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Near-infrared spectroscopy is a form of non-invasive imaging that applies near-infrared radiation (wavelengths 780 nm to 3,000 nm) to chemicals or biological subjects to measure differential absorption. It can measure tissue oxygenation in blood including blood flow changes in the brain cortex for cognitive psychology research.
Accessing longer-wavelength emitting organic fluorophores is critical for diagnostic imaging. Here a series of silicon-RosIndolizine fluorophores with emission maxima at 1,300 nm, 1,550 nm and 1,700 nm were synthesized. The fluorophores generate high-resolution in vivo fluorescence images in mice and establish design principles for future shortwave-infrared fluorophore designs.
Molecular triplet-triplet upconversion is useful in a wide range of applications, but is limited by significant oxygen quenching. Here the authors report the combination of sensitiser and annihilator that is stable in aerated environments, and suitable for in vivo sensing.
The Yb3+ emissions from both the quantum cutting and nearly-pure infrared upconversion and excellent temperature detection were realized in Er3+/Yb3+ co-doped NaY(WO4)2 phosphors.
Ultra-simplified compact spectrometer with a simple, arbitrarily shaped pinhole as the diffracted disperser, eliminating need for encoding and full spectrum calibration, and achieving better than 3 nm spectral peak resolution.
Probing molecules in excited vibrational states requires precise methods to extract the spectroscopic parameters. Here the authors demonstrate optical-optical double-resonance spectroscopy of excited-bands of methane using single pass high power continuous wave pump and cavity-enhanced frequency comb probe.
Reducing the footprint of optical spectrometers is a critical requirement for many in-field applications. Now, a single black phosphorus photodetector with a wavelength-scale size enables mid-infrared computational spectrometry.
The biodistribution of the components of a messenger RNA vaccine following its administration in non-human primates can be non-invasively monitored by labelling the vaccine with a dual radionuclide–near-infrared probe.
