Metagenomics is the study of the metagenome—the collective genome of microorganisms from an environmental sample—to provide information on the microbial diversity and ecology of a specific environment. Shotgun metagenomics refers to the approach of shearing DNA extracted from the environmental sample and sequencing the small fragments.

Latest Research and Reviews

News and Comment

  • News |

    This Genome Watch highlights how metagenomics can fill the knowledge gap of the wild avian gut microbiome and enable the early detection of antibiotic-resistant bacteria with implications for public health policy and conservation management.

    • Physilia Ying Shi Chua
    •  & Jacob Agerbo Rasmussen
  • News & Views |

    By providing challenges to the metagenomics community based on complex and realistic metagenome benchmark datasets, CAMI — the community-driven initiative for the Critical Assessment of Metagenome Interpretation — has created a comprehensive assessment of the performance of metagenomics software for common analyses. As part of its second contest, CAMI II, it evaluates ~5,000 submissions from 76 software programs and their different versions.

    Nature Methods 19, 412-413
  • Editorial |

    In recent years, large-scale genomic studies have been performed in attempts to determine how genetic variation in the human host influences the gut microbiome. As microbiome traits are very heterogeneous, new analytical approaches are needed to move this field forward. By using genetic tools, there is a huge opportunity to enrich our understanding of the complex link between humans and our intimately associated microbial species.

  • News & Views |

    Construction of a global catalogue of human gut archaeal genomes and their viruses provides insights into the structure, composition and function of the human gut archaeome.

    • Patricia Geesink
    •  & Thijs J. G. Ettema