Muscle stem cells

Muscle stem cells are adult stem cells, present in skeletal muscle tissue, which can self-renew and are capable of giving rise to skeletal muscle cells. These stem cells are activated in response to muscle injury to regenerate damaged muscle tissue.

Latest Research and Reviews

News and Comment

  • News and Views |

    Macrophages are required for postinjury skeletal muscle regeneration. A new study reveals that proinflammatory macrophages produce meteorin-like, which promotes muscle stem cell expansion through the Stat3–IGF1 axis and then shifts their inflammatory profile to allow return to homeostasis.

    • Bénédicte Chazaud
    Nature Metabolism 2, 213-214
  • News and Views |

    Skeletal muscle denervation leads to myofibre atrophy with fibrosis and fatty infiltration of muscle-resident fibroadipogenic progenitors (FAPs). A study shows that on denervation, FAPs activate pathogenic STAT3–IL-6 signalling. Inhibition of this pathway prevents atrophy and points to potential therapeutic targets.

    • Giovanna Marazzi
    •  & David Sassoon
    Nature Cell Biology 20, 864-865
  • News and Views |

    To overcome the finite supply of muscle stem cells available for cell therapy, a study now describes a strategy for obtaining an unlimited source of myogenic progenitors derived from human pluripotent cells. Two neuronal cell surface receptors facilitate the selection of a population with enhanced regenerative potential.

    • Andrew T. V. Ho
    •  & Helen M. Blau
  • News and Views |

    Skeletal muscles are composed of different types of fibres. Can these be thought of as distinct lineages with specific lineage-restricted progenitors? A provocative study now proposes that mesenchymal cells expressing the transcription factor Twist2 act as myogenic progenitors with selective type IIb fibre-differentiation potential.

    • Natalya A. Goloviznina
    •  & Michael Kyba
    Nature Cell Biology 19, 153-154
  • News and Views |

    Two recent studies have shown that alterations in muscle stem cell–niche interactions during aging underlie the functional decline in regenerative potential. The reconstitution of this communication restores stem cell function and enhances skeletal muscle repair.

    • Matthew Timothy Tierney
    •  & Alessandra Sacco
    Nature Medicine 22, 837-838