Featured
-
-
Article
| Open Access
Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice
The mechanism of CGRP-evoked peripheral pain is unclear. Here, the authors show that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.
- Francesco De Logu
- , Romina Nassini
- & Pierangelo Geppetti
-
Article
| Open Access
Astrocyte deletion of α2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway
Mutations of α2-Na/K ATPase can cause familial hemiplegic migraine via unclear mechanisms. Here, the authors show that deletion of α2-Na/K ATPase in astrocytes results in gene expression and metabolic changes leading to cortical spreading depression and episodic transient motor paralysis in mice.
- Sarah E. Smith
- , Xiaoying Chen
- & Azad Bonni
-
Article
| Open Access
A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine
The association between blood pressure (BP) and migraine is poorly understood. Here, the authors explore this relationship using summary-level GWAS data for BP and migraine. Cross-trait meta-analysis reveals shared loci between BP and migraine, while Mendelian randomization suggests that diastolic BP specifically plays a key role in migraine susceptibility.
- Yanjun Guo
- , Pamela M. Rist
- & Daniel I. Chasman
-
Article
| Open Access
Maladaptive activation of Nav1.9 channels by nitric oxide causes triptan-induced medication overuse headache
The precise mechanisms that lead to medication-overuse headaches (MOH), which can occur with both over-the-counter and prescription pain-relief medicines, are still uncertain. In this study, authors show that the abnormal activation of dural nociceptor Nav1.9 channels by Nitric Oxide is responsible for triptan-induced MOH, causing hyperexcitability of dural nociceptors and headache.
- Caroline Bonnet
- , Jizhe Hao
- & Patrick Delmas
Genetic analyses identify pleiotropy and causality for blood proteins and highlight Wnt/β-catenin signalling in migraine