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HRG-9 homologues regulate haem trafficking from haem-enriched compartments
HRG-9 (also known as TANGO2) is an evolutionarily conserved haem chaperone that traffics haem from sites of storage or synthesis in eukaryotic cells.
- Fengxiu Sun
- , Zhenzhen Zhao
- & Caiyong Chen
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Article |
Dispatched uses Na+ flux to power release of lipid-modified Hedgehog
Cryo-electron microscopy studies show that dynamic coordination of Na+ in the ion channel of Dispatched homologue 1 and the transmembrane Na+ gradient have key roles in exporting lipid-modified Hedgehog protein signal.
- Qianqian Wang
- , Daniel E. Asarnow
- & Philip A. Beachy
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Article |
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
Structures of the iron transporter ferroportin and the peptide hormone hepcidin suggest how iron homeostasis is tightly regulated.
- Christian B. Billesbølle
- , Caleigh M. Azumaya
- & Aashish Manglik
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Letter |
Synthesis and breakdown of universal metabolic precursors promoted by iron
A chemical reaction network that overlaps with the biological Krebs and glyoxylate cycles arises from pyruvate and glyoxylate in the presence of iron, suggesting how early metabolic pathways might have arisen from CO2.
- Kamila B. Muchowska
- , Sreejith J. Varma
- & Joseph Moran
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Letter |
Crystal structure of the potassium-importing KdpFABC membrane complex
The crystal structure of the bacterial potassium import complex KdpFABC shows how ATP hydrolysis is coupled to potassium transport to maintain cellular homeostasis under low potassium conditions.
- Ching-Shin Huang
- , Bjørn Panyella Pedersen
- & David L. Stokes
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Letter |
Regulation of mitochondrial morphology and function by stearoylation of TFR1
Mitochondria have essential functions within cells, and their dysfunction is linked to various disorders; here, the fatty acid stearic acid (C18:0), which is a dietary component, and the transferrin receptor (TFR1) are shown to regulate mitochondrial function.
- Deniz Senyilmaz
- , Sam Virtue
- & Aurelio A. Teleman
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Letter |
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
Through a quantitative proteomics analysis, a cohort of proteins is identified that associate with autophagosomes, among them a new cargo receptor called NCOA4 that, in response to iron deprivation, targets ferritin to autophagosomes and thereby releases iron.
- Joseph D. Mancias
- , Xiaoxu Wang
- & Alec C. Kimmelman
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Letter |
Structural insight into magnetochrome-mediated magnetite biomineralization
The magnetosome-associated protein mamP is an iron oxidase that reveals a unique arrangement of a self-plugged PDZ domain fused to two magnetochrome domains, defining a new class of c-type cytochrome exclusively found in magnetotactic bacteria.
- Marina I. Siponen
- , Pierre Legrand
- & David Pignol
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Letter |
Biomimetic assembly and activation of [FeFe]-hydrogenases
Three synthetic mimics of the di-iron centre in [FeFe]-hydrogenases are loaded onto the HydF protein and then transferred to apo-HydA1; full activation of HydA1 was achieved only with the HydF hybrid protein that contained the mimic with an azadithiolate bridge, confirming the presence of this ligand in the active site of native [FeFe]-hydrogenases.
- G. Berggren
- , A. Adamska
- & M. Fontecave
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Letter |
Preservation of organic matter in sediments promoted by iron
About one-fifth of organic carbon in sediments is bound to reactive iron phases, which are metastable over geological timescales and may therefore serve as a sink for the long-term storage of organic carbon.
- Karine Lalonde
- , Alfonso Mucci
- & Yves Gélinas
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Article |
Structural basis for iron piracy by pathogenic Neisseria
Structural analysis reveals the iron scavenging mechanism used by Neisseria species, involving TbpA and TbpB proteins, and sheds light on how human transferrin is specifically targeted.
- Nicholas Noinaj
- , Nicole C. Easley
- & Susan K. Buchanan
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Research Highlights |
Manganese fights deadly toxin
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News & Views |
Magnesium in a signalling role
Magnesium binds to enzymes and nucleic acids and is essential for their activity. It emerges that this ion can also function as a signalling molecule with a crucial role in the immune system. See Article p.471
- Ning Wu
- & André Veillette
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Article |
Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
- Feng-Yen Li
- , Benjamin Chaigne-Delalande
- & Michael J. Lenardo
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Research Highlights |
Chemistry: Dissolving precious metals
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News |
Nickel allergy tracked to a single receptor
Molecular pathway reveals why allergen triggers reaction in humans but not in mice.
- Alla Katsnelson
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Research Highlights |
Chemistry: Iodine improvement
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Letter |
Affinity gradients drive copper to cellular destinations
Copper is an essential trace element for eukaryotes and most prokaryotes, but it has toxic side effects, so the levels of intracellular free copper must be limited. Mass spectrometry has now been used to measure the apparent Cu(I)-binding affinities of a representative set of intracellular copper proteins involved in redox catalysis, in copper trafficking to and within different cellular compartments, and in copper storage. The results provide the thermodynamic basis for the kinetic processes that lead to the distribution of cellular copper.
- Lucia Banci
- , Ivano Bertini
- & Peep Palumaa
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Research Highlights |
Conservation: Heavy metal history
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Research Highlights |
Particle physics: Dazzling dysprosium
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News |
Pollutants plucked from air with copper
Fortuitous catalyst discovery offers a new way to suck carbon dioxide from the atmosphere.
- Katharine Sanderson
A druggable copper-signalling pathway that drives inflammation