Morphogenesis articles from across Nature Portfolio

Morphogenesis is the process by which an organism, tissue or organ develops its shape. Morphogenesis is driven by various cellular and developmental processes including cell proliferation, differentiation, apoptosis, cell migration and cell adhesion.

Latest Research and Reviews

Research
05 June 2023 | Open Access

Downregulation of extraembryonic tension controls body axis formation in avian embryos

Extraembryonic tissues provide structural support in addition to signaling inputs. Here they show that extraembryonic structures regulate the mechanical environment of the developing chicken embryo, wherein weakening of the vitelline membrane permits tissue movements that form the body axis.
- Daniele Kunz
- , Anfu Wang
- & Fengzhu Xiong
Nature Communications 14, 3266
Research
05 June 2023 | Open Access

A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest

The authors discovered a far distant genomic region containing multiple clusters of regulatory elements that drive coordinated Hoxa expression across chromatin topologically associating domains in cranial neural crest, and are required for patterning of facial structures.
- Sandra Kessler
- , Maryline Minoux
- & Filippo M. Rijli
Nature Communications 14, 3242
Research
27 May 2023 | Open Access

Directionality of developing skeletal muscles is set by mechanical forces

The mechanisms that drive myocyte orientation and fusion to control muscle directionality are not well understood. Here authors show that the developing skeleton produces mechanical tension that instructs the directional outgrowth of skeletal muscles.
- Kazunori Sunadome
- , Alek G. Erickson
- & Igor Adameyko
Nature Communications 14, 3060
Research
26 May 2023 | Open Access

Early radial positional information in the cochlea is optimized by a precise linear BMP gradient and enhanced by SOX2
- Matthew J. Thompson
- , Caryl A. Young
- & David M. Umulis
Scientific Reports 13, 8567
Research
25 May 2023 | Open Access

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche

Most intestinal organoid models do not accurately model the interactions between epithelial and stromal cells. Here they establish a colon assembloid system with epithelial and stromal cells and demonstrate that BMP signals from differentiating epithelial cells promote mesenchymal niche organization.
- Manqiang Lin
- , Kimberly Hartl
- & Michael Sigal
Nature Communications 14, 3025
Research
17 May 2023 | Open Access

Genome-wide analysis of sex-specific differences in the mother–child PELAGIE cohort exposed to organophosphate metabolites
- Martina Capriati
- , Chunxiang Hao
- & Fatima Smagulova
Scientific Reports 13, 8003

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News and Comment

Editorial | 14 August 2022

Turing patterns, 70 years later

On the 70th anniversary of Alan Turing’s seminal paper on morphogenesis, we look back at the history of the paper and its many applications.

Nature Computational Science 2, 463-464
Research Highlights | 14 July 2022

Multicellular self-organization

Luciano Marcon discusses the revolutionary work by Alan Turing proposing that embryogenesis could be entirely a self-organizing process.
- Luciano Marcon
Nature Reviews Molecular Cell Biology 23, 777
News & Views | 11 July 2022

Deciphering the regulatory logic of a chromatin domain boundary

The boundaries of chromatin domains have an important role in genome organization and regulation. A comprehensive genetic dissection of a domain boundary in vivo provides insights into how boundary elements function and cooperate to mediate insulation between chromatin domains.
- A. Marieke Oudelaar
Nature Genetics 54, 914-915
Research Highlights | 13 January 2022

Cortex expansion by SHR reconfiguration
- Jun Lyu
Nature Plants 8, 18
News & Views | 21 June 2021

The mechanics of crypt morphogenesis

Intestinal organoids have been used to model development of the crypt–villus axis and uncover signalling pathways that govern the stem-cell niche and induce differentiation. Two studies now take advantage of intestinal organoids to measure the mechanical forces that drive morphogenesis of the crypt and fate specification of its resident cells.
- Celeste M. Nelson
Nature Cell Biology 23, 678-679
Research Highlights | 18 February 2020

Looking deeper into tissue elongation

In this Journal Club, Audrey Williams and Sally Horne-Badovinac highlight the importance of studying the basal cell surface and its dynamics to understand epithelial cell behaviours and tissue rearrangements.
- Audrey M. Williams
- & Sally Horne-Badovinac
Nature Reviews Molecular Cell Biology 21, 305

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Morphogenesis articles from across Nature Portfolio

Latest Research and Reviews

Downregulation of extraembryonic tension controls body axis formation in avian embryos

A multiple super-enhancer region establishes inter-TAD interactions and controls Hoxa function in cranial neural crest

Directionality of developing skeletal muscles is set by mechanical forces

Early radial positional information in the cochlea is optimized by a precise linear BMP gradient and enhanced by SOX2

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche

Genome-wide analysis of sex-specific differences in the mother–child PELAGIE cohort exposed to organophosphate metabolites

News and Comment

Turing patterns, 70 years later

Multicellular self-organization

Deciphering the regulatory logic of a chromatin domain boundary

Cortex expansion by SHR reconfiguration

The mechanics of crypt morphogenesis

Looking deeper into tissue elongation

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Morphogenesis articles from across Nature Portfolio

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