Myosin

Myosins are a large family of cytoskeletal motor proteins that bind actin and use the energy of ATP hydrolysis to perform diverse functions such as cell motility and contractility, cytokinesis, intracellular trafficking and muscle contraction.

Latest Research and Reviews

  • Research | | open

    Phagocytosis of pathogens is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface. Here authors show that myosin 1e and myosin 1f link the actin cytoskeleton to the membrane and are required for efficient phagocytosis of antibody-opsonized targets.

    • Sarah R. Barger
    • , Nicholas S. Reilly
    • , Maria S. Shutova
    • , Qingsen Li
    • , Paolo Maiuri
    • , John M. Heddleston
    • , Mark S. Mooseker
    • , Richard A. Flavell
    • , Tatyana Svitkina
    • , Patrick W. Oakes
    • , Mira Krendel
    •  & Nils C. Gauthier
  • Research | | open

    Angiogenesis requires dynamic endothelial rearrangements and relative position changes within the vascular tubes. Here the authors show that a PI3K/NUAK1/MYPT1/MLCP pathway regulates actomyosin contractility in endothelial cells and cellular rearrangement during vascular patterning.

    • Ana Angulo-Urarte
    • , Pedro Casado
    • , Sandra D. Castillo
    • , Piotr Kobialka
    • , Maria Paraskevi Kotini
    • , Ana M. Figueiredo
    • , Pau Castel
    • , Vinothini Rajeeve
    • , Maria Milà-Guasch
    • , Jaime Millan
    • , Cora Wiesner
    • , Helena Serra
    • , Laia Muixi
    • , Oriol Casanovas
    • , Francesc Viñals
    • , Markus Affolter
    • , Holger Gerhardt
    • , Stephan Huveneers
    • , Heinz-Georg Belting
    • , Pedro R. Cutillas
    •  & Mariona Graupera
  • Research | | open

    Germline cells in many species are fused to form a syncytium but the mechanics behind the maintenance of these structures are poorly defined. Here, the authors propose an inner contractile actomyosin corset provides a supportive framework to maintain germline architecture in C. elegans.

    • Agarwal Priti
    • , Hui Ting Ong
    • , Yusuke Toyama
    • , Anup Padmanabhan
    • , Sabyasachi Dasgupta
    • , Matej Krajnc
    •  & Ronen Zaidel-Bar
  • Research | | open

    Hypertrophic cardiomyopathy (HCM) is caused by point mutations in sarcomeric proteins. Here the authors develop an optimized model of the sequestered state of cardiac myosin and define the features affecting the lever arm compliance, allowing them to group mutations in classes and to elucidate the molecular mechanisms leading to cardiac dysfunction in HCM.

    • Julien Robert-Paganin
    • , Daniel Auguin
    •  & Anne Houdusse
  • Research | | open

    The actomyosin cytoskeleton is known to spontaneously oscillate in many systems but the mechanism of this behavior is not clear. Here Qin et al. define a signaling network involving a ROCK-dependent self-activation loop and recruitment of myosin II to the cortex, followed by a local accumulation of myosin phosphatase that shuts off the signal.

    • Xiang Qin
    • , Edouard Hannezo
    • , Thomas Mangeat
    • , Chang Liu
    • , Pralay Majumder
    • , Jiaying Liu
    • , Valerie Choesmel-Cadamuro
    • , Jocelyn A. McDonald
    • , Yiyao Liu
    • , Bin Yi
    •  & Xiaobo Wang

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