Mitosis articles within Nature Communications

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  • Article
    | Open Access

    Cytokinesis in budding yeast is accompanied by a major rearrangement of septins into a double ring. Here, authors show that the F-BAR protein Hof1 contributes to septin remodeling upon its phosphorylation and relocalisation from septins to the division site.

    • Maritzaida Varela Salgado
    • , Ingrid E. Adriaans
    •  & Simonetta Piatti

  • Article
    | Open Access

    Lipid synthesis increases during the cell cycle to ensure sufficient membrane mass. Here, authors identify a lipid checkpoint in G1 phase that prevents cells from starting the cell cycle if lipid synthesis is low, thereby preventing mitotic defects.

    • Marielle S. Köberlin
    • , Yilin Fan
    •  & Tobias Meyer

  • Article
    | Open Access

    The detailed 3D organization of human centromere components is unknown. Here, the authors use super-resolution microscopy to present a working model for a common core centromere structure.

    • Ayantika Sen Gupta
    • , Chris Seidel
    •  & Jennifer L. Gerton

  • Article
    | Open Access

    Methyl-phos switches on histones have been shown to regulate reader protein displacement from chromatin. However, in this study the authors find that H3T3ph is not required to remove transcription factors from H3K4me3 in mitosis. This might help to preserve promoter properties during cell division.

    • Rebecca J. Harris
    • , Maninder Heer
    •  & Jonathan M. G. Higgins

  • Article
    | Open Access

    Most transcription factors detach from chromatin during mitosis, but some are retained and bookmark genomic sites. Here, the authors show that GATA2-mediated mitotic bookmarking is critical for definitive haematopoiesis.

    • Rita Silvério-Alves
    • , Ilia Kurochkin
    •  & Carlos-Filipe Pereira

  • Article
    | Open Access

    cGAS/STING activation is linked to the induction of anti-tumor immune responses. Here the authors report a role for the deubiquitinating enzyme TRABID in regulating mitotic cell division and suppressing anti-tumor immunity, suggesting that TRABID inhibition induces micronuclei and activates cGAS/STING pathway.

    • Yu-Hsuan Chen
    • , Han-Hsiun Chen
    •  & Ruey-Hwa Chen

  • Article
    | Open Access

    Human papillomavirus (HPV) coopts mitosis for nuclear entry by tethering the viral DNA to mitotic chromosomes, a process facilitated by the viral minor capsid protein L2. Here, Rizzato et al. show that L2 contains conserved phosphorylation motifs within the chromosome-binding region and provide evidence that host master mitotic kinases CDK1 and PLK1 sequentially mediate phosphorylation of L2 at mitosis onset to allow timely tethering of viral DNA to mitotic chromosomes.

    • Matteo Rizzato
    • , Fuxiang Mao
    •  & Mario Schelhaas

  • Article
    | Open Access

    Regulation of oriented cell divisions during development is important to position daughter cells and build a structured and functional tissue. Here the authors show that Annexin A1 is a key polarity protein that regulates planar orientation of the cell division axis to guide mammary epithelial morphogenesis.

    • Maria Fankhaenel
    • , Farahnaz S. Golestan Hashemi
    •  & Salah Elias

  • Article
    | Open Access

    Bahn et al explore the role of the lipid raft protein Prominin-1 in liver regeneration. They show that Prominin-1 promotes hepatocyte proliferation after acute liver injury by interacting with the signal transducer GP130, confining it to lipid rafts and activating IL-6 signaling pathway and eventual activation of STAT3.

    • Myeong-Suk Bahn
    • , Dong-Min Yu
    •  & Young-Gyu Ko

  • Article
    | Open Access

    Chromosomal instability caused by cell division errors is associated with antifungal drug resistance in fungal pathogens. Here, Jaitly et al. identify several genes involved in chromosomal stability in Candida albicans, including a phylogenetically restricted gene encoding an essential cell-cycle progression factor.

    • Priya Jaitly
    • , Mélanie Legrand
    •  & Kaustuv Sanyal

  • Article
    | Open Access

    In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei formation and chromosomal instability.

    • Mara De Marco Zompit
    • , Mònica Torres Esteban
    •  & Manuel Stucki

  • Article
    | Open Access

    The Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is coordinated with the cell cycle is unclear. Here, the authors show with Drosophila sensory organ precursor cells that Cyclin A is recruited in prophase by Frizzled/Dishevelled, regulating division orientation.

