Molecular modelling articles from across Nature Portfolio

Bacterial CAX antiporter homolog YfkE can transport Ca²⁺ and inorganic phosphate (P_i) together in a 1:1 ratio, exchanging them for H⁺ and becoming a high-flux antiporter when coupled with P_i.

Engineering protein biosensors that respond to biomolecules by triggering cellular responses has largely relied on binding rigid molecules. Here, the authors develop a computational strategy for designing signaling complexes between conformationally dynamic proteins and peptides.

Using Alpha fold modelling and cryo-EM reconstruction the authors reveal the structural and architectural principles of the bacterial functional amyloid curli, encompassing the continuous stacking of β-solenoid pseudo repeats within and across subunits.