Molecular engineering articles from across Nature Portfolio

Molecular engineering includes methods for the design and synthesis of novel molecules with desirable physical properties or functionalities.

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News & Views | 27 March 2023

A brilliant monomeric red fluorescent protein combining high brightness and fast maturation

Nature Methods, 1-2

Latest Research and Reviews

Research
27 March 2023 | Open Access

Cloning, characterization, and heterologous expression of a candidate Hirudin gene from the salivary gland transcriptome of Hirudo nipponia
- Ping Shi
- , Jian Wei
- & Zenghui Lu
Scientific Reports 13, 4943
Research | 27 March 2023

mScarlet3: a brilliant and fast-maturing red fluorescent protein

Two mScarlet variants with high brightness and fast maturation times have been evolved. These variants behave favorably as fusion tags and Förster resonance energy transfer acceptors.
- Theodorus W. J. Gadella Jr.
- , Laura van Weeren
- & Antoine Royant
Nature Methods, 1-5
Research
24 March 2023 | Open Access

Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets

Induced proximity can be used to control diverse cellular processes. Here, the authors develop nanobody-based proximity inducers called SNACIPs, which can be used to regulate either tagged or endogenous proteins, and demonstrate their use in blocking microtubule nucleation for tumour growth inhibition in vivo.
- Xiaofeng Sun
- , Chengjian Zhou
- & Xi Chen
Nature Communications 14, 1635
Research
17 March 2023 | Open Access

CRISPR-induced DNA reorganization for multiplexed nucleic acid detection

Nucleic acid sensing involving CRISPR technologies is powerful but has certain limitations, such as PAM sequence requirements and limited multiplexing. Here, authors report a CRISPR-based barcoding technology which enables multiple outputs from any target sequence, based on cis- and trans-cleavage.
- Margot Karlikow
- , Evan Amalfitano
- & Keith Pardee
Nature Communications 14, 1505
Research | 15 March 2023

A swapped genetic code prevents viral infections and gene transfer

A study details the creation of an Escherichia coli genetically recoded organism that is resistant to viral infection, and describes a further modification that keeps the organism and its genetic information biocontained.
- Akos Nyerges
- , Svenja Vinke
- & George M. Church
Nature 615, 720-727
Research | 08 March 2023

Co-opting signalling molecules enables logic-gated control of CAR T cells

Logic gating is used to develop a CAR T cell platform that is highly specific and allows the activity of T cells to be restricted to the encounter of two antigens, thus reducing on-target, off-tumour toxicity.
- Aidan M. Tousley
- , Maria Caterina Rotiroti
- & Robbie G. Majzner
Nature 615, 507-516

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News and Comment

Research Highlights | 27 March 2023

De novo luciferases
- Jan-Stefan Völler
Nature Catalysis 6, 216
News & Views | 27 March 2023

A brilliant monomeric red fluorescent protein combining high brightness and fast maturation

We evolved the brilliant monomeric red fluorescent protein mScarlet3 using a multiparameter screening approach. Owing to a newly engineered hydrophobic patch inside its β-barrel structure, mScarlet3 combines a high quantum yield and high fluorescence lifetime with fast and complete maturation. Consequently, mScarlet3 performs well as a fusion tag in live-cell imaging.

Nature Methods, 1-2
Research Highlights | 10 March 2023

SynNotch tuned for tension
- Nina Vogt
Nature Methods 20, 349
News | 13 February 2023

Whisperings from not so silent mutations

This month’s Genome Watch explores how synonymous mutations may have wider implications for protein function than previously acknowledged.
- Nicolas Grosjean
- & Ian K. Blaby
Nature Reviews Microbiology 21, 221
Research Highlights | 10 February 2023

A cell’s growth rings

Two research groups independently develop tools to record the history of cellular dynamics.
- Hui Hua
Nature Methods 20, 174
Research Highlights | 25 January 2023

Optical filament recording of cellular events

Two new studies in Nature Biotechnology describe cellular recording systems that incorporate time-resolved optical signals into self-assembling protein filaments.
- Darren J. Burgess
Nature Reviews Genetics 24, 140

All News & Comment

Molecular engineering articles from across Nature Portfolio

Featured

A brilliant monomeric red fluorescent protein combining high brightness and fast maturation

Latest Research and Reviews

Cloning, characterization, and heterologous expression of a candidate Hirudin gene from the salivary gland transcriptome of Hirudo nipponia

mScarlet3: a brilliant and fast-maturing red fluorescent protein

Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets

CRISPR-induced DNA reorganization for multiplexed nucleic acid detection

A swapped genetic code prevents viral infections and gene transfer

Co-opting signalling molecules enables logic-gated control of CAR T cells

News and Comment

De novo luciferases

A brilliant monomeric red fluorescent protein combining high brightness and fast maturation

SynNotch tuned for tension

Whisperings from not so silent mutations

A cell’s growth rings

Optical filament recording of cellular events

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Molecular engineering articles from across Nature Portfolio

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