Mobile elements

Mobile elements are DNA sequences that can move around the genome, changing their number of copies or simply changing their location, often affecting the activity of nearby genes. They include DNA transposable elements, plasmids and bacteriophage elements. The total of all mobile genetic elements in a genome may be referred to as the mobilome.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    In this Journal Club article, Geoff Faulkner discusses how a ground-breaking study of LINE-1 mobility in human genomes demonstrated not just a role in disease but also molecular details of the mechanisms of retrotransposition.

    • Geoffrey J. Faulkner
  • Research Highlights |

    A study in Nature Communications shows that horizontal transfer of bacterial chromosomes by phage-mediated lateral transduction renders them more mobile than many classically defined mobile genetic elements, including plasmids and transposons.

    • Dorothy Clyde
  • Research Highlights |

    Two recent studies demonstrate that putative nucleases encoded by IS200/IS605 family transposons are programmable RNA-guided DNA endonucleases, which could represent a new source of genome-editing enzymes for biotechnological applications.

    • Grant Otto
  • Research Highlights |

    Two papers in Nature Plants provide evidence that plants, like mammals, regulate gene expression from long-range cis-regulatory elements (CREs). Plant CREs are widespread and have distinct evolutionarily conserved chromatin characteristics that are predictive of their effect on gene expression.

    • Dorothy Clyde