Myelopoiesis is the process in which innate immune cells, such as neutrophils, dendritic cells and monocytes, develop from a myeloid progenitor cell.

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News and Comment

  • News & Views |

    Activation of TLR–TRAF6 signaling by chronic inflammation in myelodysplastic syndromes increases the competitive advantage of HSPCs harboring MDS mutations through the upregulation of the ubiquitin-modifying enzyme A20 and a switch from canonical to non-canonical NF-κB signaling.

    • Koki Ueda
    • , Rajni Kumari
    •  & Ulrich Steidl
    Nature Immunology 21, 489-490
  • Research Highlights |

    T cells expressing programmed cell death 1 (PD1) have been considered the main targets of immune checkpoint blockade therapy. But a new study shows that targeting PD1 on myeloid cells reprogrammes tumour-induced myelopoiesis to favour maturation of effector myeloid cells that promote antitumour immunity.

    • Lucy Bird
  • News & Views |

    A cell-intrinsic program induces circadian disarming of the toxic machinery of neutrophils in the steady state and prevents tissue injury.

    • Mariana J. Kaplan
    Nature Immunology 21, 104-105
  • Research Highlights |

    Assi et al. have generated multi-omics data on leukaemic blasts from acute myeloid leukaemia (AML) patients with defined genetic alterations. These data provide a comprehensive overview of the specific transcriptional and signalling networks in certain AML subtypes.

    • Katharine H. Wrighton
  • News & Views |

    The human heart contains two macrophage populations with distinct self-maintenance and inflammatory functions. A shift in the balance between these macrophage populations correlates with left-ventricle remodeling and systolic function in patients with heart failure.

    • Freya R. Svedberg
    •  & Martin Guilliams
    Nature Medicine 24, 1091-1092