    • Pénélope Darnat
    • , Angélique Burg
    •  & Agnès Audibert

  • Article
    | Open Access

    Female carriers of BRCA1 mutations possess high breast cancer risk, which may reflect deficient growth control of mammary progenitor cells. Here, the authors study progenitor-enriched fractions from these carriers and describe a loss of PLK1-mediated mitotic spindle positioning and an inability of the progeny to acquire features of mature luminal cells.

    • Zhengcheng He
    • , Ryan Ghorayeb
    •  & Christopher A. Maxwell

  • Article
    | Open Access

    The cell cycle regulates translation during mitosis by controlling DENR stability. Here, the authors show the non-canonical translation initiation complex DENR·MCTS1 is phosphorylated during mitosis by CDK1 and 2, enabling the translation of genes needed for proper mitotic progression.

    • Katharina Clemm von Hohenberg
    • , Sandra Müller
    •  & Aurelio A. Teleman

  • Article
    | Open Access

    PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of chromosome segregation and successful cell division.

    • Silvia Martini
    • , Khalil Davis
    •  & Peter J. Parker

  • Article
    | Open Access

    RAD51 is a well known player of DNA repair and homologous recombination. Here the authors reveal a function for RAD51 in protecting under-replicated DNA in mitotic human cells, promoting mitotic DNA synthesis (MiDAS) and successful chromosome segregation.

    • Isabel E. Wassing
    • , Emily Graham
    •  & Fumiko Esashi

  • Article
    | Open Access

    Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations of compartmental interactions after mitosis. Furthermore, they show global 3D architecture is set up without transcription, but that transcription contributes to proper gene domain formation.

    • Haoyue Zhang
    • , Jessica Lam
    •  & Gerd A. Blobel

  • Article
    | Open Access

    Progression of the cell division cycle requires feedback loops including those of phosphorylation and dephosphorylation; however the precise regulation of phosphorylation kinetics of Arpp19, an inhibitor of protein phosphatase 2A, is unclear. Here, the authors report that feedback between phosphorylation states of Ser67 and Ser109 of Arpp19 coordinates Arpp19-dependent inhibition of PP2A-B55 and Cyclin B activation during cell cycle progression.

    • Jean Claude Labbé
    • , Suzanne Vigneron
    •  & Thierry Lorca

  • Article
    | Open Access

    It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell proliferation.

    • Chen Jiang
    • , Ahsan Javed
    •  & Thomas Worzfeld

  • Article
    | Open Access

    Kinesin motor proteins are critical for maintaining mitotic spindle integrity, which is important for chromosome stability. Here, the authors show that the kinesin motor protein, KIF18A, permits the proliferation of chromosomally unstable cells and knockdown of KIF18A induces centrosome fragmentation.

    • Carolyn Marquis
    • , Cindy L. Fonseca
    •  & Jason Stumpff

  • Article
    | Open Access

    ATP drives most cellular processes, although ATP production and consumption levels during mitosis remain unreported. Here, the authors combine metabolic measurements and modeling to quantify ATP levels and synthesis dynamics, revealing that ATP synthesis and consumption are lowered during mitosis.

    • Joon Ho Kang
    • , Georgios Katsikis
    •  & Teemu P. Miettinen

  • Article
    | Open Access

    The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM structures that provide insight into MiDAC’s mode of assembly.

    • Robert E. Turnbull
    • , Louise Fairall
    •  & John W. R. Schwabe

  • Article
    | Open Access

    Long noncoding RNAs (lncRNAs) regulate key steps of cell division. Here, the authors perform a comprehensive RNAi imaging screen targeting more than 2,000 human lncRNAs, and suggest a role of chromatin-associated linc00899 in regulation of cell division by suppressing the transcription of microtubule-binding protein TPPP/p25.

    • Lovorka Stojic
    • , Aaron T. L. Lun
    •  & Fanni Gergely

  • Article
    | Open Access

    In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε. Here, the authors show that this switch protects from chromosome non-disjunction by delaying anaphase entry and promoting TopoIIα-dependent resolution.

