Nanoparticles articles from across Nature Portfolio

A photonic force microscope has been developed with a trapped lanthanide-doped crystal detecting forces as small as 110 aN. This opens new prospects for force sensing in the physical sciences.

In situ reduction deposition is a scalable method for fabricating metal/MXene composites, but rational control remains difficult. Now an in situ reduction strategy for synthesizing metal/MXene composites with precise control over metal size, deposition site and nanostructure has been demonstrated.

This Review explores how machine learning approaches can drive progress in nanotheranostics.

Microfluidic synthesis is an important protocol in multiple synthetic and industrial processes. Here, the influence of key synthetic parameters on the microfluidic synthesis of Zeolitic Imidazolate Frameworks is evaluated, with recommendations given for reproducible synthesis.

Neutrophils are involved in both the initiation and resolution of cardiac inflammation post myocardial infarction (MI). Here, the authors show that intravenously injected nanoparticles can modulate cardiac neutrophils to inhibit inflammation and promote repair for MI therapy.

mRNA delivery through LNPs targeting specific organs holds great clinical potential, but it remains unclear how the structure of the lipidoids in the LNPs controls organ tropism. Here the authors direct in vivo delivery of siloxane-based LNPs via structural alteration of the ionizable structure of the constituting lipidoids.

A photonic force microscope has been developed with a trapped lanthanide-doped crystal detecting forces as small as 110 aN. This opens new prospects for force sensing in the physical sciences.

Monodisperse HgSe nanocrystals are synthesized via Ag⁺ catalysed complete cation exchange with CdSe template nanocrystals.

The oral delivery of difficult-to-drug molecules, such as peptides, can be achieved using milk-derived extracellular vesicles. The Tiny Cargo Company has established a workflow for the large-scale production of extracellular vesicles from milk for the development of XoLacta — an oral therapy that mitigates the side effects of radiation therapy.

The ligand–nanoparticle interface helps to control nanoparticle synthesis and functional properties, but determining its structure and dynamics is challenging owing to the lack of high-resolution direct imaging methods. Now, liquid-phase transmission electron microscopy has uncovered the micellar packing and surface adsorption dynamics of a surfactant ligand on gold nanorods.

Nano-magnetogenetics using magnetic force actuating nanoparticles enables wireless and remote stimulation of targeted deep-brain neurons for studying neural circuits of underlying behaviours.

Getting molecules into cells using viral vectors or electroporation is expensive and laborious. The winner of the Spinoff Prize 2024 is showing that laser-heated nanoparticles could be an alternative solution.