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Microfluidics is the engineering or use of devices that apply fluid flow to channels smaller than 1 millimetre in at least one dimension. Microfluidic devices can reduce reagent consumption, allow well controlled mixing and particle manipulation, integrate and automate multiple assays (known as lab-on-a-chip), and facilitate imaging and tracking.
Exosomal PD-L1 (exoPD-L1) is a biomarker predicting immunotherapeutic responses. Here the authors report NanoEPIC, a nanoscale cytometry platform that enables phenotypic sorting and exoPD-L1 profiling from blood plasma by using magnetic-activated ranking to differentiate exosomal subpopulations.
Human-based in vitro models, such as organoids and organs-on-chips, may have the potential to replace certain animal models in preclinical research. But how much ‘human’ is needed in these models?
An article in Nature Nanotechnology reports a nanopore-based single-molecule sensing method that allows control over the translocation speed of the measured molecule.
Academic scientists who develop entrepreneurial capabilities can make strategic, path dependent decisions that enable university spin-offs to rapidly respond to global crises.
