Musculoskeletal system

New research shows that annexin A1 has a protective role in periprosthetic osteolysis and could offer a therapeutic approach to this common cause of arthroplasty failure.

New research has identified the therapeutic potential of a small-molecule inhibitor of the prostaglandin E₂ receptor EP4 against pathophysiology and pain in osteoarthritis.

Preclinical research suggests the focal adhesion protein kindlin-2 protects against intervertebral disc degeneration.

In a rabbit model of osteoarthritis, cartilage regeneration was promoted by a biodegradable implant that generates a piezoelectric response during physical exercise.

Researchers have found that hypoxia in articular cartilage is associated with expression of DOT1L, which protects against cartilage damage in a mouse model of osteoarthritis.