Multivesicular bodies

  • Article
    | Open Access

    Endoplasmic reticulum (ER)-interorganelle membrane contact sites have emerged as key regulators of organelle dynamics. Here, the authors report that the ER-resident protein SNX19 mediates ER-endolysosome membrane contacts to maintain the perinuclear distribution of endolysosomes and restrict their motility.

    • Amra Saric
    • , Spencer A. Freeman
    •  & Juan S. Bonifacino
  • Article
    | Open Access

    Exosomes are intercellular signaling vesicles created by fusion of multivesicular bodies (MVBs) and the plasma membrane (PM), but secretory regulation is ill-defined. Song et al. show that KIBRA controls exosome secretion by protecting Rab27a from proteasomal degradation, promoting MVB-PM docking.

    • Lin Song
    • , Shi Tang
    •  & Yifeng Du
  • Article
    | Open Access

    Exosomes mediate cell-to-cell communication by transporting proteins, mRNAs, and miRNAs but the mechanisms of protein sorting to exosomes are poorly understood. Here, the authors uncover that ubiquitin-like 3 (UBL3) regulates protein sorting to exosomes by acting as a posttranslational modification.

    • Hiroshi Ageta
    • , Natsumi Ageta-Ishihara
    •  & Kunihiro Tsuchida
  • Article
    | Open Access

    Response to inflammatory stimuli such as endotoxin is coordinated at many levels. Here, the authors show that two microRNAs known to regulate inflammatory response inside the cell are secreted by dendritic cells and modulate inflammatory signalling in the neighbouring cells.

    • Margaret Alexander
    • , Ruozhen Hu
    •  & Ryan M. O’Connell
  • Article
    | Open Access

    A relationship between membrane tension and clathrin polymerization during endocytosis has not been experimentally established. Here, the authors show using an in vitroreconstituted system and theoretical modelling that membrane tension regulates clathrin polymerization into spherical cages by varying the membrane budding energy.

    • Mohammed Saleem
    • , Sandrine Morlot
    •  & Aurélien Roux