Microglial cells

Microglial cells are a specialised population of macrophages that are found in the central nervous system (CNS). They remove damaged neurons and infections and are important for maintaining the health of the CNS.

Latest Research and Reviews

  • Research |

    Oxidative stress can promote neurodegeneration. Akassoglou and colleagues describe Tox-seq, a functional single-cell RNA sequencing method to identify oxidative stress transcriptional signatures in CNS-resident cells. Tox-seq identified coagulation and glutathione-redox pathway genes that are coupled to oxidative stress and that could be targeted by the glutathione-regulating small molecule acivicin.

    • Andrew S. Mendiola
    • , Jae Kyu Ryu
    • , Sophia Bardehle
    • , Anke Meyer-Franke
    • , Kenny Kean-Hooi Ang
    • , Chris Wilson
    • , Kim M. Baeten
    • , Kristina Hanspers
    • , Mario Merlini
    • , Sean Thomas
    • , Mark A. Petersen
    • , Alexander Williams
    • , Reuben Thomas
    • , Victoria A. Rafalski
    • , Rosa Meza-Acevedo
    • , Reshmi Tognatta
    • , Zhaoqi Yan
    • , Samuel J. Pfaff
    • , Michael R. Machado
    • , Catherine Bedard
    • , Pamela E. Rios Coronado
    • , Xiqian Jiang
    • , Jin Wang
    • , Michael A. Pleiss
    • , Ari J. Green
    • , Scott S. Zamvil
    • , Alexander R. Pico
    • , Benoit G. Bruneau
    • , Michelle R. Arkin
    •  & Katerina Akassoglou
    Nature Immunology 21, 513-524
  • Research |

    The authors identify two subsets of peripheral nerve macrophages residing in the endoneurium and the epineurium and displaying a distinct transcriptome and response to injury. These cells lack the main microglia identity and have a distinct origin.

    • Elke Ydens
    • , Lukas Amann
    • , Bob Asselbergh
    • , Charlotte L. Scott
    • , Liesbet Martens
    • , Dorine Sichien
    • , Omar Mossad
    • , Thomas Blank
    • , Sofie De Prijck
    • , Donovan Low
    • , Takahiro Masuda
    • , Yvan Saeys
    • , Vincent Timmerman
    • , Ralf Stumm
    • , Florent Ginhoux
    • , Marco Prinz
    • , Sophie Janssens
    •  & Martin Guilliams
    Nature Neuroscience 23, 676-689
  • Research |

    The authors show that NLRP3 inflammasome is activated in microglia of patients with fronto-temporal dementia and in a mouse model of tau pathology, and that the loss of NLRP3 inflammasome function decreases tau pathology and improves cognition in mice.

    • Christina Ising
    • , Carmen Venegas
    • , Shuangshuang Zhang
    • , Hannah Scheiblich
    • , Susanne V. Schmidt
    • , Ana Vieira-Saecker
    • , Stephanie Schwartz
    • , Shadi Albasset
    • , Róisín M. McManus
    • , Dario Tejera
    • , Angelika Griep
    • , Francesco Santarelli
    • , Frederic Brosseron
    • , Sabine Opitz
    • , James Stunden
    • , Maximilian Merten
    • , Rakez Kayed
    • , Douglas T. Golenbock
    • , David Blum
    • , Eicke Latz
    • , Luc Buée
    •  & Michael T. Heneka
    Nature 575, 669-673
  • Research |

    Van Hove et al. reveal the diversity of macrophages at the brain’s border regions via single-cell analysis and fate-mapping. This also identified a microglial subset at the surface of the choroid plexus, in direct contact with cerebrospinal fluid.

    • Hannah Van Hove
    • , Liesbet Martens
    • , Isabelle Scheyltjens
    • , Karen De Vlaminck
    • , Ana Rita Pombo Antunes
    • , Sofie De Prijck
    • , Niels Vandamme
    • , Sebastiaan De Schepper
    • , Gert Van Isterdael
    • , Charlotte L. Scott
    • , Jeroen Aerts
    • , Geert Berx
    • , Guy E. Boeckxstaens
    • , Roosmarijn E. Vandenbroucke
    • , Lars Vereecke
    • , Diederik Moechars
    • , Martin Guilliams
    • , Jo A. Van Ginderachter
    • , Yvan Saeys
    •  & Kiavash Movahedi
    Nature Neuroscience 22, 1021-1035

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