsis has led to early in life antibiotic administration, even without culture-proven sepsis. Here, the authors discuss the potential impact on antimicrobial resistance, and chronic disease later in life, due to effect on the developing microbiome, suggesting a factual based approach in quantifying burden of treatment in relation to the burden of disease.

  • Martin Stocker
  • , Claus Klingenberg
  •  & Eric Giannoni

• Article
  16 February 2022 | Open Access

  Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial

  Here, in a randomized trial of 147 infants receiving distinct antibiotic regimens for early-onset neonatal sepsis, Reyman et al. characterize the gut microbiome and resistance profiles, finding differential effects of antibiotic combinations on microbial community composition and antimicrobial resistance genes.

  • Marta Reyman
  • , Marlies A. van Houten
  •  & Debby Bogaert

• Article
  20 July 2016 | Open Access

  Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis

  Human parechovirus 3 (HPeV3) can cause severe central nervous system infections and is a major cause of neonatal sepsis. Here the authors determine the structure of HPeV3 that provides a high-resolution view of the capsid’s organization and shows multiple interactions of the RNA genome with coat proteins.

  • Shabih Shakeel
  • , Brenda M. Westerhuis
  •  & Sarah J. Butcher

• Article
  14 August 2014 | Open Access

  Identification of a human neonatal immune-metabolic network associated with bacterial infection

  Infection remains a leading cause of morbidity and mortality in neonates worldwide. Here the authors report disproportionate immune stimulatory, co-inhibitory and metabolic pathway responses that specifically mark bacterial infection and can be used to predict sepsis in neonatal patients at the first clinical signs of infection.

  • Claire L. Smith
  • , Paul Dickinson
  •  & Peter Ghazal