Molecular biology

Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules such as nucleic acids and proteins that carry out the biological processes essential for the cells functions and maintenance.

Featured

News & Views | 15 August 2022

Structural keys unlock RAS–MAPK cellular signalling pathway
- Hugo Lavoie
- & Marc Therrien
Nature
News & Views | 12 August 2022

Engineered Cas13 variants with minimal collateral RNA targeting

Nature Biotechnology, 1-2
News & Views | 11 August 2022

Landscape of somatic mutations in aging human heart muscle cells

Nature Aging, 1-2

Latest Research and Reviews

Research
17 August 2022 | Open Access

Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
- Henning T. Langer
- , Agata A. Mossakowski
- & Keith Baar
Cell Death & Disease 13, 716
Research
17 August 2022 | Open Access

In vivo single-molecule analysis reveals COOLAIR RNA structural diversity

The structures of single COOLAIR RNA isoforms change in abundance and shape in response to external conditions; structural mutation of these isoforms altered FLC expression and flowering time, consistent with a regulatory role of the COOLAIR structure in FLC transcription.
- Minglei Yang
- , Pan Zhu
- & Yiliang Ding
Nature, 1-6
Reviews
17 August 2022 | Open Access

The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights
- Qian Xiang
- , Yongzhao Zhao
- & Weishi Li
Experimental & Molecular Medicine, 1-9
Research
17 August 2022 | Open Access

Longitudinal proteomics study of serum changes after allogeneic HSCT reveals potential markers of metabolic complications related to aGvHD
- Sing Ying Wong
- , Seiko Kato
- & Nobuhiro Hayashi
Scientific Reports 12, 14002
Research
17 August 2022 | Open Access

High-temperature ethanol fermentation from pineapple waste hydrolysate and gene expression analysis of thermotolerant yeast Saccharomyces cerevisiae
- Huynh Xuan Phong
- , Preekamol Klanrit
- & Pornthap Thanonkeo
Scientific Reports 12, 13965
Research
17 August 2022 | Open Access

Live-seq enables temporal transcriptomic recording of single cells

Live-seq, a single-cell transcriptome profiling approach that preserves cell viability during RNA extraction using fluidic force microscopy, can address a range of biological questions by transforming scRNA-seq from an end-point to a temporal analysis approach.
- Wanze Chen
- , Orane Guillaume-Gentil
- & Bart Deplancke
Nature, 1-8

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News and Comment

News & Views | 15 August 2022

Structural keys unlock RAS–MAPK cellular signalling pathway

Activation of the RAF protein is key to the RAS–MAPK signalling pathway, and involves the SMP protein complex. Structures for SMP shed light on the process, and suggest fresh targets for anticancer drug discovery.
- Hugo Lavoie
- & Marc Therrien
Nature
News & Views | 12 August 2022

Engineered Cas13 variants with minimal collateral RNA targeting

The application of CRISPR–Cas13 for targeted RNA degradation is hindered by the existence of collateral effects induced by Cas13. We screened hundreds of engineered Cas13 variants using a convenient and sensitive reporter system and obtained several variants with markedly reduced collateral activity and efficient on-target activity, suitable for in vivo applications.

Nature Biotechnology, 1-2
News & Views | 11 August 2022

Landscape of somatic mutations in aging human heart muscle cells

Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.

Nature Aging, 1-2
Research Highlights | 10 August 2022

‘Poisoning’ of the transcriptome by ultraconserved elements

Leclair and Anczuków describe how high-throughput screens uncovered the connection between poison exons and cancer.
- Nathan K. Leclair
- & Olga Anczuków
Nature Reviews Molecular Cell Biology, 1
News & Views | 10 August 2022

Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST

CST is both an ssDNA-binding complex and a DNA Pol-α/primase cofactor that coordinates the switch from G-strand elongation to C-strand fill-in during telomere maintenance. Four papers in Nature Structural & Molecular Biology and Nature provide transformative insights into CST activity, providing a platform to understand lagging-strand synthesis genome wide.
- Conner L. Olson
- , Alexandra T. Barbour
- & Deborah S. Wuttke
Nature Structural & Molecular Biology 29, 730-733
Editorial
10 August 2022 | Open Access

Molecular explorations of cancer biology and therapeutics at PDB-101
- David S. Goodsell
- , Shuchismita Dutta
- & Stephen K. Burley
Oncogene, 1-3

All News & Comment

Molecular biology

Featured

Structural keys unlock RAS–MAPK cellular signalling pathway

Engineered Cas13 variants with minimal collateral RNA targeting

Landscape of somatic mutations in aging human heart muscle cells

Latest Research and Reviews

Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats

In vivo single-molecule analysis reveals COOLAIR RNA structural diversity

The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights

Longitudinal proteomics study of serum changes after allogeneic HSCT reveals potential markers of metabolic complications related to aGvHD

High-temperature ethanol fermentation from pineapple waste hydrolysate and gene expression analysis of thermotolerant yeast Saccharomyces cerevisiae

Live-seq enables temporal transcriptomic recording of single cells

News and Comment

Structural keys unlock RAS–MAPK cellular signalling pathway

Engineered Cas13 variants with minimal collateral RNA targeting

Landscape of somatic mutations in aging human heart muscle cells

‘Poisoning’ of the transcriptome by ultraconserved elements

Filling in the blanks: how the C-strand catches up to the G-strand at replicating telomeres using CST

Molecular explorations of cancer biology and therapeutics at PDB-101

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