Featured
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Article
| Open Access
Organization of the human intestine at single-cell resolution
Intestinal cell types are organized into distinct neighbourhoods and communities within the healthy human intestine, with distinct immunological niches.
- John W. Hickey
- , Winston R. Becker
- & Michael Snyder
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Article |
A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage
Single-cell RNA sequencing and single-molecule RNA transcript imaging have been used to characterize spatially and temporally resolved mouse liver and parasite expression programmes during infection with the rodent malaria parasite Plasmodium berghei ANKA.
- Amichay Afriat
- , Vanessa Zuzarte-Luís
- & Shalev Itzkovitz
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Article
| Open Access
A physical wiring diagram for the human immune system
Systematic measurements of the interactions between proteins found on the surfaces of human leukocytes provides a global view of the way that immune cells are dynamically connected by receptors.
- Jarrod Shilts
- , Yannik Severin
- & Gavin J. Wright
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Phenotypic landscape of intestinal organoid regeneration
An organoid-based screening platform maps the genetic interactions underlying intestinal development and regeneration, showing that retinoic acid metabolism maintains the balance between regeneration and homeostasis, and that an antagonist of the retinoid X receptor promotes regeneration in vivo.
- Ilya Lukonin
- , Denise Serra
- & Prisca Liberali
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Article |
A single-cell survey of the small intestinal epithelium
Profiling of 53,193 individual epithelial cells from the mouse small intestine identifies previously unknown cell subtypes and corresponding gene markers, providing insight into gut homeostasis and response to pathogens.
- Adam L. Haber
- , Moshe Biton
- & Aviv Regev
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Letter |
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
Single-molecule fluorescence in situ hybridization is performed to identify several landmark genes in the liver and their level of expression in single-cell RNA sequencing is used to spatially reconstruct the zonation of all liver genes.
- Keren Bahar Halpern
- , Rom Shenhav
- & Shalev Itzkovitz
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Letter |
Weak synchronization and large-scale collective oscillation in dense bacterial suspensions
Cells in dense bacterial suspensions can self-organize into highly robust collective oscillatory motion, while individual cells move in an erratic manner; their interaction is modelled to reveal a weak synchronization mechanism.
- Chong Chen
- , Song Liu
- & Yilin Wu
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Letter |
Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour
Little is known about how individual cells within a group of cells exposed to the same external signals can produce a specific individual response to their local microenvironment; a quantitative analysis of cell crowding reveals that single cells can autonomously sense local crowding though their ability to spread and activate focal adhesion kinase (FAK), which ultimately results in changes in cellular lipid composition.
- Mathieu Frechin
- , Thomas Stoeger
- & Lucas Pelkmans
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Article |
A promoter-level mammalian expression atlas
A study from the FANTOM consortium using single-molecule cDNA sequencing of transcription start sites and their usage in human and mouse primary cells, cell lines and tissues reveals insights into the specificity and diversity of transcription patterns across different mammalian cell types.
- Alistair R. R. Forrest
- , Hideya Kawaji
- & Yoshihide Hayashizaki
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News |
Ancient macrofossils unearthed in West Africa
Two-billion-year-old fossils could indicate steps towards multicellularity.
- Amy Maxmen
Self-enhanced mobility enables vortex pattern formation in living matter