Nanobiotechnology

Nanobiotechnology is a discipline in which tools from nanotechnology are developed and applied to study biological phenomena. For example, nanoparticles can serve as probes, sensors or vehicles for biomolecule delivery in cellular systems.

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News & Views | 06 January 2023

Nanosensors for monitoring plant health
- Juan Pablo Giraldo
- & Sebastian Kruss
Nature Nanotechnology, 1-2
News & Views | 02 January 2023

Real-time monitoring of tumor-homing bacteria and tumor cells in vivo using ultrasound

Nature Biotechnology, 1-2

Latest Research and Reviews

Protocols | 27 January 2023

Scale-up approach for the preparation of magnetic ferrite nanocubes and other shapes with benchmark performance for magnetic hyperthermia applications

This protocol describes a solvothermal-based process to prepare gram-scale ferrite nanoparticles with well-defined shapes (nanocubes, nanostars, faceted and spherical) having heating properties appealing for clinical magnetic hyperthermia treatments.
- Helena Gavilán
- , Giusy M. R. Rizzo
- & Teresa Pellegrino
Nature Protocols, 1-27
Research
24 January 2023 | Open Access

3D RNA-scaffolded wireframe origami

Hybrid nucleic acid origami has potential for biomedical delivery of mRNA and fabrication of artificial ribozymes. Here, the authors use chemical footprinting and cryo-electron microscopy to reveal insights into nucleic acid origami used to fold messenger and ribosomal RNA into 3D polyhedral structures.
- Molly F. Parsons
- , Matthew F. Allan
- & Mark Bathe
Nature Communications 14, 382
Research
24 January 2023 | Open Access

In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy

Cryosurgery can represent a therapeutic option for breast cancer treatment. Here the authors report a strategy combining cryosurgery with cold-responsive nanoparticles loaded with the chemotherapeutic drug irinotecan and PD-L1-targeting siRNA, inducing anti-tumor immune responses in preclinical breast cancer models.
- Wenquan Ou
- , Samantha Stewart
- & Xiaoming He
Nature Communications 14, 392
Research
24 January 2023 | Open Access

Differential sensing with arrays of de novo designed peptide assemblies

Differential sensing aims to mimic senses such as taste and smell through the use of synthetic receptors. Here, the authors show that arrays of de novo designed peptide assemblies can be used as sensor components to distinguish various analytes and complex mixtures.
- William M. Dawson
- , Kathryn L. Shelley
- & Derek N. Woolfson
Nature Communications 14, 383
Protocols | 20 January 2023

A dynamic DNA tetrahedron framework for active targeting

This Protocol Extension presents an updated tetrahedral DNA nanostructure for the delivery of various bioactive molecules that enables an active targeting strategy to be used for stimuli-sensitive conformation changes and on-site cargo release.
- Taoran Tian
- , Tao Zhang
- & Yunfeng Lin
Nature Protocols, 1-28
Research
19 January 2023 | Open Access

Bioprinting microporous functional living materials from protein-based core-shell microgels

Extrusion bioprinting can be used to produce living materials but controlling cell microenvironments is challenging. Here, the authors use a type of core-shell microgel ink that decouples cell culture from material processing to produce functional materials with a range of potential applications.
- Yangteng Ou
- , Shixiang Cao
- & Tuomas P. J. Knowles
Nature Communications 14, 322

All Research & Reviews

News and Comment

Research Highlights | 25 January 2023

Optical filament recording of cellular events

Two new studies in Nature Biotechnology describe cellular recording systems that incorporate time-resolved optical signals into self-assembling protein filaments.
- Darren J. Burgess
Nature Reviews Genetics, 1
Comments & Opinion | 23 January 2023

Wearable breath analysis

Biomarkers in breath can be related to certain diseases, which makes breath-based analysis a powerful diagnostic tool. Here we highlight milestones and remaining challenges for the broad clinical implementation of wearables for breath analysis.
- H. Ceren Ates
- & Can Dincer
Nature Reviews Bioengineering, 1-3
Research Highlights | 09 January 2023

T_reg cell-inducing nanoparticles show promise for treating OA

Lipid nanoparticles loaded with type II collagen and rapamycin can induce antigen-specific regulatory T cell responses and alleviate disease in a mouse model of osteoarthritis.
- Jessica McHugh
Nature Reviews Rheumatology 19, 62
News & Views | 06 January 2023

Nanosensors for monitoring plant health

Nanosensors allow early detection of the onset and type of plant stress for a more precise and sustainable agriculture
- Juan Pablo Giraldo
- & Sebastian Kruss
Nature Nanotechnology, 1-2
News & Views | 02 January 2023

Real-time monitoring of tumor-homing bacteria and tumor cells in vivo using ultrasound

By screening natural prokaryotic gas vesicle gene clusters, we found and engineered new acoustic reporter genes (ARGs) that give bacteria and mammalian cells brighter ultrasound contrast for real-time noninvasive imaging. Expressing these ARGs in engineered cells enabled us to image tumor-homing bacteria and perform genetically guided tumor biopsies in vivo.

Nature Biotechnology, 1-2
News & Views | 22 December 2022

Mapping light distribution in the brain via MRI

Liposomal nanoparticles incorporating photosensitive lipids and enclosing paramagnetic molecules enable the mapping, via magnetic resonance imaging, of spatial variations of light intensity in illuminated brain tissue in living animals.
- Aruna Singh
- & Michael T. McMahon
Nature Biomedical Engineering, 1-3

All News & Comment

Nanobiotechnology

Featured

Nanosensors for monitoring plant health

Real-time monitoring of tumor-homing bacteria and tumor cells in vivo using ultrasound

Latest Research and Reviews

Scale-up approach for the preparation of magnetic ferrite nanocubes and other shapes with benchmark performance for magnetic hyperthermia applications

3D RNA-scaffolded wireframe origami

In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy

Differential sensing with arrays of de novo designed peptide assemblies

A dynamic DNA tetrahedron framework for active targeting

Bioprinting microporous functional living materials from protein-based core-shell microgels

News and Comment

Optical filament recording of cellular events

Wearable breath analysis

T_reg cell-inducing nanoparticles show promise for treating OA

Nanosensors for monitoring plant health

Real-time monitoring of tumor-homing bacteria and tumor cells in vivo using ultrasound

Mapping light distribution in the brain via MRI

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