    • Joanna R. Kelly
    • , Silvia Martini
    •  & Tanya N. Soliman

  • Article
    | Open Access

    The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin ligase complex 4 (CRL4) in regulating metaphase to anaphase transition via BUB3 degradation.

    • Sang-Min Jang
    • , Jenny F. Nathans
    •  & Mirit I. Aladjem

  • Article
    | Open Access

    Golgi disassembly is required for mitosis and occurs by vesicle fusion suppression, although the mechanism is unclear. Here, Chang et al. show, with quantitative analyses and crystallography, that Importin-α regulates this process by blocking GM130-p115 interactions in a Ran pathway-independent way.

    • Chih-Chia Chang
    • , Ching-Jou Chen
    •  & Kuo-Chiang Hsia

  • Article
    | Open Access

    Centrosomes drive mitotic spindle formation and chromosome segregation. Here, the authors show that centrosome stability is regulated by selective autophagic degradation of centriolar satellite components in a process they term doryphagy, connecting autophagy and chromosomal integrity.

    • Søs Grønbæk Holdgaard
    • , Valentina Cianfanelli
    •  & Francesco Cecconi

  • Article
    | Open Access

    The intermediate filament vimentin reorganizes during mitosis, but its molecular regulation and impact on the cell during cell division is unclear. Here, the authors show that vimentin filaments redistribute to the cell cortex during mitosis intertwining with and affecting actin organization.

    • Sofia Duarte
    • , Álvaro Viedma-Poyatos
    •  & Dolores Pérez-Sala

  • Article
    | Open Access

    Chromosome instability can be caused by replication stress, although the mechanism is unclear. Here, the authors show that inducing mild replication stress in cancerous and non-cancerous cell lines leads to centriole disengagement and the subsequent formation of lagging chromosomes and micronuclei.

    • Therese Wilhelm
    • , Anna-Maria Olziersky
    •  & Patrick Meraldi

  • Article
    | Open Access

    Correct spindle positioning is critical for cell division but the full set of proteins regulating this is unclear. Here, with a live imaging siRNA-based screen in human cells, the authors identify 16 candidates required for this process, 11 of which were previously unassociated with such a function, including TYRO3 and GAK.

    • Benita Wolf
    • , Coralie Busso
    •  & Pierre Gönczy

  • Article
    | Open Access

    During cell division, faithful chromosome segregation requires proper chromosome congression and dynamic maintenance of the aligned chromosomes. Here, the authors find that LUBAC promotes dynamic chromosome congression and alignment by targeting kinetochore motor CENP-E to the KMN network.

    • Min Wu
    • , Yan Chang
    •  & Huiyan Li

  • Article
    | Open Access

    Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape.

    • Paul Adrian Ginno
    • , Lukas Burger
    •  & Dirk Schübeler

  • Article
    | Open Access

    One of the determinants of the neuronal subtype produced from retinal progenitor cells is their proliferative potential. Here the authors show that mTORC1 promotes progenitor cell cycle progression and hence accelerated development in mouse retina through induction of the immunoproteasome which enhances the degradation of cyclins.

    • Ji-Heon Choi
    • , Hong Seok Jo
    •  & Jin Woo Kim

  • Article
    | Open Access

    The temporal activation of kinases and timely ubiquitin-mediated degradation is central to faithful mitosis. Here the authors show that acetylation controlled by Coenzyme A synthase (COASY) and acetyltransferase CBP constitutes a mechanism that ensures faithful mitosis.

    • Chao-Chieh Lin
    • , Mayumi Kitagawa
    •  & Jen-Tsan Chi

  • Article
    | Open Access

    Kinetochores (KT) that are not attached to microtubules prevent chromosome missegregation via the spindle assembly checkpoint. Here the authors show that Mps1 localizes Stu1 at unattached KTs together with Slk19, causing a reorganization of the nuclear MT network that favors the capturing of unattached KT.

    • Caroline Kolenda
    • , Jennifer Ortiz
    •  & Johannes Lechner

  • Article
    | Open Access

    Polarized localization of Numb and Pon in Drosophila neuroblasts (NBs) enables their unequal segregation during asymmetric cell divisions. Here, the authors demonstrate liquid-liquid phase separation of Pon and Numb in NBs mediated by multivalent intermolecular interactions is required for their basal condensation.

    • Zelin Shan
    • , Yuting Tu
    •  & Wenyu Wen

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