Myelin biology and repair

Myelin biology and repair refers to the science of myelin physiology, manufacture, and how myelin damage in either the peripheral or central nervous systems can be repaired. Myelin – produced by Schwann cells in the periphery and oligodendrocytes in the CNS – is defective in diseases such as multiple sclerosis, and many myelin repair strategies aim to mitigate this damage.

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Latest Research and Reviews

  • Research | | open

    Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights the involvement of the immune system in disease pathogenesis.

    • Lohith Madireddy
    • , Niklaos A. Patsopoulos
    • , Chris Cotsapas
    • , Steffan D. Bos
    • , Ashley Beecham
    • , Jacob McCauley
    • , Kicheol Kim
    • , Xiaoming Jia
    • , Adam Santaniello
    • , Stacy J. Caillier
    • , Till F. M. Andlauer
    • , Lisa F. Barcellos
    • , Tone Berge
    • , Luisa Bernardinelli
    • , Filippo Martinelli-Boneschi
    • , David R. Booth
    • , Farren Briggs
    • , Elisabeth G. Celius
    • , Manuel Comabella
    • , Giancarlo Comi
    • , Bruce A. C. Cree
    • , Sandra D’Alfonso
    • , Katrina Dedham
    • , Pierre Duquette
    • , Dardiotis Efthimios
    • , Federica Esposito
    • , Bertrand Fontaine
    • , Christiane Gasperi
    • , An Goris
    • , Bénédicte Dubois
    • , Pierre-Antoine Gourraud
    • , Georgios Hadjigeorgiou
    • , Jonathan Haines
    • , Clive Hawkins
    • , Bernhard Hemmer
    • , Rogier Hintzen
    • , Dana Horakova
    • , Noriko Isobe
    • , Seema Kalra
    • , Jun-ichi Kira
    • , Michael Khalil
    • , Ingrid Kockum
    • , Christina M. Lill
    • , Matthew R. Lincoln
    • , Felix Luessi
    • , Roland Martin
    • , Annette Oturai
    • , Aarno Palotie
    • , Margaret A. Pericak-Vance
    • , Roland Henry
    • , Janna Saarela
    • , Adrian Ivinson
    • , Tomas Olsson
    • , Bruce V. Taylor
    • , Graeme J. Stewart
    • , Hanne F. Harbo
    • , Alastair Compston
    • , Stephen L. Hauser
    • , David A. Hafler
    • , Frauke Zipp
    • , Philip De Jager
    • , Stephen Sawcer
    • , Jorge R. Oksenberg
    •  & Sergio E. Baranzini
  • Research | | open

    Monozygotic (MZ) twins are ideal to study the influence of non-genetic factors on complex phenotypes. Here, Souren et al. perform an EWAS in peripheral blood mononuclear cells from 45 MZ twins discordant for multiple sclerosis and identify disease and treatment-associated epigenetic markers.

    • Nicole Y. Souren
    • , Lisa A. Gerdes
    • , Pavlo Lutsik
    • , Gilles Gasparoni
    • , Eduardo Beltrán
    • , Abdulrahman Salhab
    • , Tania Kümpfel
    • , Dieter Weichenhan
    • , Christoph Plass
    • , Reinhard Hohlfeld
    •  & Jörn Walter
  • Research |

    The authors report that the presynaptic protein bassoon forms toxic aggregates in neuronal somata in multiple sclerosis. Stimulation of proteasomal activity reduces bassoon aggregates, neuroaxonal loss and disability during CNS inflammation.

    • Benjamin Schattling
    • , Jan Broder Engler
    • , Constantin Volkmann
    • , Nicola Rothammer
    • , Marcel S. Woo
    • , Meike Petersen
    • , Iris Winkler
    • , Max Kaufmann
    • , Sina C. Rosenkranz
    • , Anna Fejtova
    • , Ulrich Thomas
    • , Aparajita Bose
    • , Simone Bauer
    • , Simone Träger
    • , Katharine K. Miller
    • , Wolfgang Brück
    • , Kent E. Duncan
    • , Gabriela Salinas
    • , Peter Soba
    • , Eckart D. Gundelfinger
    • , Doron Merkler
    •  & Manuel A. Friese
  • Reviews |

    Vaughn et al. review the challenges facing elderly patients with multiple sclerosis (MS). They describe the complex, evolving relationship between ageing and MS pathophysiology, highlight the lack of evidence for the safety and efficacy of disease-modifying therapies in elderly patients, and discuss treatment discontinuation and wellness strategies.

    • Caila B. Vaughn
    • , Dejan Jakimovski
    • , Katelyn S. Kavak
    • , Murali Ramanathan
    • , Ralph H. B. Benedict
    • , Robert Zivadinov
    •  & Bianca Weinstock-Guttman

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