Mitosis is the complex process in which duplicated chromosomes are condensed, segregated with the help of the mitotic spindle, and packaged in to daughter cell nuclei. Mitosis occurs in five stages: prophase, prometaphase, metaphase, anaphase and telophase.

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  • News & Views |

    The collapse of DNA replication forks leads to the formation of single-ended DNA double-strand breaks. One would have assumed that these breaks would be repaired as soon as possible. However, a recent study suggests that a delay in DNA polymerase θ-mediated end joining until mitosis, orchestrated by BRCA2 and RAD52, favors genomic stability.

    • Michalis Petropoulos
    •  & Thanos D. Halazonetis
    Nature Cell Biology 23, 1055-1057
  • News & Views |

    Assembly of the mitotic spindle requires timely separation of the centrosomes. Their movement apart is driven by the plus-end-directed kinesin Eg5. A new study demonstrates that the kinesin KIFC3 provides an opposing microtubule-based cohesive force that modulates centrosome separation and ensures accurate chromosome segregation.

    • Ciaran G. Morrison
    Nature Cell Biology 21, 1057-1059
  • News & Views |

    During mitosis, the kinetochore connects chromosomes to spindle microtubules and enables chromosome segregation. A genetic study in vertebrate cells demonstrates phosphorylation-regulated plasticity of kinetochore assembly and highlights the role of the centromere protein T in load-bearing kinetochore–microtubule attachment.

    • Yang Yang
    •  & Hongtao Yu
    Nature Cell Biology 20, 1335-1337