Featured
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H1 histones control the epigenetic landscape by local chromatin compaction
Experiments using a conditional triple-knockout mouse strain show that histone H1 regulates the activity of chromatin domains by controlling chromatin compaction, genome architecture and histone methylation.
- Michael A. Willcockson
- , Sean E. Healton
- & Arthur I. Skoultchi
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Letter |
SETD3 is an actin histidine methyltransferase that prevents primary dystocia
SETD3 methylates mammalian actin at His73, and SETD3 deficiency impairs stimulus-induced contraction in primary human uterine smooth muscle cells and leads to maternal dystocia in mice.
- Alex W. Wilkinson
- , Jonathan Diep
- & Or Gozani
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Letter |
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
The methyltransferase METTL3 promotes the leukaemic state in acute myeloid leukaemia (AML) by catalysing the m6A RNA modification through its recruitment on the transcription start sites of AML-associated genes.
- Isaia Barbieri
- , Konstantinos Tzelepis
- & Tony Kouzarides
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Article |
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
Symmetric dimethylation of the human RNA polymerase II C-terminal domain residue R1810 by the protein arginine methyltransferase 5 (PRMT5) directly recruits the protein survival of motor neuron (SMN) and indirectly recruits the helicase senataxin to resolve R-loops and promote transcription termination.
- Dorothy Yanling Zhao
- , Gerald Gish
- & Jack F. Greenblatt
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Letter |
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
SMYD3 is a methyltransferase overexpressed in several human tumours; here methylation of the MAP3K2 kinase by SMYD3 is shown to be critical for Ras-induced tumour development in mouse models and human tumour cells, showing an unexpected role for methylation in a kinase signalling pathway and revealing a candidate therapeutic target.
- Pawel K. Mazur
- , Nicolas Reynoird
- & Or Gozani
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Article |
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
N6-methyladenosine (m6A) is the most prevalent internal modification in messenger RNA; here the human and mouse m6A modification landscape is presented in a transcriptome-wide manner, providing insights into this epigenetic modification.
- Dan Dominissini
- , Sharon Moshitch-Moshkovitz
- & Gideon Rechavi
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Letter |
Clonal selection drives genetic divergence of metastatic medulloblastoma
In a mouse model and in human medulloblastoma patients, the metastases in an individual have similar genomic alterations and DNA methylation patterns, but these patterns are highly divergent from those of the primary tumour, indicating that therapies will need to be tailored to fit the molecular alterations present in the primary tumour and/or the metastases.
- Xiaochong Wu
- , Paul A. Northcott
- & Michael D. Taylor
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Letter |
Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation
A conserved protein from enteropathogenic Escherichia coli, NleE, inhibits innate immune defence against infection by disrupting the NF-κB signalling pathway through methylation of ubiquitin-chain sensing proteins.
- Li Zhang
- , Xiaojun Ding
- & Feng Shao
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Letter |
Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4
The amino-terminal tails of histone proteins are subject to a variety of post-translational modifications; addition or removal of these 'marks' facilitates gene activation or silencing. Here, a mechanism is defined that modulates the activity of the dual-specificity histone demethylase LSD1 during androgen-dependent transcription. Androgen-dependent signalling through protein kinase C beta I leads to phosphorylation of a histone amino acid, which prevents demethylation of an adjacent amino acid by LSD1.
- Eric Metzger
- , Axel Imhof
- & Roland Schüle