Model fungi articles within Nature Communications

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  • Article
    | Open Access

    Using a microfluidic single-cell aging platform, the authors report how single-cell lifespan varies across more than 300 yeast strains, each missing a single gene. Their top hit, Sis2, was found to regulate yeast lifespan in a dose-dependent fashion.

    • Tolga T. Ölmez
    • , David F. Moreno
    •  & Murat Acar

  • Article
    | Open Access

    Protein aggregates are a hallmark of neurodegenerative disease and aging. Here, Fischbach et al. report engineered, artificial systems to re-localise or export protein aggregates from cells, with preliminary data showing that mHtt inclusions in S. cerevisiae may be cytotoxic.

    • Arthur Fischbach
    • , Angela Johns
    •  & Thomas Nyström

  • Article
    | Open Access

    Here, the authors describe the geographies, hosts, substrates, and phylogenetic relationships for 1,794 Saccharomyces strains. They provide insight into the genetic and phenotypic diversity in the genus, not seen through prior work focused on the model species Saccharomyces cerevisiae.

    • David Peris
    • , Emily J. Ubbelohde
    •  & Chris Todd Hittinger

  • Article
    | Open Access

    Antibiotic and anti-cancer therapy are challenged by mutation-mediated treatment resistance despite many mutations being maladaptive. Here, the authors introduce a system that shows how the probability of the long-term persistence of drug-resistant mutant lineages can be increased in dense microbial populations by acquiring multiple mutations.

    • Serhii Aif
    • , Nico Appold
    •  & Jona Kayser

  • Article
    | Open Access

    Increasing the number of chromosome sets alters the physiology of cells. Here, the authors show that although the number of chromosome sets increases, the proteome does not scale linearly with the increasing ploidy.

    • G. Yahya
    • , P. Menges
    •  & Z. Storchova

  • Article
    | Open Access

    Microbial production of cannabinoids promises a cheaper and more sustainable route to these important therapeutic molecules, but strain improvement and screening is challenging. Here, the authors develop a yeast-based Δ9-tetrahydrocannabinol (THC) biosensor for screening microbial mutant libraries.

    • William M. Shaw
    • , Yunfeng Zhang
    •  & Tom Ellis

  • Article
    | Open Access

    Yeast exhibit oscillations that share features with circadian rhythms. The authors show that bioenergetic constraints promote oscillatory behaviour: resources are stored until supplies can support translational bursting, this is licensed by ion transport and release from membrane-less compartments.

    • John S. O’Neill
    • , Nathaniel P. Hoyle
    •  & Helen C. Causton

  • Article
    | Open Access

    Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the mechanisms that promote tolerance of aneuploidy.

    • Alaattin Kaya
    • , Marco Mariotti
    •  & Vadim N. Gladyshev

  • Article
    | Open Access

    An essential gene may become non-essential when another gene is mutated. Here, the authors investigate this type of digenic interaction, termed ‘bypass of essentiality’, in the fission yeast Schizosaccharomyces pombe, and show that bypassable essential genes are common and share certain features.

    • Jun Li
    • , Hai-Tao Wang
    •  & Li-Lin Du

  • Article
    | Open Access

    The transcription factor Gcn4 is known to regulate yeast amino acid synthesis. Here, the authors show that Gcn4 also acts as a repressor of protein biosynthesis in a range of conditions that enhance yeast lifespan, such as ribosomal protein knockout, calorie restriction or mTOR inhibition.

    • Nitish Mittal
    • , Joao C. Guimaraes
    •  & Mihaela Zavolan

  • Article
    | Open Access

    Here, Richard Kolodner and colleagues use assays in Saccharomyces cerevisiaeto identify 182 genetic modifiers of gross chromosomal rearrangements (GCRs). They also compared these Genome Instability Suppressing (GIS) genes and pathways in human cancer genome, and found many ovarian and colorectal cancer cases have alterations to GIS pathways.

    • Christopher D. Putnam
    • , Anjana Srivatsan
    •  & Richard D. Kolodner

  • Article
    | Open Access

    Cell shape is determined by a combination of biochemical regulation and mechanical forces. By imaging the dynamic behaviour of growth regulatory proteins in fission yeast and integrating these data within a mechanical model, Abenza et al. find that exocytosis plays a dominant role in shaping growth domains.

    • Juan F. Abenza
    • , Etienne Couturier
    •  & Rafael E. Carazo Salas

  • Article
    | Open Access

    The evolutionarily conserved MTREC complex promotes degradation of meiotic mRNAs and regulatory ncRNAs. Here the authors show that MTREC also targets cryptic unstable transcripts and unspliced pre-mRNAs for degradation by the nuclear exosome, while the TRAMP complex has only a minor role in this process.

    • Yang Zhou
    • , Jianguo Zhu
    •  & Tamás Fischer

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