Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Microarray analysis is a method that uses microchips containing anchored arrays of short DNA elements (known as probes) for the large-scale interrogation of gene expression. Nucleic acid samples are labelled and applied to the arrays, and hybridization to specific probes is identified by imaging and subsequent data processing.
A single cell-based approach to characterize human induced pluripotent stem cells resistant to differentiation finds cellular properties of neural and mesenchymal origins, pointing at underlying causes for undesired grafts after transplantation.
BayesR3 samples the polymorphisms affecting complex traits at reduced computational cost to predict the genetic value, breeding value, or individual risk of genotypes.
RNA microarrays have many potential applications, but are difficult to produce. Here, the AUs present a method for converting commercial, customizable DNA microarrays into RNA microarrays using an accessible three-step process involving primer photocrosslinking, extension, and template degradation.
Humans deficient in the adaptor MyD88 or the kinase IRAK4 suffer from primary immunodeficiency. Blood cells from these patients show defective induction of specific subsets of genes after exposure to microbial stimuli in vitro.
