Mucosal immunology

Mucosal immunology is the study of immune responses that occur at mucosal surfaces, such as the intestines, the urogenital tract and the lungs. These tissues are closely associated with the external environment and the mucosal immune system must provide protective immunity to pathogens but remain tolerant of non-harmful environmental substances.

Latest Research and Reviews

  • Research | | open

    Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells. Furthermore, serum levels of the soluble IL-33 decoy receptor, sST2, are associated with enhanced disease severity in human C. difficile patients.

    • Alyse L. Frisbee
    • , Mahmoud M. Saleh
    • , Mary K. Young
    • , Jhansi L. Leslie
    • , Morgan E. Simpson
    • , Mayuresh M. Abhyankar
    • , Carrie A. Cowardin
    • , Jennie Z. Ma
    • , Patcharin Pramoonjago
    • , Stephen D. Turner
    • , Alice P. Liou
    • , Erica L. Buonomo
    •  & William A. Petri Jr.
  • Research | | open

    Distinguishing clinical subtypes of IBD is critical for optimal treatments, outcome prediction, and better understanding of disease pathogenesis. Here the authors phenotype blood and intestinal immune cells by mass cytometry and identify signatures associated with distinct disease states.

    • Samuel J. S. Rubin
    • , Lawrence Bai
    • , Yeneneh Haileselassie
    • , Gotzone Garay
    • , Chohee Yun
    • , Laren Becker
    • , Sarah E. Streett
    • , Sidhartha R. Sinha
    •  & Aida Habtezion
  • Research |

    Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs

    • Felipe A. Vieira Braga
    • , Gozde Kar
    • , Marijn Berg
    • , Orestes A. Carpaij
    • , Krzysztof Polanski
    • , Lukas M. Simon
    • , Sharon Brouwer
    • , Tomás Gomes
    • , Laura Hesse
    • , Jian Jiang
    • , Eirini S. Fasouli
    • , Mirjana Efremova
    • , Roser Vento-Tormo
    • , Carlos Talavera-López
    • , Marnix R. Jonker
    • , Karen Affleck
    • , Subarna Palit
    • , Paulina M. Strzelecka
    • , Helen V. Firth
    • , Krishnaa T. Mahbubani
    • , Ana Cvejic
    • , Kerstin B. Meyer
    • , Kourosh Saeb-Parsy
    • , Marjan Luinge
    • , Corry-Anke Brandsma
    • , Wim Timens
    • , Ilias Angelidis
    • , Maximilian Strunz
    • , Gerard H. Koppelman
    • , Antoon J. van Oosterhout
    • , Herbert B. Schiller
    • , Fabian J. Theis
    • , Maarten van den Berge
    • , Martijn C. Nawijn
    •  & Sarah A. Teichmann
  • Research | | open

    Emily Wong et al. observe that Mycobacterium tuberculosis (Mtb) infection induces recruitment and expansion of a CD8+ TRAV1-2+ T-cell population in the airways of human patients. T cell receptor analysis showed expansion of this cell population, including oligoclonal MAIT cells, in sites where Mtb antigens are present, suggesting they act as sentinels of pulmonary infection.

    • Emily B. Wong
    • , Marielle C. Gold
    • , Erin W. Meermeier
    • , Bongiwe Z. Xulu
    • , Sharon Khuzwayo
    • , Zuri A. Sullivan
    • , Eisa Mahyari
    • , Zoe Rogers
    • , Hénrik Kløverpris
    • , Prabhat K. Sharma
    • , Aneta H. Worley
    • , Umesh Lalloo
    • , Prinita Baijnath
    • , Anish Ambaram
    • , Leon Naidoo
    • , Moosa Suleman
    • , Rajhmun Madansein
    • , James E. McLaren
    • , Kristin Ladell
    • , Kelly L. Miners
    • , David A. Price
    • , Samuel M. Behar
    • , Morten Nielsen
    • , Victoria O. Kasprowicz
    • , Alasdair Leslie
    • , William R. Bishai
    • , Thumbi Ndung’u
    •  & David M. Lewinsohn

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