A mutation is any detectable and heritable change in nucleotide sequence that causes a change in genotype and is transmitted to daughter cells and succeeding generations.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Schep et al. show that non-homologous end joining is strongly favoured in euchromatin, whereas single-stranded template repair is moderately preferred in heterochromatin. Importantly, heterochromatin features that promote microhomology-mediated end joining also decrease Cas9 efficiency.

    • Caroline Barranco
  • Research Highlights |

    Two new studies in Science use lineage tracking in humans to show that among the first few embryonic cells originating from post-fertilization cell divisions, there can be substantial imbalance in their contributions to mature tissues.

    • Darren J. Burgess
  • Research Highlights |

    Aitken et al. have used mutagen-induced liver tumours to trace individual strands of the DNA double helix to which damage occurred and correlate this with mutational patterns to inform upon tumour evolution.

    • Anna Dart
  • Research Highlights |

    During ageing, many normal human tissues become a patchwork of mutant clones. Colom et al. show that, in mutagenized mouse oesophageal epithelium, this mutational landscape arises through cell competition, with clone fitness determined by the genotype of their neighbours.

    • Dorothy Clyde