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Muscle contraction is the generation of tension in muscle tissue, often resulting in a lengthening or shortening of the muscle. It involves the formation of rapidly cycling crossbridges between actin filaments and myosin motor proteins.
The intricate molecular architecture and interactions of the human cardiac myosin filament offer insights into cardiac physiology, disease and drug therapy.
Microtubule detyrosination is shown to influence mechanical properties of cardiomyocytes, as detyrosinated microtubules resist the force of contraction by undergoing buckling.
