Conventional dendritic cells

Conventional dendritic cells (cDCs) are innate immune cells. The term cDC refers to all DCs other than plasmacytoid DCs. They reside in tissues and, following tissue infection or injury, they become activated and migrate to draining lymph nodes to promote adaptive immune responses.

Latest Research and Reviews

News and Comment

  • News and Views |

    The N6-methyladenosine (m6A) RNA-modification pathway affects numerous aspects of immune responses. A new study now demonstrates that m6A modification of transcripts encoding lysosomal proteases limits the efficiency of tumor-antigen cross-presentation.

    • Marianne Burbage
    • , Marine Gros
    •  & Sebastian Amigorena
    Nature Immunology 20, 518-520
  • News and Views |

    In the current issue of Nature Immunology, Casanova and colleagues demonstrate that humans (and mouse models) with autosomal-recessive SPPL2a deficiency have a severe defect in conventional dendritic cell 2 survival and production of IL-12 and IL-23, and diminished IFN-γ secretion by mycobacterium-specific memory T cells, thus resulting in increased susceptibility to mycobacterial diseases.

    • Sergio D. Rosenzweig
    Nature Immunology 19, 906-907
  • News and Views |

    Studies using genetic tools have identified the distinct dendritic cell subsets that ensure tolerance to oral antigens in the antigen-rich environment of the gut and suggest a 'division of labor' for protective immunity.

    • Reinhard Hinterleitner
    •  & Bana Jabri
    Nature Immunology 17, 474-476