Motor neuron

Motor neurons project from the central nervous system to innervate muscle cells to either directly or indirectly control their activity. Contact between a motor neuron and muscle cell is usually via a specialized synapse called a neuromuscular junction.

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  • News and Views |

    Chiot and colleagues investigated whether peripheral macrophages play a role in amyotrophic lateral sclerosis (ALS) pathology, finding that macrophages along peripheral motor neuron axons react to neurodegeneration. Modifying reactive oxygen species (ROS) signaling in peripheral macrophages, using bone marrow cell replacement, reduces both macrophage and microglia inflammatory response, delays pathology and increases survival in ALS mouse models.

    • P. Hande Özdinler
  • Research Highlights |

    The subtype of motor neurons that is most likely to degenerate early in amyotrophic lateral sclerosis is prone to endoplasmic reticulum (ER) stress in mice, owing to low levels of SIL1, an ER-associated protein.

    • Fiona Carr